Biomedical applications of hydrogels in drug delivery system: An update

Kesharwani, Payal; Bisht, Akansha; Alexander, Amit; Dave, Vivek S; Sharma, Swapnil

doi:10.1016/j.jddst.2021.102914

Cited by 138 publications

(85 citation statements)

References 308 publications

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“…Statins are reported to elicit wound healing [ 4 , 5 ] beyond their much-claimed cholesterol-reducing effects. More than one biological mechanism has been attributed to their role in cutaneous tissue regeneration, including pro-lymphangiogenic, pro-angiogenic, antiinflammatory, antifibrotic, antibacterial, and immunomodulatory effects [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Self-Gelling Solid Lipid Nanoparticle Hydrogel Containing Simvastatin as Suitable Wound Dressing: An Investigative Study

Gupta

Sharma

et al. 2022

Gels

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Hydrogels, an advanced interactive system, is finding use as wound dressings, however, they exhibit restricted mechanical properties, macroscopic nature, and may not manage high exudate wounds or incorporate lipophilic actives. In this study, we developed a self-gelling solid lipid nanoparticle (SLNs) dressing to incorporate simvastatin (SIM), a lipophilic, potential wound-healing agent, clinically limited due to poor solubility (0.03 mg/mL) and absorption. The study explores unconventional and novel application of SIM. The idea was to incorporate a significant amount of SIM in a soluble form and release it slowly over a prolonged time. Further, a suitable polymeric surfactant was selected that assigned a self-gelling property to SLNs (SLN-hydrogel) so as to be used as a novel wound dressing. SLNs assign porosity, elasticity, and occlusivity to the dressing to keep the wound area moist. It will also provide better tolerance and sensory properties to the hydrogel. SIM loaded SLN-hydrogel was prepared employing an industry amenable high-pressure homogenization technique. The unique hydrogel dressing was characterized for particle size, zeta potential, Fourier transform infra-red spectroscopy, powder X-ray diffraction, differential scanning calorimetry, rheology, and texture. Significant loading of SIM (10% w/w) was achieved in spherical nanoparticule hydrogel (0.3 nm (nanoparticles) to2 µm (gelled-matrix)) that exhibited good spreadability and mechanical properties and slow release up to 72 h. SLN-hydrogel was safe as per the organization for economic co-operation and development (OECD-404) guidelines, with no signs of irritation. Complete healing of excision wound observed in rats within 11 days was 10 times better than marketed povidone-iodine product. The presented work is novel both in terms of classifying a per se SLN-hydrogel and employing SIM. Further, it was established to be a safe, effective, and industry amenable invention.

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Section: Introductionmentioning

confidence: 99%

Self-Gelling Solid Lipid Nanoparticle Hydrogel Containing Simvastatin as Suitable Wound Dressing: An Investigative Study

Gupta

Sharma

et al. 2022

Gels

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“…Polyelectrolyte complex (PEC) hydrogels [1][2][3][4][5][6][7][8][9][10][11][12] present an exciting platform for development of soft materials to cater to diverse applications in biomedicine [13,14] as scaffolds for tissue engineering, [15][16][17][18] bioadhesives, [19][20][21][22][23][24][25][26] and drug delivery, [27][28][29][30][31] as well as ionic conductors [32,33] and in food industries. [34,35] These hydrogels self-assemble rapidly [1,9] upon mixing of oppositely charged block polyelectrolytes and exhibit hierarchical microstructures, [4,5,[36][37][38][39] comprising three-dimensional networks of PEC domains (composed of the oppositely charged blocks) connected to each other via the neutral blocks.…”

Section: Introductionmentioning

confidence: 99%

Polyelectrolyte Complex-Covalent Interpenetrating Polymer Network Hydrogels

Göckler

Schepers

et al. 2022

Preprint

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Polyelectrolyte complex (PEC) hydrogels possess a rich microstructural diversity and tunability of shear response, self-healing attributes, and pH- and salt-responsiveness. Yet, their utility in biotechnology and biomedicine has been limited, owing to their weak mechanical strength and uncontrolled swelling. Here, we introduce a strategy to overcome these drawbacks of PEC hydrogels by interlacing the electrostatically crosslinked PEC network with a covalently crosslinked polymer network, creating polyelectrolyte complex-covalent interpenetrating polymer network (PEC-IPN) hydrogels. In the PEC-IPN hydrogels demonstrated here, composed of oppositely charged ABA triblock copolymers and photocrosslinkable 4-arm poly(ethylene oxide) (PEO), the PEC network self-assembles swiftly in aqueous environs, providing structural rigidity and serving as protective scaffoldings for the covalently crosslinkable PEO precursors. Photocrosslinking of the PEO chains creates a covalent network, supplying structural reinforcement to the PEC network. The resulting PEC-IPN hydrogels possess significantly improved shear and tensile strength, swelling characteristics, and mechanical stability in saline environments while preserving the intrinsic features of PEC networks, including the mesoscale network structure and salt-responsiveness. We envision that our approach to produce PEC based IPN hydrogels will pave the way for creation of self-assembled hybrid materials that harness the unique attributes of electrostatic self-assembly pathways, with broad applications in biomedicine.

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“…According to the survey done by researchers, the characteristic features of hydrogels including biodegradability, swelling property and biocompatibility can be controlled and modi ed by the type of polymers and preparation procedures [20], rapid hydrogel formation as well as gelation capability were regulated by the association of polymeric network and functional groups of the polymers used [21]. It is also stated by J. Leijten et al [6], hydrogels as a biopolymer exceptionally forms a network where the crosslinking of chains are bonded either covalently or make a non-covalent interaction [22], the formed cross link of the hydrogels grants to be a permeable network that allows the movement of molecules like loaded drugs, important nutrients and oxygen through the intertwined structure.…”

Section: Introductionmentioning

confidence: 99%

Preparation Characterization and Blood Compatibility Studies of Silk Fibroin / Gelatin / Curcumin based Injectable Hydrogels

Akulo

Adalı

Ebedal

2022

Preprint

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Background Hydrogel is a structure with three-dimension that have the potential to absorb and retain water inside of it. Currently hydrogels made from natural biopolymers are preferred in the discipline of biomedicine due to their nature of blood compatibility, adhesion of platelets and protein binding, ease of administration and delivery of ingredients to the place of action. The purpose of this study is preparing blood compatible injectable hydrogels from naturally obtained polymers of biomaterials in a combination of different proportion, characterizing and analyzing its physiochemical blood compatibility and morphological structures. Methods Three different compositions of gelatin, dialyzed SF, curcumin and N, N methylene bisacrylamide (MBA) in different groups coded by IVA, IVB and IVC were used. The combinations were evenly mixed on a magnetic stirrer. After an hour of the gelation process it has been kept under refrigerator at 4°C. For characterization and biocompatibility studies of hydrogel swelling test and biodegradation analysis, SEM, FTIR, In-vitro coagulation tests, total serum albumin and cholesterol level analysis were applied, Results Injectable hydrogel successfully made from the combinations of SF/GE/CU/ in the presence of a cross linker MBA and the result from physiochemical biocompatibility and morphological characteristics study were confirmed that natural biopolymers used in this study are a candidate for biomedical applications. Conclusion The result confirmed that the composition coded by IVC was identified the most stable composition and suitable in its morphological structure with excellent blood compatible nature recommended for further biomedical applications.

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Biomedical applications of hydrogels in drug delivery system: An update

Cited by 138 publications

References 308 publications

Self-Gelling Solid Lipid Nanoparticle Hydrogel Containing Simvastatin as Suitable Wound Dressing: An Investigative Study

Self-Gelling Solid Lipid Nanoparticle Hydrogel Containing Simvastatin as Suitable Wound Dressing: An Investigative Study

Polyelectrolyte Complex-Covalent Interpenetrating Polymer Network Hydrogels

Preparation Characterization and Blood Compatibility Studies of Silk Fibroin / Gelatin / Curcumin based Injectable Hydrogels

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