Biomedical applications of metal oxide nanoparticles in aging and age-associated diseases

Yadav, Somu; Maurya, Pawan Kumar

doi:10.1007/s13205-021-02892-8

Cited by 18 publications

(2 citation statements)

References 77 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent studies have revealed that materials and their oxides can exhibit antioxidant properties when used in the form of nanomaterials. Specific metal oxide nanoparticles, like CeO 2 , selenium (Se), and Cu 5.4 O, demonstrate capabilities akin to antioxidant enzymes such as superoxide dismutase (SOD), catalase, and glutathione peroxidase [156][157][158]. Selenium nanoparticles (SeNPs) are acknowledged for their robust anticancer, antibacterial, antimicrobial, antiviral, anti-inflammatory, and antioxidant characteristics, all of which notably influence the process of wound healing.…”

Section: Novel Metallic Nanomaterialsmentioning

confidence: 99%

Advancements in Regenerative Hydrogels in Skin Wound Treatment: A Comprehensive Review

Olteanu,

Neacșu,

Joița

et al. 2024

IJMS

View full text Add to dashboard Cite

This state-of-the-art review explores the emerging field of regenerative hydrogels and their profound impact on the treatment of skin wounds. Regenerative hydrogels, composed mainly of water-absorbing polymers, have garnered attention in wound healing, particularly for skin wounds. Their unique properties make them well suited for tissue regeneration. Notable benefits include excellent water retention, creating a crucially moist wound environment for optimal healing, and facilitating cell migration, and proliferation. Biocompatibility is a key feature, minimizing adverse reactions and promoting the natural healing process. Acting as a supportive scaffold for cell growth, hydrogels mimic the extracellular matrix, aiding the attachment and proliferation of cells like fibroblasts and keratinocytes. Engineered for controlled drug release, hydrogels enhance wound healing by promoting angiogenesis, reducing inflammation, and preventing infection. The demonstrated acceleration of the wound healing process, particularly beneficial for chronic or impaired healing wounds, adds to their appeal. Easy application and conformity to various wound shapes make hydrogels practical, including in irregular or challenging areas. Scar minimization through tissue regeneration is crucial, especially in cosmetic and functional regions. Hydrogels contribute to pain management by creating a protective barrier, reducing friction, and fostering a soothing environment. Some hydrogels, with inherent antimicrobial properties, aid in infection prevention, which is a crucial aspect of successful wound healing. Their flexibility and ability to conform to wound contours ensure optimal tissue contact, enhancing overall treatment effectiveness. In summary, regenerative hydrogels present a promising approach for improving skin wound healing outcomes across diverse clinical scenarios. This review provides a comprehensive analysis of the benefits, mechanisms, and challenges associated with the use of regenerative hydrogels in the treatment of skin wounds. In this review, the authors likely delve into the application of rational design principles to enhance the efficacy and performance of hydrogels in promoting wound healing. Through an exploration of various methodologies and approaches, this paper is poised to highlight how these principles have been instrumental in refining the design of hydrogels, potentially revolutionizing their therapeutic potential in addressing skin wounds. By synthesizing current knowledge and highlighting potential avenues for future research, this review aims to contribute to the advancement of regenerative medicine and ultimately improve clinical outcomes for patients with skin wounds.

show abstract

Section: Novel Metallic Nanomaterialsmentioning

confidence: 99%

Advancements in Regenerative Hydrogels in Skin Wound Treatment: A Comprehensive Review

Olteanu,

Neacșu,

Joița

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

“…Selected metal oxide nanoparticles, such as CeO 2 , behave as antioxidant enzymes, that is, nanozymes in pathological conditions, such as superoxide dismutase, catalase and glutathione peroxidase. Nanozymes have substantial catalytically active surface atoms and thus are highly active, whereas natural enzymes usually have only one active centre, thus making them more efficient in catalytic reactions than natural enzymes 85–88 …”

Section: Scavenging Excessive Rosmentioning

confidence: 99%

Anti‐inflammatory hydrogel dressings and skin wound healing

Huang

Dong

Zhao

et al. 2022

Clinical & Translational Med

178

View full text Add to dashboard Cite

Hydrogels are promising and widely utilized in the biomedical field. In recent years, the anti‐inflammatory function of hydrogel dressings has been significantly improved, addressing many clinical challenges presented in ongoing endeavours to promote wound healing. Wound healing is a cascaded and highly complex process, especially in chronic wounds, such as diabetic and severe burn wounds, in which adverse endogenous or exogenous factors can interfere with inflammatory regulation, leading to the disruption of the healing process. Although insufficient wound inflammation is uncommon, excessive inflammatory infiltration is an almost universal feature of chronic wounds, which impedes a histological repair of the wound in a predictable biological step and chronological order. Therefore, resolving excessive inflammation in wound healing is essential. In the past 5 years, extensive research has been conducted on hydrogel dressings to address excessive inflammation in wound healing, specifically by efficiently scavenging excessive free radicals, sequestering chemokines and promoting M1‐to‐M2 polarization of macrophages, thereby regulating inflammation and promoting wound healing. In this study, we introduced novel anti‐inflammatory hydrogel dressings and demonstrated innovative methods for their preparation and application to achieve enhanced healing. In addition, we summarize the most important properties required for wound healing and discuss our analysis of potential challenges yet to be addressed.

show abstract

Scalable Production of Metal Oxide Nanoparticles for Optoelectronics Applications

Rebecchi,

Martin,

Albo

et al. 2024

Chemistry A European J

View full text Add to dashboard Cite

This work describes the scalability process of a continuous‐injection protocol employed to produce tin‐doped indium oxide nanocrystal dispersions. Different levels of manipulation starting from the synthesis and processing also related to the tuning of the optical response (considering the peculiar combination of UV and NIR absorption with visible transparency) make these materials incredibly versatile. But one of the most attractive features concern the modulation of their charge carrier density through chemical or post‐synthetic doping, as for the case of core‐shell materials, expanding the properties of the core composition. In addition, the colloidal nature of such materials allows for easy solution processing which enables an extensive use in different applications within current thin films base technologies.

show abstract

Biomedical applications of metal oxide nanoparticles in aging and age-associated diseases

Cited by 18 publications

References 77 publications

Advancements in Regenerative Hydrogels in Skin Wound Treatment: A Comprehensive Review

Advancements in Regenerative Hydrogels in Skin Wound Treatment: A Comprehensive Review

Anti‐inflammatory hydrogel dressings and skin wound healing

Scalable Production of Metal Oxide Nanoparticles for Optoelectronics Applications

Contact Info

Product

Resources

About