Biomedical Applications of Biomimetic Polymers: The Phosphorylcholine‐Containing Polymers

Lewis, Andrew L.; Lloyd, Andrew W.

doi:10.1002/9781118129906.ch4

Cited by 7 publications

(3 citation statements)

References 223 publications

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“…As shown in Table , many medical devices using the MPC polymer have been approved and clinically used. These have been summarized well in the book chapters . Coronary guide wires developed in the United Kingdom were the first medical devices to be coated with MPC polymers, specifically PMD .…”

Section: Application Of Mpc Polymers In Medical Devicesmentioning

confidence: 99%

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Revolutionary advances in 2‐methacryloyloxyethyl phosphorylcholine polymers as biomaterials

Ishihara

2019

J Biomedical Materials Res

186

167

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In the last 40 years, many strategies to fabricate biocompatible and antithrombogenic polymers have been proposed, especially in Japan. The development of one such polymers composed of 2‐methacryloyloxyethyl phosphorylcholine unit, is described in this review, with specific examples of use in biomedical devices. These polymers are typically incorporated into other materials to effectively prevent unfavorable biological responses and reactions. For example, the polymers suppress protein adsorption and cell adhesion to materials in contact with plasma or whole blood, even in the absence of anticoagulant. These properties are due to the extreme hydrophilicity and electrically neutral nature of the polymers, as well as to the ability of phosphorylcholine to induce bulk‐like behavior in surrounding waters. Accordingly, these polymers have been used worldwide to modify the surfaces and improve the overall biocompatibility of such medical devices as long‐term implantable artificial organs. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 933–943, 2019.

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Section: Application Of Mpc Polymers In Medical Devicesmentioning

confidence: 99%

“…These have been summarized well in the book chapters. [109][110][111] Coronary guide wires developed in the United Kingdom were the first medical devices to be coated with MPC polymers, specifically PMD. 112 The coat significantly suppresses thrombogenesis, which occurs at 48% of uncoated guide wires.…”

Section: Cardiovascular Devicesmentioning

confidence: 99%

Revolutionary advances in 2‐methacryloyloxyethyl phosphorylcholine polymers as biomaterials

Ishihara

2019

J Biomedical Materials Res

186

167

View full text Add to dashboard Cite

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“…In turn, they may serve as excellent biointerfaces between artificial materials and biological systems [23][24][25][26]. Synthetic and purification methods to produce massive amounts of MPC have been established by Ishihara [27,28], taking advantage of this material in a wide range of biomedical applications, such as surface modification of long-term implantable artificial organs [29][30][31][32]. The mixing of two aqueous MPC polymer solutions induced the spontaneous formation of a hydrogel in aqueous medium at room temperature via hydrogen bonding without any chemical treatment [33][34][35][36].…”

Section: Spontaneously Forming Hydrogels Designed With Phospholipid Pmentioning

confidence: 99%