Biomaterials

Yoru, A. Binnaz Hazar; Cem, B.

doi:10.5772/48057

Cited by 5 publications

(3 citation statements)

References 62 publications

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“…Metals also have unloaded and functional instrument applications, including clips, heart valves, pacemakers, craniofacial plates, cages for pumps, balloon catheters, conducting wires, prosthetics, medical devices, and equipment. 68–70…”

Section: Classification Of Biomaterialsmentioning

confidence: 99%

A review on β-Ti alloys for biomedical applications: The influence of alloy composition and thermomechanical processing on mechanical properties, phase composition, and microstructure

Kanapaakala

Sathesh

2022

Proceedings of the Institution of Mechanical Engineers, Part L:

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Titanium and its alloys are potential materials for orthopedic implant applications due to their appropriate biological and mechanical behavior. As biocompatibility and biomechanical compatibilities are essential parameters for determining a biomedical implant's performance and service life, this research review article discussed the novel Ti alloys with nontoxic and biocompatible alloying elements with an elastic modulus similar to the bone. Among Ti alloys, β-Ti alloys are appropriate for load-bearing implant applications due to lower elastic modulus and nontoxic elements, including Ti, Ta, Nb, Zr, Sn, and Mo. Even though the β-Ti alloys possess a lesser elastic modulus compared to other metallic biomaterials, two issues associated with β-Ti alloys that result in implant failure are that they still possess a higher elastic modulus than human bone and they have insufficient strength. Alloy composition and thermomechanical processing characteristics play a vital role in altering the mechanical properties and microstructure of β-Ti alloys. Hence, this review article emphasizes the alloying and thermomechanical processing effects on the mechanical properties and microstructure of β-Ti alloys.

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Section: Classification Of Biomaterialsmentioning

confidence: 99%

A review on β-Ti alloys for biomedical applications: The influence of alloy composition and thermomechanical processing on mechanical properties, phase composition, and microstructure

Kanapaakala

Sathesh

2022

Proceedings of the Institution of Mechanical Engineers, Part L:

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“…Biomaterials have a strong reputation in the eld of tissue engineering, clinical devices, drug delivery systems, medical implants, biosensors, cosmetics and food industries. 4,5 Hence, the total market value of biomaterials-based industries are predicted to exceed $88.4 billion by 2017 from a current value of $58.1 billion. Further, every year the USA spends 7-8% of total global healthcare outgoings exclusively on biomaterial related usage alone.…”

Section: Introductionmentioning

confidence: 99%

“…In order to avoid that complication, natural materials are widely coupled with articial synthetic substances which falls under the third category. 5 The longevity of an implant inside the human body is dependent on its ability to avoid creating any adverse reactions or damaging the surrounding environment which chiey banks on the biocompatibility of materials used. But the biocompatibility of a material is greatly inuenced by its physical, chemical, mechanical and biological characteristics.…”

Section: Introductionmentioning

confidence: 99%

Prospects of common biomolecules as coating substances for polymeric biomaterials

et al. 2015

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Biocompatibility of polymer-based biomaterials and medical devices – regulations,in vitroscreening and risk-management

et al. 2018

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Biomaterials play an increasing role in modern health care systems. Biocompatibility poses a significant challenge for manufacturers of medical devices and contemporary intelligent drug delivery technologies from materials development to market approval. Despite a highly regulated environment, biocompatibility evaluation of biomaterials for medical devices is a complex task related to various factors that include mainly chemical nature and physical properties of the material, the contact tissue and duration of contact. Although international standards, such as ISO 10993-1, are generally employed to prove regulatory compliance needed for market clearance or for initiating clinical investigations, they may not offer sufficient guidance, or risk-management perspective when it comes to choosing materials or appropriate in vitro biocompatibility screening methods when developing medical devices. The global normative approach towards the biocompatibility evaluation of medical devices is presented in this review, with a focus on in vitro studies. Indeed, a risk-management approach towards the judicial choice of in vitro tests throughout the development and production of medical devices and drug delivery systems will facilitate rapid regulatory approval, avoid unnecessary animal studies, and ultimately reduce risks for patients. A detailed overview towards the construction of a comprehensive biological evaluation plan is described herein, with a focus on polymer-based materials used in medical applications. Polymeric materials offer a broad spectrum of applications in the manufacturing of medical devices. They are extensively employed within both conventional and innovative drug delivery systems with superior attributes supporting robust, extended use capacity, capable of meeting specific requirement such as adhesion, drug release, and more. Various methods of biocompatibility assessment are detailed within, with an emphasis on scientific analysis. This review may be of interest to those involved in the design, manufacturing and in vitro testing of medical devices and innovative drug delivery technologies, specifically with respect to a risk-management approach towards the biocompatibility assessment of polymer-based devices.

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Biomaterials

Cited by 5 publications

References 62 publications

A review on β-Ti alloys for biomedical applications: The influence of alloy composition and thermomechanical processing on mechanical properties, phase composition, and microstructure

A review on β-Ti alloys for biomedical applications: The influence of alloy composition and thermomechanical processing on mechanical properties, phase composition, and microstructure

Prospects of common biomolecules as coating substances for polymeric biomaterials

Biocompatibility of polymer-based biomaterials and medical devices – regulations,in vitroscreening and risk-management

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