Biomedical and antifungal application of Cu (II) soaps and its urea complexes derived from various oils

Sharma, Arun Kumar; Saxena, Meenakshi; Sharma, Rishabh

doi:10.15406/oajtmr.2018.02.00033

Cited by 8 publications

(7 citation statements)

References 6 publications

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“…This confirms that the experimental data are well satisfactory. The descriptive statistics results of CL rt S and Cl rt T showed in Tables 6-8 confirm satisfactory results in triplet for all the fungi studied earlier in our laboratory and other studies conducted by scientists [30]. The findings are similar to our studies on different systems [31].…”

Section: Fungicidal Activitiessupporting

confidence: 90%

Fungicidal Activities and Characterization of Novel Biodegradable Cu (II) Surfactants Derived from Lauric Acid

Sharma¹,

Saxena²,

Sharma³

2018

CHEM

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Introduction: Colloidal systems are extremely widespread in nature and are of great practical importance in our daily life. Surfactants are very important in modern engineering and pharmaceutical soap and the complexes of soaps with different ligands are used in almost all sectors of national economy due to the formation of micelles in solutions and high surface activity i.e. the ability of their molecules to form surface adsorption layers. For this purpose, first time we thought about the synthesis of copper surfactants/soaps and their complexation by N/S donor ligands. Methods and Materials: In this paper, we report the synthesis of copper laurate thiourea by conventional methods and its characterization by elemental analysis, IR, NMR, ESR spectral studies. In order to understand their biological aspects and application of these surfactants/complexes as antifungal agents, astudy has also been conducted in the field of biochemistry. In order to understand their biological aspects with special reference to fungicidal activities, three different fungi namely Aspergillus alternaria, Aspergillus Fumigatus and Aspergillus niger were taken and tested by different concentrations of copper laurate soap and its thiourea complex by P.D.A. (Potato dextrose agar) technique. Conclusion: Biological studies of these compounds will also provide an important account of information about their industrial utilization.

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Section: Fungicidal Activitiessupporting

confidence: 90%

Fungicidal Activities and Characterization of Novel Biodegradable Cu (II) Surfactants Derived from Lauric Acid

Sharma¹,

Saxena²,

Sharma³

2018

CHEM

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“…The plots of ψ/√c v/s √c was characterized by an intersection of two straight lines at a point corresponding to the CMC of the soap Fig. (8). The values of CMC are in close agreement with the values obtained fromη v/s c, η sp v/s c, ϕ v/s c plots.…”

Section: Einstein Equation [33]supporting

confidence: 78%

Surface Active Properties and Micellar Features of Copper Soaps Derived from Various Edible Oils

Sharma¹,

Saxena²,

Sharma³

2018

CHEM

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Introduction: The molar volume, viscosity, specific viscosity, and fluidity of copper surfactant derived from various edible oils in methanol -benzene solvent have been determined at a constant temperature 303 K. Methods / Results: The results were used to calculate (CMC), soap complex-solvent interactions and the effect of chain length of the surfactant molecule on various parameters. The conclusions with regard to soap-soap and soap- methanol -benzene interaction have been discussed in terms of well-known Moulik’s and Jones- Dole equations. The effect of surfactant concentration on viscosity of the solution in solvent mixture has been discussed. Conclusion: The observations suggested that the structure breaking effect by the solute on the solvent molecules is more prominent above CMC as compared to below CMC after the formation of the micelles. The vital information plays an important role in various industrial process as well as biological applications.

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“…All the tests were performed in triplicate the standard deviation has been measured by the conventional measure of repeatability and the average was taken as final reading. The results of ANOVA for the antifungal activities for all sops complexes are shown in Table 4 [27,28].The predicted R 2 are in reasonable agreement and closer to 1.0 [29,30]. This confirms that the experimental data are well satisfactory.…”

Section: Fungicidal Activitiessupporting

confidence: 55%

Antimicrobial Studies and Characterization of Copper Surfactants Derived from Various Oils Treated at High Temperatures by P.D.A. Technique

Bhutra¹,

Sharma²,

Sharma³

2018

PHARMSCI

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Introduction: Biologically potent compounds are one of the most important classes of materials for the upcoming generations. Increasing number of microbial infectious diseases and resistant pathogens create a demand and urgency to develop novel, potent, safe and improved variety of antimicrobial agents. This initiates a task for current chemistry to synthesize compounds that show promising activity as therapeutic agents with lower toxicity. Therefore, a substantial research is needed for their discovery and improvement. Chemistry of present era aims to build a pollution free environment. For the same, it targets to create some alternativeswhich are eco-friendly and nature loving. Present research work is a step towards achieving such alternatives. Method: For this the metallic soaps of copper (derived from common edible oils) were synthesized. The synthesized copper soaps have been confirmed by elemental analysis, UV, and IR spectroscopic technique. The fungicidal activities of copper soaps derived from soyabean, sesame oils have been evaluated by testing against Alternaria alternate and Aspergillus niger by P.D.A. technique. Result: The fungi toxicity results indicate that the strain of fungal species are susceptible towards these soaps and suggests that with the increase in concentration of copper soap it may increase further. The transition metallic soaps showed good antifungal activity because chelation increases the anti-microbial potency.

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Biomedical and antifungal application of Cu (II) soaps and its urea complexes derived from various oils

Cited by 8 publications

References 6 publications

Fungicidal Activities and Characterization of Novel Biodegradable Cu (II) Surfactants Derived from Lauric Acid

Fungicidal Activities and Characterization of Novel Biodegradable Cu (II) Surfactants Derived from Lauric Acid

Surface Active Properties and Micellar Features of Copper Soaps Derived from Various Edible Oils

Antimicrobial Studies and Characterization of Copper Surfactants Derived from Various Oils Treated at High Temperatures by P.D.A. Technique

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