Biomedical Applications of Cyclodextrin Based Polyrotaxanes

Loethen, Scott; Kim, Jong-Mok; Thompson, David H.

doi:10.1080/15583720701455145

Cited by 149 publications

(107 citation statements)

References 156 publications

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“…The structure of polyrotaxanes with an appropriate polymer axle, macrocycle wheels threaded on the axle, and bulky terminal groups capped on the end of the axle to avoid the dethreading of the macrocycle wheels has attracted great interest for several decades [1][2][3][4] (Fig. 1b).…”

Section: Introductionmentioning

confidence: 99%

“…Since the most remarkable synthesis of polyrotaxanes composed of a-CD rings threaded on a poly(ethylene oxide) (PEO) chain and capped with bulky terminal groups ( Fig. 1), overwhelming interest has focused on the study of the supramolecular structure of polyrotaxanes and their biomedical and pharmaceutical applications [1][2][3][7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

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Supramolecular Polymers Based on Cyclodextrins for Drug and Gene Delivery

Zhao

2010

Biofunctionalization of Polymers and Their Applications

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Supramolecular polymers based on cyclodextrins (CDs) have inspired interesting and rapid developments as novel biomaterials in a broad range of drug and gene delivery applications, due to their low cytotoxicity, controllable size, and unique architecture. This review will summarize the potential applications of polyrotaxanes in the field of drug delivery and gene delivery. Generally, cyclodextrin-based biodegradable polypseudorotaxane hydrogels could be used as a promising injectable drug delivery system for sustained and controlled drug release. Temperature-responsive, pH-sensitive, and controllable hydrolyzable polyrotaxane hydrogels have attracted much attention because of their controllable properties, and the self-assembly micelles formed by amphiphilic copolymer threaded with CDs could be used as a carrier for controlled and sustained drug release. Polyrotaxanes with drug or ligand conjugated CDs threaded on a polymer chain with a biodegradable end group could be useful for controlled and multivalent targeted delivery. In the field of gene delivery, cationic polyrotaxanes consisting of multiple OEI-grafted CDs threaded on a block copolymer chain are attractive non-viral gene carries due to the strong DNA-binding ability, low cytotoxicity, and high gene delivery capability. Furthermore, cytocleavable end-caps were introduced in the polyrotaxane systems in order to ensure efficient endosomal escape for intracellular trafficking of DNA. The development of the supramolecular approach using CD-containing polyrotaxanes is expected to provide a new paradigm for biomaterials.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Supramolecular Polymers Based on Cyclodextrins for Drug and Gene Delivery

Zhao

2010

Biofunctionalization of Polymers and Their Applications

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“…The β-CD is the most abundant natural oligomers and corresponds to the association of seven glucose units with cavity, which exhibits a hydrophobic character whereas the exterior is strongly hydrophilic. Their ability to form host-guest complexes has led to the use of CDs in a number of fields [1,2]. CDs have been used in the pharmaceutical industry, as solubilizers, diluents and as tablet ingredients which improve the chemical stability, solubility, bioavailability and pharmacokinetic properties of drugs.…”

Section: Introductionmentioning

confidence: 99%

Salicylanilide /Cyclodextrin Inclusion Complex: Preparation, Characterization and Molecular Docking Studies

Sivakumar¹

2015

SOJMSE

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“…Much attention has been focused on the recent developments in materials science based on supramolecular chemistry, especially those dealing with polyrotaxane molecules [2][3][4]. Materials consisting of cross-linked polyrotaxane or cross-linked polyrotaxane blends are called "slide-ring materials" [2,3].…”

Section: Introductionmentioning

confidence: 99%

Preparation of Polyrotaxane Fibers. Part II: Tensile Properties of Polyrotaxane Fibers Treated with Two Cross-linking Reagents

Katsuyama

Shimizu

Sato

et al. 2009

Textile Research Journal

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Polyrotaxane fibers prepared with wet spinning of polyrotaxane consisting of poly(ethylene glycol) and cyclodextrins (CDs) were cross-linked with two different cross-linking reagents, i.e., divinyl sulfone (DVS) and ethylene glycol diglycidyl ether (EGDE), to improve tensile properties of the fibers. By cross-linking with DVS, the values for the tenacity at break and the initial modulus were increased with cross-linking time, while the elongation at break was improved only moderately. On the other hand, drastic improvements in elongation at break were observed after EGDE cross-linking, up to 645% of its original length, although the tenacity at break and the initial modulus showed only slight improvements. After cross-linking, only minor changes in the degree of crystallinity fibers were observed by wide-angle X-ray scattering (WAXS) measurements.Keywords: polyrotaxane fibers, cyclodextrins, cross-linking, tensile measurements -2 - IntroductionIn our previous paper [1] on the functional polyrotaxane fibers, we reported a successful preparation of pure polyrotaxane fibers by wet spinning from polyrotaxane dope solution in various polyrotaxane solvents, i.e., dimethylsulfoxide (DMSO), dimethylacetamide (DMAc) containing lithium chloride (LiCl), and dimethylformamide (DMF) containing LiCl. Electron microscopy observations revealed a smooth and crack-free surface texture of the as-spun polyrotaxane fibers. By tensile measurements, the fibers spun from these three solvent systems showed similar levels of initial modulus and tenacity at break, whose values were relatively lower than those of commercial fibers such as polyesters and rayons. The values for elongation at break, however, were extremely high: up to 388% at 50% RH and 972% at 95% RH. The fiber spun from the DMSO dope solution showed a higher value of the elongation at break than the fibers from DMF/LiCl and DMAc/LiCl. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 -3 -The results also imply a successful preparation of novel spandex-like fibers exhibiting high levels of elongation at break and elastomeric properties.Cross-linking treatments of spun fibers are widely used for the preparation of functional fibers and improvements in physical properties of fibers. For example, previous studies showed remarkable improvements in wet and dry mechanical properties of chitosan fibers by cross-linking [7,8]. Poly(vinyl alcohol) fibers cross-linked with boric acid also showed improved strength and Young's modulus [9]. Cross-linking treatments are also applied to the preparation of rayons [10] and ultra-high-molecular weight polyethylene fibers [11] with improved physical properties, as well as finishing of fabrics such as crease-resistant finishing [12]. Recent investigations have utilized novel bio-mimetic cross-linking mechanisms, mediated by the action of enzymes or oxidation ...

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Biomedical Applications of Cyclodextrin Based Polyrotaxanes

Cited by 149 publications

References 156 publications

Supramolecular Polymers Based on Cyclodextrins for Drug and Gene Delivery

Supramolecular Polymers Based on Cyclodextrins for Drug and Gene Delivery

Salicylanilide /Cyclodextrin Inclusion Complex: Preparation, Characterization and Molecular Docking Studies

Preparation of Polyrotaxane Fibers. Part II: Tensile Properties of Polyrotaxane Fibers Treated with Two Cross-linking Reagents

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