“…However, materials derived from these compounds often show many drawbacks, like nonappropriate chemical composition, unnatural spatial organization, release of material particles, and often do not possess the necessary specific requirements for cell growth, proliferation and maintenance of the normal phenotype and function. Since it has been recognized that not only the surface chemistry of the substrate but also its topographic features can affect cell behavior surface engineering and modification have been shown to improve, to a variable extent, the biological performance of these materials [3], [7], [8], [9]. In particular, most popular approaches for surface controlled modification as, for example, photo-and softlithography, self-assembling monolayers, microcontact printing and more others, often require the use of synthetic polymers.…”