Biomaterials and host versus graft response: a short review

Velnar, Tomaž; Bunc, Gorazd; Klobucar, Robert; Gradišnik, Lidija

doi:10.17305/bjbms.2016.525

Cited by 46 publications

(55 citation statements)

References 74 publications

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“…Although some inflammation is beneficial to fibroblast-driven integration, xenografts that experience a heightened immune response and encapsulation are frequently acellular, avascular and unincorporated into tissue. These encapsulated grafts provide little support to the patient [32,67,75,76].…”

Section: Clinical Findingsmentioning

confidence: 99%

Managing female pelvic floor disorders: a medical device review and appraisal

2019

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Pelvic floor disorders (PFDs) will affect most women during their lifetime. Sequelae such as pelvic organ prolapse, stress urinary incontinence, chronic pain and dyspareunia significantly impact overall quality of life. Interventions to manage or eliminate symptoms from PFDs aim to restore support of the pelvic floor. Pessaries have been used to mechanically counteract PFDs for thousands of years, but do not offer a cure. By contrast, surgically implanted grafts or mesh offer patients a more permanent resolution but have been in wide use within the pelvis for less than 30 years. In this perspective review, we provide an overview of the main theories underpinning PFD pathogenesis and the animal models used to investigate it. We highlight the clinical outcomes of mesh and grafts before exploring studies performed to elucidate tissue level effects and bioengineering considerations. Considering recent turmoil surrounding transvaginal mesh, the role of pessaries, an impermanent method, is examined as a means to address patients with PFDs.

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Section: Clinical Findingsmentioning

confidence: 99%

Managing female pelvic floor disorders: a medical device review and appraisal

2019

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“…Surface characteristics of the biomaterial and its composition may affect the course and the extent of the immune reaction. Flat and smooth surfaces generally lead to the formation of fibrosis, whereas implants with a rough surface, such as vascular prostheses, become covered by a layer of macrophages and giant cells with variable amounts of granulation tissue which can persist around the implant and potentially isolate it from the local tissue .…”

Section: Synthetic and Natural Scaffoldsmentioning

confidence: 99%

“…Subsequently, macrophages act as the main regulatory cells, activating keratinocytes, fibroblasts, and endothelial cells . Lymphocytes are the last cells recruited, arriving in the late inflammatory period 72 h after the onset of the foreign body reaction .…”

Section: Synthetic and Natural Scaffoldsmentioning

confidence: 99%

Regenerative immunology: the immunological reaction to biomaterials

et al. 2017

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Regenerative medicine promises to meet two of the most urgent needs of modern organ transplantation, namely immunosuppression-free transplantation and an inexhaustible source of organs. Ideally, bioengineered organs would be manufactured from a patient's own biomaterials-both cells and the supporting scaffolding materials in which cells would be embedded and allowed to mature to eventually regenerate the organ in question. While some groups are focusing on the feasibility of this approach, few are focusing on the immunogenicity of the scaffolds that are being developed for organ bioengineering purposes. This review will succinctly discuss progress in the understanding of immunological characteristics and behavior of different scaffolds currently under development, with emphasis on the extracellular matrix scaffolds obtained decellularized animal or human organs which seem to provide the ideal template for bioengineering purposes.

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“…However, implantation of biomaterials is followed by blood–material interaction, which leads to protein adsorption that can initiate an inflammatory cascade comprising injury, followed by acute and chronic inflammation, formation of granulation tissue, foreign body response, and eventually fibrous encapsulation. This represents in the majority of cases an undesired event and is largely influenced by the characteristics of the implanted biomaterials, such as surface properties and compliance and shape (Vasconcelos, Águas, Barbosa, Pelegrín, & Barbosa, ; Velnar, Bunc, Klobucar, & Gradisnik, ). Macrophages play a significant role in the inflammation process and are considered as key effector and dominant cells secreting pro‐inflammatory cytokines such as IL‐1β and tumour necrosis factor‐α (TNFα), chemokines and growth factors, such as monocyte chemoattracting protein 1 (MCP‐1), transforming growth factor‐β, and platelet‐derived growth factor (Oishi & Manabe, ; Wynn & Vannella, ).…”

Section: Introductionmentioning

confidence: 99%

Study on the potential mechanism of anti‐inflammatory activity of covalently immobilized hyaluronan and heparin

Al-Khoury

Hautmann

Erdmann

et al. 2020

J Biomedical Materials Res

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Inflammation and subsequent fibrotic encapsulation that occur after implantation of biomaterials are issues that fostered efforts in designing novel biocompatible materials to modulate the immune response. In this study, glycosaminoglycans (GAG) like hyaluronic acid (HA) and heparin (Hep) that possess anti‐inflammatory activity were covalently bound to NH2‐modified surfaces using EDC/NHS cross‐linking chemistry. Immobilization and physical surface properties were characterized by atomic forces microscopy, water contact angle studies and streaming potential measurements demonstrating the presence of GAG on the surfaces that became more hydrophilic and negatively charged compared to NH2‐modified. THP‐1 derived macrophages were used here to study the mechanism of action of GAG to affect the inflammatory responses illuminated by studying macrophage adhesion, the formation of multinucleated giant cells (MNGCs) and IL‐1β release that were reduced on GAG‐modified surfaces. Detailed investigation of the signal transduction processes related to macrophage activation was performed by immunofluorescence staining of NF‐κB (p65 subunit) together with immunoblotting. We studied also association and translocation of FITC‐labeled GAG. The results show a significant decrease in NF‐κB level as well as the ability of macrophages to associate with and take up HA and Hep. These results illustrate that the anti‐inflammatory activity of GAG is not only related to making surfaces more hydrophilic, but also their active involvement in signal transduction processes related to inflammatory reactions, which may pave the way to design new anti‐inflammatory surface coatings for implantable biomedical devices.

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Biomaterials and host versus graft response: a short review

Cited by 46 publications

References 74 publications

Managing female pelvic floor disorders: a medical device review and appraisal

Managing female pelvic floor disorders: a medical device review and appraisal

Regenerative immunology: the immunological reaction to biomaterials

Study on the potential mechanism of anti‐inflammatory activity of covalently immobilized hyaluronan and heparin

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