Biomechanics in ascending aortic aneurysms correlate with tissue composition and strength

Dobson, Gary; Fedak, Paul W.M.; Nightingale, Miriam; Gregory, Alexander J.; Beddoes, Richard; Nickel, Alicia; Sattari, Samaneh; Sigaeva, Taisiya; Bromley, Amy; Appoo, Jehangir J.; Martino, Elena S. Di

doi:10.1016/j.xjon.2021.12.001

Cited by 18 publications

(18 citation statements)

References 28 publications

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“…LTM and TZ O were measured assuming that physiological loading of the ascending aorta ranges from zero stress to the early phase in the transition zone (Figure 1, D , in Nightingale and colleagues 1 ). However, the aorta is always under non-zero stress due to blood pressure and its ring configuration.…”

Section: Which Parameters Are More Physiologic?mentioning

confidence: 99%

“… 2 , 4 The current study showed that, across several domains, correlations with microstructural components were stronger with energy loss than with either LTM and TZ O . 1 …”

Section: Energy Loss Correlates Well With Underlying Microstructurementioning

confidence: 99%

“…We read with interest the article by Nightingale and colleagues, 1 who introduced 2 biomechanical parameters, low strain tangential modulus (LTM) and onset stress of the transition zone (TZ O ), for assessing ascending aortic aneurysms. It is critically important that parameters measuring aortic biomechanics (1) can be measured in the physiologic range and therefore translate clinically, (2) correlate with failure properties as these are the true metrics of interest, and (3) correlate with underlying aortic wall microstructure.…”

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confidence: 99%

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Searching for a physiologically meaningful parameter for aortic biomechanics—is energy loss the way?

2022

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Section: Which Parameters Are More Physiologic?mentioning

confidence: 99%

“… 2 , 4 The current study showed that, across several domains, correlations with microstructural components were stronger with energy loss than with either LTM and TZ O . 1 …”

Section: Energy Loss Correlates Well With Underlying Microstructurementioning

confidence: 99%

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Searching for a physiologically meaningful parameter for aortic biomechanics—is energy loss the way?

2022

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“…Cauchy stress and stretch were determined from the average local deformation gradient found via optical dot tracking, the global force readings in each direction, and the initial specimen dimensions, with the assumption of tissue homogeneity and incompressibility (Forneris et al, 2021;Nightingale et al, 2021). If high shear was present, the deformation gradient was calculated excluding the dot corresponding to the region of high shear.…”

Section: Biaxial Tensile Testingmentioning

confidence: 99%

Medial Collagen Type and Quantity Influence Mechanical Properties of Aneurysm Wall in Bicuspid Aortic Valve Patients

Neave

Tahir²,

Nightingale³

et al. 2022

Front. Mech. Eng.

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Collagen has an essential role in aortic biomechanics, and collagen remodeling has been associated with the development and progression of aortic aneurysm. However, the exact mechanisms behind collagen remodeling and the biomechanical implications are not well understood. This study presents an investigation of the relationship between collagen remodeling in the aortic wall and biomechanics, by means of collagen assays, smooth muscle cell gene expression, and mechanical testing on human aortic specimens collected from patients with bicuspid aortic valve. Collagen assay analysis was employed to determine collagen-I and total collagen content; quantitative real-time PCR was used to determine amounts COL1A1 and COL3A1 expression in the tissue. These parameters were compared with the local biomechanical properties determined from biaxial and uniaxial tensile testing. Collagen-I content was found to relate to improved mechanical properties, while total collagen content did not exhibit a relationship with biomechanics. COL1A1 and COL3A1 expression were found to relate to the collagen-I content of the tissue, but not the total collagen content or biomechanical performance. Relationships between variables appeared to be dependent on the collagen content in specific layers of the aortic wall. The effect of age is also noted, as total collagen content and biomechanics were found to have significant associations with increasing age, while collagen-I content and collagen gene expression did not exhibit any correlation. Varying relationships were observed when looking at younger versus older patients. Findings highlight the importance of type and location in determining the influence of collagen on aortic biomechanics, as well as the role of gene expression in the onset and progression of collagen remodeling in aortic aneurysm.

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“…Stemming from the Commentary by Tang and colleagues 1 on our article, 2 we were excited to be invited to elaborate more on the biaxial ex vivo biomechanical parameters for assessing ascending aortic aneurysms. Particularly, Tang and colleagues 2 raise an excellent point regarding the limitations of ex vivo testing.…”

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confidence: 99%

Reply from authors: Toward physiologically meaningful biomechanical parameters from ex vivo biaxial testing

2022

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Biomechanics in ascending aortic aneurysms correlate with tissue composition and strength

Cited by 18 publications

References 28 publications

Searching for a physiologically meaningful parameter for aortic biomechanics—is energy loss the way?

Searching for a physiologically meaningful parameter for aortic biomechanics—is energy loss the way?

Medial Collagen Type and Quantity Influence Mechanical Properties of Aneurysm Wall in Bicuspid Aortic Valve Patients

Reply from authors: Toward physiologically meaningful biomechanical parameters from ex vivo biaxial testing

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