Biomechanical Properties of the Cranial Dura Mater with Puncture Defects : An In Vitro Study

Aydın, Hasan Emre; Kızmazoğlu, Ceren; Kaya, İsmail; Hüsemoğlu, R. Buğra; Sozer, Gulden; Havıtçıoğlu, Hasan; Arslantaş, Ali

doi:10.3340/jkns.2018.0130

Cited by 16 publications

(17 citation statements)

References 25 publications

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“…The cranial meninges are the falx of the brain, the tentorium of the cerebellum, the falx of the cerebellum and the pituitary tent [7][8]. The dura mater of the skull, which covers the arachnoid layer and has an average thickness of one millimeter, has anisotropic viscoelastic properties, with a capacity to withstand mechanical forces of about 9-10 Pa (MPa which in this case is equivalent to 1 kilo per millimeter of square meter) [40]. The dura mater is defined as pachymeninge, while the arachnoid and the pial layer fall within the classification of leptomenynx.…”

Section: The Mobility Of the Cranial And Spinal Meningeal Membranesmentioning

confidence: 99%

The Cranial Bowl in the New Millennium and Sutherland's Legacy for Osteopathic Medicine: Part 1

Bordoni

Walkowski²,

Ducoux³

et al. 2020

Cureus

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A theoretical model that does not evolve with new information deriving from scientific research, by changing the assumptions from which it was born, becomes a philosophy; the scientist becomes a scholarch. Cranial manual osteopathic medicine is very controversial, although it is commonly practiced, from the clinician to the nonmedical health worker. The article, divided into two parts, reviews the assumptions with which the cranial model was created, highlighting the scientific innovations and new anatomical-physiological reflections. In the first part we will review the synthesis and movement of cerebrospinal fluid (CSF), the movement of the central and peripheral nervous system; we will highlight the mechanical characteristics of the meninges. The aim of the article is to highlight the need to renew the existing cranial model.

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Section: The Mobility Of the Cranial And Spinal Meningeal Membranesmentioning

confidence: 99%

The Cranial Bowl in the New Millennium and Sutherland's Legacy for Osteopathic Medicine: Part 1

Bordoni

Walkowski²,

Ducoux³

et al. 2020

Cureus

View full text Add to dashboard Cite

show abstract

“…These were published between 1970 and 2020. Of these, 13 studies were conducted on cranial (Aydin et al 2019 ; Galford and McElhaney 1970 ; Kizmazoglu et al 2019 ; McGarvey et al 1984 ; Melvin et al 1970 ; Sacks et al 1998 ; van Noort et al 1981 ; Wolfinbarger et al 1994 ; Yamada et al 1997 ; Zwirner et al 2019a , b , c , 2020 ) and 4 on spinal dura mater (Patin et al 1993 ; Runza et al 1999 ; Tencer et al 1985 ; Zarzur 1996 ), respectively. A summary of the retrieved information from the searched studies is given in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

“…The sample characteristics varied between studies. The number of mechanically investigated samples ranged from 7 (Aydin et al 2019 ) to 124 (Zwirner et al 2020 ). Cadaver numbers ranged from 5 (Sacks et al 1998 ) to 75 (Zwirner et al 2020 ).…”

Section: Resultsmentioning

confidence: 99%

“…Several factors give rise to the lack of information available, including but not limited to the availability of fresh cadaveric tissues, the expertise of research teams in anatomy and engineering or financial challenges to buy required testing equipment. As a prime example, the biomechanical characterization of the dura mater was investigated further throughout the past three years (Aydin et al 2019 ; Kizmazoglu et al 2019 ; Zwirner et al 2019a , b , c , 2020 ). The biomechanical properties of cranial dura mater are paramount to select and fabricate appropriate artificial substitutes for duraplasty, such as the Gore-Tex Expanded Cardiovascular Patch (W.L.…”

Section: Introductionmentioning

confidence: 99%

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Systematic review and meta-analysis of the biomechanical properties of the human dura mater applicable in computational human head models

Pearcy

Tomlinson

Niestrawska

et al. 2022

Biomech Model Mechanobiol

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Accurate biomechanical properties of the human dura mater are required for computational models and to fabricate artificial substitutes for transplantation and surgical training purposes. Here, a systematic literature review was performed to summarize the biomechanical properties of the human dura mater that are reported in the literature. Furthermore, anthropometric data, information regarding the mechanically tested samples, and specifications with respect to the used mechanical testing setup were extracted. A meta-analysis was performed to obtain the pooled mean estimate for the elastic modulus, ultimate tensile strength, and strain at maximum force. A total of 17 studies were deemed eligible, which focused on human cranial and spinal dura mater in 13 and 4 cases, respectively. Pooled mean estimates for the elastic modulus (n = 448), the ultimate tensile strength (n = 448), and the strain at maximum force (n = 431) of 68.1 MPa, 7.3 MPa and 14.4% were observed for native cranial dura mater. Gaps in the literature related to the extracted data were identified and future directions for mechanical characterizations of human dura mater were formulated. The main conclusion is that the most commonly used elastic modulus value of 31.5 MPa for the simulation of the human cranial dura mater in computational head models is likely an underestimation and an oversimplification given the morphological diversity of the tissue in different brain regions. Based on the here provided meta-analysis, a stiffer linear elastic modulus of 68 MPa was observed instead. However, further experimental data are essential to confirm its validity.

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“…Due to the small size and non-uniform symmetry of the lungs samples, it is challenging to estimate the exact cross-sectional area to calculate elastic modulus. Therefore, in this study, only the stiffness measurements are considered for subsequent analysis and comparison via a custom-built-up stretcher device (De Kegel et al, 2018;Aydın et al, 2019;Sezgin et al, 2019). For the first time in the literature, showed that lung stiffness increased in the SOD1 G93A mutated male rats compared to the SOD1 WT rats even at the very early stages of life, indicating impaired tissue function (Figure 2).…”

Section: Discussionmentioning

confidence: 99%

Impact of the Amyotrophic Lateral Sclerosis Disease on the Biomechanical Properties and Oxidative Stress Metabolism of the Lung Tissue Correlated With the Human Mutant SOD1G93A Protein Accumulation

Aydemir

Malik

Kulaç

et al. 2022

Front. Bioeng. Biotechnol.

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Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease, and ALS incidence is increasing worldwide. Patients with ALS have respiratory failure at the disease’s end stages, leading to death; thus, the lung is one of the most affected organs during disease progression. Tissue stiffness increases in various lung diseases because of impaired extracellular matrix (ECM) homeostasis leading to tissue damage and dysfunction at the end. According to the literature, oxidative stress is the major contributor to ECM dysregulation, and mutant protein accumulation in ALS have been reported as causative to tissue damage and oxidative stress. In this study, we used SOD1G93A and SOD1WT rats and measured lung stiffness of rats by using a custom-built stretcher, where H&E staining is used to evaluate histopathological changes in the lung tissue. Oxidative stress status of lung tissues was assessed by measuring glucose 6-phosphate dehydrogenase (G6PD), 6-phosphogluconate dehydrogenase (6-PGD), glutathione reductase (GR), glutathione s-transferase (GST), catalase (CAT), and superoxide dismutase 1 (SOD1) levels. Western blot experiments were performed to evaluate the accumulation of the SOD1G93A mutated protein. As a result, increased lung stiffness, decreased antioxidant status, elevated levels of oxidative stress, impaired mineral and trace element homeostasis, and mutated SOD1G93A protein accumulation have been found in the mutated rats even at the earlier stages, which can be possible causative of increased lung stiffness and tissue damage in ALS. Since lung damage has altered at the very early stages, possible therapeutic approaches can be used to treat ALS or improve the life quality of patients with ALS.

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Biomechanical Properties of the Cranial Dura Mater with Puncture Defects : An In Vitro Study

Cited by 16 publications

References 25 publications

The Cranial Bowl in the New Millennium and Sutherland's Legacy for Osteopathic Medicine: Part 1

The Cranial Bowl in the New Millennium and Sutherland's Legacy for Osteopathic Medicine: Part 1

Systematic review and meta-analysis of the biomechanical properties of the human dura mater applicable in computational human head models

Impact of the Amyotrophic Lateral Sclerosis Disease on the Biomechanical Properties and Oxidative Stress Metabolism of the Lung Tissue Correlated With the Human Mutant SOD1G93A Protein Accumulation

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