Biomedical Applications of Electrospun Polymer Composite Nanofibres

Deshmukh, Kalim; Sankaran, Sowmya; Ahamed, M. Basheer; Pasha, S. K. Khadheer

doi:10.1007/978-3-030-04741-2_5

Cited by 6 publications

(3 citation statements)

References 165 publications

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“…The two most important biopolymers are chitosan and silk fibroin when dealing with biofunctionalized nanomaterials, since they allow various antimicrobial agents to be attached via the numerous functional groups present. The antimicrobial peptides (AMPs) bound to the surface of the nanofibers are studied widely [164][165][166]. Due to the biocompatibility offered by the AMPs, they have now become one of the most utilized antimicrobial additives for wound dressings.…”

Section: Biofunctionalized Antibacterial Nanofibersmentioning

confidence: 99%

“…For the AMP to be immobilized on the surface of the nanofiber, numerous approaches are utilized. Co-spinning and covalent binding are approaches implemented in producing the nanofibers with AMP immobilized onto the surface [166]. The process of covalent immobilization provides the best process, as this leads to negligible leaching of the AMP and long-term stability and nontoxicity [167].…”

Section: Biofunctionalized Antibacterial Nanofibersmentioning

confidence: 99%

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Electrospun Antibacterial Nanomaterials for Wound Dressings Applications

et al. 2021

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Chronic wounds are caused by bacterial infections and create major healthcare discomforts; to overcome this issue, wound dressings with antibacterial properties are to be utilized. The requirements of antibacterial wound dressings cannot be fulfilled by traditional wound dressing materials. Hence, to improve and accelerate the process of wound healing, an antibacterial wound dressing is to be designed. Electrospun nanofibers offer a promising solution to the management of wound healing, and numerous options are available to load antibacterial compounds onto the nanofiber webs. This review gives us an overview of some recent advances of electrospun antibacterial nanomaterials used in wound dressings. First, we provide a brief overview of the electrospinning process of nanofibers in wound healing and later discuss electrospun fibers that have incorporated various antimicrobial agents to be used in wound dressings. In addition, we highlight the latest research and patents related to electrospun nanofibers in wound dressing. This review also aims to concentrate on the importance of nanofibers for wound dressing applications and discuss functionalized antibacterial nanofibers in wound dressing.

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Section: Biofunctionalized Antibacterial Nanofibersmentioning

confidence: 99%

Section: Biofunctionalized Antibacterial Nanofibersmentioning

confidence: 99%

Electrospun Antibacterial Nanomaterials for Wound Dressings Applications

et al. 2021

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“…Polyvinyl alcohol (PVA) is toxicity-free polymer featuring goood physical properties, thermal stability, and flexibility, and therefore PVA has a widespread acceptance in different fields, involving livlihood, industry, food, and packagings [20][21][22][23][24][25][26][27]. In addition, PVA has biodegradability, biocompatibility, high hydrophilicity, and non-toxicity, due to which PVA has been commonly used in the medicine [28,29]. Asran et al employed elelctrospinning to produce PVA/PHB electrospun films with an attempt to become skin substitute [30].…”

Section: Introductionmentioning

confidence: 99%

Biodegradable and conductive PVA/CNT nanofibrous membranes used in nerve conduit applications

Jhang

Lin

Lou

et al. 2021

Journal of Industrial Textiles

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The recovery of impaired peripheral nerves is often not as expected, which makes the development of nerve conduits trendy nowadays. To enable the neural messages effectively being delivered as well as to prevent the secondary damage during the removal of nerve conduits, the conductivity and biodegradability are two essential requirements for ideal nerve conduits. In this study, electrospinning is used to produce polyvinyl alcohol (PVA)/carbon nanotubes (CNT) electrospun films, after which the morphology analysis, electrical property, water contact angle, and biological characteristics of the membranes are investigated, thereby determining the optimal nerve conduits based on the employment of electrospinning, PVA, and CNT. The test results indicate that with 0.25 wt% of PVA, the electrospun films exhibit comparatively lower resistance of 25.3 ohm, good fibrous morphology with a diameter being 1 μm. In addition, the electrospun films are cytotoxicity-free and facilitate the growth of cells. It is observed in the MMT assay that after co-cultured with cells for three days, PVA/CNT electrospinning fibrous membranes exhibit a cellular viability that is 18.5 times greater than that of the control group on Day 1. According to all property evaluations, PVA/CNT electrospinning fibrous membranes are a qualified candidate for the use of nervous conduits.

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