Biomechanical factors associated with the development of tibiofemoral knee osteoarthritis: protocol for a systematic review and meta-analysis

Abstract

IntroductionAltered biomechanics, increased joint loading and tissue damage, might be related in a vicious cycle within the development of knee osteoarthritis (KOA). We have defined biomechanical factors as joint-related factors that interact with the forces, moments and kinematics in and around a synovial joint. Although a number of studies and systematic reviews have been performed to assess the association of various factors with the development of KOA, a comprehensive overview focusing on biomechanical factors that are associated with the development of KOA is not available. The aim of this review is (1) to identify biomechanical factors that are associated with (the development of) KOA and (2) to identify the impact of other relevant risk factors on this association.Methods and analysisCohort, cross-sectional and case–control studies investigating the association of a biomechanical factor with (the development of) KOA will be included. MEDLINE, EMBASE, CINAHL and SPORTDiscus will be searched from their inception until August 2015. 2 reviewers will independently screen articles obtained by the search for eligibility, extract data and score risk of bias. Quality of evidence will be evaluated. Meta-analysis using random effects model will be applied in each of the biomechanical factors, if possible.Ethics and disseminationThis systematic review and meta-analysis does not require ethical approval. The results of this systematic review and meta-analysis will be disseminated through publications in peer-reviewed journals and presentations at (inter)national conferences.Trial registration numberCRD42015025092.

Association of malalignment, muscular dysfunction, proprioception, laxity and abnormal joint loading with tibiofemoral knee osteoarthritis - a systematic review and meta-analysis

“…The protocol for this systematic review and meta-analysis [ 14 ] has been published previously and has been registered with the International Prospective Register of Systematic Reviews (PROSPERO ID: CRD42015025092). This systematic review and meta-analysis follows the Cochrane Collaboration guideline for preparing systematic review and meta-analysis and are reported according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guideline [ 15 ].…”

“…Searches used subject headings (MeSH) and text words related to osteoarthritis, biomechanical factors and study types. The complete search strategy can be found in the study protocol [ 14 ].…”

“…compared one knee with, and one knee without osteoarthritis within the same participant); 6) both knees are assessed in patients with bilateral knee OA. A detailed description of the eligibility criteria can be found in the study protocol [ 14 ].…”

“…Risk of bias was scored independently by two reviewers (JT, ADI) using the Quality In Prognostic Studies (QUIPS) tool [ 16 ] as described in the protocol [ 14 ]. Six areas of potential study biases were assessed: study participation, study attrition, prognostic factor measurement, study confounding, outcome measurement, and statistical analysis and reporting.…”

Association between GDF5 +104T/C polymorphism and knee osteoarthritis in Caucasian and Asian populations: a meta-analysis based on case-control studies

“…Osteoarthritis (OA) is a chronic and progressive condition causing pain and disability worldwide and is regarded as a disease of the entire joint [ 1 , 2 ]. Obesity, age, and joint injury are the major risk factors for OA of the knee [ 3 , 4 ]. In addition, heritability studies have shown that genetic components account for approximately half of the risk for development of OA of the knee [ 5 – 7 ].…”