Background: Multiple anatomical features of the femoral condyles and tibial plateau have been shown to influence knee biomechanics and risk of anterior cruciate ligament (ACL) injury. However, it remains unclear how these anatomical factors affect the midterm outcomes of ACL reconstruction. Hypothesis: Decreased femoral notch width, increased posterior and coronal slopes, and decreased concavity of the tibial plateau are associated with inferior clinical, patient-reported and osteoarthritis-related outcomes 7 years after ACL reconstruction. Study Design: Cohort Study (level 3). Methods: Prospectively collected data from 44 patients who did not have a subsequent graft or contralateral ACL failure within 7 years after unilateral ACL reconstruction were reviewed (23.7±9.2 years; 64% women). Notch width (after notchplasty), posterior slopes of the medial and lateral tibial plateau, maximum depth of the medial tibial plateau, and coronal tibial slope were measured from magnetic resonance images. Anatomical predictors of side-to-side differences in AP knee laxity (KT-1000 Knee Arthrometer), KOOS scores, medial joint space width and side-toside differences in OARSI score, measured at 7 years, were identified using linear regression (bivariate) and stepwise regression (multivariate). Results: Increased posterior slope of the lateral tibial plateau was associated with increased sideto-side difference in knee laxity (bivariate model only), increased side-to-side difference in OARSI score, and decreased KOOS sub-scores (R 2 >.10, p<.05). Increased posterior slope of the medial tibial plateau was associated with a higher side-to-side difference in OARSI score (bivariate model only) and lower KOOS sub-scores (R 2 >.11, p<.03). Increased coronal tibial slope was associated