Biomedical Applications of Plant Extract-Synthesized Silver Nanoparticles

Abstract

Silver nanoparticles (AgNPs) have attracted a lot of interest directed towards biomedical applications due in part to their outstanding anti-microbial activities. However, there have been many health-impacting concerns about their traditional synthesis methods, i.e., the chemical and physical methods. Chemical methods are commonly used and contribute to the overall toxicity of the AgNPs, while the main disadvantages of physical synthesis include high production costs and high energy consumption. The biological methods provide an economical and biocompatible option as they use microorganisms and natural products in the synthesis of AgNPs with exceptional biological properties. Plant extract-based synthesis has received a lot of attention and has been shown to resolve the limitations associated with chemical and physical methods. AgNPs synthesized using plant extracts provide a safe, cost-effective, and environment-friendly approach that produces biocompatible AgNPs with enhanced properties for use in a wide range of applications. The review focused on the use of plant-synthesized AgNPs in various biomedical applications as anti-microbial, anti-cancer, anti-inflammatory, and drug-delivery agents. The versatility and potential use of green AgNPs in the bio-medicinal sector provides an innovative alternative that can overcome the limitations of traditional systems. Thus proving green nanotechnology to be the future for medicine with continuous progress towards a healthier and safer environment by forming nanomaterials that are low- or non-toxic using a sustainable approach.

Complexes of Ag and ZnO nanoparticles with BBR for enhancement of gastrointestinal antibacterial activity through the impacts of size and composition

“…Ag NPs can be prepared by eco-friendly techniques using plant extracts, and biological or microbial agents instead of highly toxic reducing chemicals to meet the strict requirements in bio-applications. 16 Zinc oxide nanoparticles (ZnO NPs) are recognized as a bio-safe nanomaterial applied in biology and medicine with some interesting possibilities such as antitumor, antimicrobial, antifungal and anti-inammatory activities, wound healing ability, antidiabetic properties, etc. 17,18 It was reported that the minimum inhibitory concentration of biosynthesized Ag and ZnO NPs against various bacterial strains varied in the ranges of 31.25 O 62.5 mg L −1 and 440 O 854 mg L −1 , respectively.…”

Biogenic Synthesis of Zinc Oxide Nanoparticles Using Citrullus colocynthis for Potential Biomedical Applications

“…Moreover, nanoparticles produced by green synthesis are biocompatible because of the involvement of biomolecules as reducing agents. Furthermore, green synthesis methods are simple, easy, cost-effective, and environmentally friendly [ 6 , 7 , 8 ].…”

Enhancement of Cell Behavior by the Polysaccharide Extract of Arthrospira and Potential Biomedical Applications

“…Meanwhile, published articles on the effects of AdSP on cell behavior are mainly focused on the inhibition of tumor cell proliferation, anti-angiogenesis, enhancement of hematopoietic stem cells, etc. [ 12 , 13 , 14 ]. Only one study focuses on the effects of AdSP on the behavior of neural stem cells [ 15 ].…”