Biomechanical characterization of engineered tissues and implants for tissue/organ replacement applications

Gasik, Michael

doi:10.1016/b978-0-08-102906-0.00024-6

Cited by 4 publications

(17 citation statements)

References 115 publications

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“…It would also be interesting to carry out a pull-out test or rotational test of the embedded posts, but it was not possible due to the limited sample size and geometry samples availability. Pull-out test data, however, are more rate-dependent, so it would require more samples to extrapolate the results to proper strains or deformation rates having clinical relevance [ 25 ]. Furthermore, soft tissues in the pull-out might undergo much more non-uniform deformation or even tearing so data quality would not be certain.…”

Section: Discussionmentioning

confidence: 99%

“…There is sometimes a confusion in the literature about the definition of the shear strains, and in the authors’ opinion the definition used in experiments should always be reported in sufficient detail. For dynamic shear amplitude here, an additional factor of ½ is due to the average amplitude (max–min angle) around the mean static deformation at that time point [ 21 , 25 ]. The stiffness (static and dynamic values in kPa) in this case was calculated as the ratio of respective stress σ i to true or engineering strain ε i [ 26 ].…”

Section: Methodsmentioning

confidence: 99%

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Enhancement of Gingival Tissue Adherence of Zirconia Implant Posts: In Vitro Study

et al. 2021

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Prevention of bacterial inflammation around dental implants (peri-implantitis) is one of the keys to success of the implantation and can be achieved by securing the gingival tissue-abutment interface preventing penetration of bacteria. Modern dental practice has adopted zirconia abutments in place of titanium, but the adhesion of gingival tissue to zirconia is inferior to titanium. The aim of this study was to assess and improve the adhesion of mucosal tissues to zirconia posts using sol-gel derived TiO2 coating following dynamic mechanical testing. The posts were cultivated with porcine bone-gingival tissue specimens in vitro for 7 and 14 days and then subjected to dynamic mechanical analysis simulating physiological loading at 1 Hz up to 50 μm amplitude. In parallel in silico analysis of stresses and strains have been made simulating “the worst case” when the fixture fails in osseointegration while the abutment still holds. Results show treatment of zirconia can lead to double interface stiffness (static shear stiffness values from 5–10 to 17–23 kPa and dynamic from 20–50 to 60–125 kPa), invariant viscostiffness (from 5–35 to 45–90 kPa·sα) and material memory values (increased from 0.06–0.10 to 0.17–0.25), which is beneficial in preventing bacterial contamination in dental implants. This suggests TiO2-coated zirconia abutments may have a significant clinical benefit for prevention of the bacterial contamination.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Enhancement of Gingival Tissue Adherence of Zirconia Implant Posts: In Vitro Study

et al. 2021

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“…It is known that convolution integrals do not in general have a closed analytical form, however, they can be obtained as such for the simple loading (stimulation) patterns, for example, creep, linear ramp, or harmonic case [ 25 ]. For the latter, authors [ 10 , 25 , 26 ] have previously shown that the dynamic stress/strain ratio (“dynamic stiffness”) can be expressed as:

where σ dyn is the applied dynamic stress amplitude, ω —Circular frequency, C ω0 = E 0 × (τ 0 ×ω) α is the viscostiffness (quasi-property in units of kPa·s α ) [ 25 ], α —Dynamic material memory parameter, E 0 —Intrinsic dynamic elasticity, τ 0 —Intrinsic characteristic time. This Equation (2) time-convolutes the specimen loading history at every frequency without Fourier transform or assumptions of a material model (Maxwell, Burger, standard linear solid, Prony series, etc.…”

Section: Resultsmentioning

confidence: 99%

“…GAIN scaffolds biomechanical characterization was performed as referred to § 10 of Annex I of EU Medical Devices Regulations (2017/745) to align the data with the physiologically important limits (frequency 1 Hz, deformation amplitudes for the typical cells size range) [ 8 , 10 , 24 ]. Specimens geometry was controlled with ±1 µm precision using non-contact laser micrometer (Metralight, Inc., Burlingame, CA, USA).…”

Section: Methodsmentioning

confidence: 99%

“…Whereas biomechanical and mechanobiological interactions of cells and bacteria with various biomaterials and their surfaces has been extensively studied [ 10 , 11 , 12 , 13 ], much less is known about the interactions between biomaterials and viruses. Viruses have lesser dimensions as compared to cells or bacteria, and they are lacking features, which are typical for the cell membrane.…”

Section: Introductionmentioning

confidence: 99%

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Biomechanical Features of Graphene-Augmented Inorganic Nanofibrous Scaffolds and Their Physical Interaction with Viruses

et al. 2020

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Nanofibrous substrates and scaffolds are widely being studied as matrices for 3D cell cultures, and disease models as well as for analytics and diagnostic purposes. These scaffolds usually comprise randomly oriented fibers. Much less common are nanofibrous scaffolds made of stiff inorganic materials such as alumina. Well-aligned matrices are a promising tool for evaluation of behavior of biological objects affected by micro/nano-topologies as well as anisotropy. In this work, for the first time, we report a joint analysis of biomechanical properties of new ultra-anisotropic, self-aligned ceramic nanofibers augmented with two modifications of graphene shells (GAIN scaffolds) and their interaction of three different viral types (influenza virus A, picornavirus (human parechovirus) and potato virus). It was discovered that nano-topology and structure of the graphene layers have a significant implication on mechanical properties of GAIN scaffolds resulting in non-linear behavior. It was demonstrated that the viral adhesion to GAIN scaffolds is likely to be guided by physical cues in dependence on mutual steric factors, as the scaffolds lack common cell membrane proteins and receptors which viruses usually deploy for transfection. The study may have implications for selective viral adsorption, infected cells analysis, and potentially opening new tools for anti-viral drugs development.

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Mechanical stimulation devices for mechanobiology studies: a market, literature, and patents review

et al. 2023

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Significant advancements in various research and technological fields have contributed to remarkable findings on the physiological dynamics of the human body. To more closely mimic the complex physiological environment, research has moved from two-dimensional (2D) culture systems to more sophisticated three-dimensional (3D) dynamic cultures. Unlike bioreactors or microfluidic-based culture models, cells are typically seeded on polymeric substrates or incorporated into 3D constructs which are mechanically stimulated to investigate cell response to mechanical stresses, such as tensile or compressive. This review focuses on the working principles of mechanical stimulation devices currently available on the market or custom-built by research groups or protected by patents and highlights the main features still open to improvement. These are the features which could be focused on to perform, in the future, more reliable and accurate mechanobiology studies. Graphic abstract

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Biomechanical characterization of engineered tissues and implants for tissue/organ replacement applications

Cited by 4 publications

References 115 publications

Enhancement of Gingival Tissue Adherence of Zirconia Implant Posts: In Vitro Study

Enhancement of Gingival Tissue Adherence of Zirconia Implant Posts: In Vitro Study

Biomechanical Features of Graphene-Augmented Inorganic Nanofibrous Scaffolds and Their Physical Interaction with Viruses

Mechanical stimulation devices for mechanobiology studies: a market, literature, and patents review

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