2022
DOI: 10.7150/thno.74571
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Biomechanical microenvironment in peripheral nerve regeneration: from pathophysiological understanding to tissue engineering development

Abstract: Peripheral nerve injury (PNI) caused by trauma, chronic disease and other factors may lead to partial or complete loss of sensory, motor and autonomic functions, as well as neuropathic pain. Biological activities are always accompanied by mechanical stimulation, and biomechanical microenvironmental homeostasis plays a complicated role in tissue repair and regeneration. Recent studies have focused on the effects of biomechanical microenvironment on peripheral nervous system development and function maintenance,… Show more

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Cited by 39 publications
(15 citation statements)
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“…[25] In the context of successful CNS regeneration, transplanted OECs must cross the OEC-astrocyte boundary and form an aligned structure that guides regenerating axons to their target. Over the past few decades, several strategies, such as the use of aligned-structure biomaterials, [4a] chemotactic induction, [26] and physical cues [27] have been proposed to enhance local cell orientation. Despite these efforts, orienting cell migration and alignment in the CNS remains a significant challenge due to the formation of OEC-astrocyte borders.…”
Section: Discussionmentioning
confidence: 99%
“…[25] In the context of successful CNS regeneration, transplanted OECs must cross the OEC-astrocyte boundary and form an aligned structure that guides regenerating axons to their target. Over the past few decades, several strategies, such as the use of aligned-structure biomaterials, [4a] chemotactic induction, [26] and physical cues [27] have been proposed to enhance local cell orientation. Despite these efforts, orienting cell migration and alignment in the CNS remains a significant challenge due to the formation of OEC-astrocyte borders.…”
Section: Discussionmentioning
confidence: 99%
“…[3][4][5] The dynamic biochemical microenvironment homeostasis is balanced by the extracellular matrix network, blood vessels, and lymphatic vessels in connective tissues from the macroscopic level, as well as cell adhesion molecules, cytokines, chemokines secreted by Schwann cells (SCs), fibroblast cells, endothelial cells, and various immune cells at the microscopic level. [6][7][8][9] The anatomical structure of the peripheral nerve consists of bundles of longitudinal axons with or without myelinated glial cells (known as SCs) that are surrounded by three-layer membrane structures, namely, the endoneurium, perineurium, and epineurium, from the inside to the outside, respectively (Fig. 1(A)).…”
Section: Introductionmentioning
confidence: 99%
“…Tissue-engineered nerve conduits (TENCs) can provide more sophisticated versions of scaffolding for nerve grafts that can enhance the process of regeneration by reducing neuromas, scars, and lateral germination, without any donor site morbidity and limitations in the availability of grafts. [15][16][17][18] They facilitate regeneration through alignment of the distal and proximal ends of the injured nerve and protect it from overgrowth of the surrounding fibrous tissue. For instance, cell sheet-based pre-vascularized hollow grafts can promote rapid vascularization of nerve conduits providing efficient recovery of motor functions compared to autografts.…”
Section: Introductionmentioning
confidence: 99%