Biomedical Applications of Polyhydroxyalkanoates

Ray, Subhasree; Kalia, Vipin Chandra

doi:10.1007/s12088-017-0651-7

Cited by 131 publications

(65 citation statements)

References 112 publications

(139 reference statements)

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“…Both scl and mcl-PHAs have been used for various biomedical applications such as tissue engineering, medical device development and drug delivery studies. Cardiac patches, various drug carriers, vascular grafts, nerve conduits, heart valves, artificial blood vessels, subcutaneous implants, orthopaedic pins, stents, wound dressings, slings have been developed based on PHAs [11,12]. Moreover, P(4HB) has obtained FDA approval for clinical application as absorbable sutures in 2007 [13].…”

Section: Introductionmentioning

confidence: 99%

Biosynthesis and characterization of a novel, biocompatible medium chain length polyhydroxyalkanoate by Pseudomonas mendocina CH50 using coconut oil as the carbon source

Basnett

Marcello

Lukasiewicz

et al. 2018

J Mater Sci: Mater Med

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This study validated the utilization of triacylglycerides (TAGs) by Pseudomonas mendocina CH50, a wild type strain, resulting in the production of novel mcl-PHAs with unique physical properties. A PHA yield of 58% dcw was obtained using 20g/L of coconut oil. Chemical and structural characterisation confirmed that the mcl-PHA produced was a terpolymer comprising of three different repeating monomer units, 3hydroxyoctanoate, 3-hydroxydecanoate and 3-hydroxydodecanoate or P(3HO-3HD-3HDD). Bearing in mind the potential of P(3HO-3HD-3HDD) in biomedical research, especially in neural tissue engineering, in vitro biocompatibility studies were carried out using NG108-15 (neuronal) cells. Cell viability data confirmed that P(3HO-3HD-3HDD) supported the attachment and proliferation of NG108-15 and was therefore, confirmed to be biocompatible in nature and suitable for neural regeneration.

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Section: Introductionmentioning

confidence: 99%

Biosynthesis and characterization of a novel, biocompatible medium chain length polyhydroxyalkanoate by Pseudomonas mendocina CH50 using coconut oil as the carbon source

Basnett

Marcello

Lukasiewicz

et al. 2018

J Mater Sci: Mater Med

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“…Biopolymers [ 11 ], such as poly (lactic acid) (PLA) [ 12 , 13 ], polyhydroxybutyrate (PHB) [ 14 ] and thermoplastic starch (TPS) [ 15 ], are increasingly used in the food packaging and agricultural sector, in addition to other fields of application such as medical [ 16 , 17 , 18 ] or composite materials [ 18 , 19 , 20 ]. However, consumers have low information about where they have to throw away this kind of plastics after their useful life and they are commonly disposed of with traditional waste plastics [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Interference of Biodegradable Plastics in the Polypropylene Recycling Process

et al. 2018

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Recycling polymers is common due to the need to reduce the environmental impact of these materials. Polypropylene (PP) is one of the polymers called ‘commodities polymers’ and it is commonly used in a wide variety of short-term applications such as food packaging and agricultural products. That is why a large amount of PP residues that can be recycled are generated every year. However, the current increasing introduction of biodegradable polymers in the food packaging industry can negatively affect the properties of recycled PP if those kinds of plastics are disposed with traditional plastics. For this reason, the influence that generates small amounts of biodegradable polymers such as polylactic acid (PLA), polyhydroxybutyrate (PHB) and thermoplastic starch (TPS) in the recycled PP were analyzed in this work. Thus, recycled PP was blended with biodegradables polymers by melt extrusion followed by injection moulding process to simulate the industrial conditions. Then, the obtained materials were evaluated by studding the changes on the thermal and mechanical performance. The results revealed that the vicat softening temperature is negatively affected by the presence of biodegradable polymers in recycled PP. Meanwhile, the melt flow index was negatively affected for PLA and PHB added blends. The mechanical properties were affected when more than 5 wt.% of biodegradable polymers were present. Moreover, structural changes were detected when biodegradable polymers were added to the recycled PP by means of FTIR, because of the characteristic bands of the carbonyl group (between the band 1700–1800 cm−1) appeared due to the presence of PLA, PHB or TPS. Thus, low amounts (lower than 5 wt.%) of biodegradable polymers can be introduced in the recycled PP process without affecting the overall performance of the final material intended for several applications, such as food packaging, agricultural films for farming and crop protection.

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“…Due to their lower crystallinity, P (3HB-4HB) were employed for drug delivery and making medical devices such as: rivets, tacks, pins, sutured fastener etc. [15]. PHA co-polymers produced by Pseudomonas fluoroscenes act as immobilizing agent in clinical diagnostics [16].…”

Section: Discussionmentioning

confidence: 99%

“…PHA co-polymers produced by Pseudomonas fluoroscenes act as immobilizing agent in clinical diagnostics [16]. Aeromonas hydrophila produces PHA copolymers poly-3-hydroxybutyrate-hydoxyhexanoate (PHB-HHx), which are useful in preparing vessel stent [15]. Poly-3-hydroxy-actylthioalkanoate-co-3-hydroxyalkanoate used as antibacterial agent against Staphylococcus aureus [17,18].…”

Section: Discussionmentioning

confidence: 99%

Co-utilization of Crude Glycerol and Biowastes for Producing Polyhydroxyalkanoates

2017

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Polyhydroxyalkanoate (PHA) production by EGU45 and defined mixed culture of spp. were studied by using crude glycerol (CG) and hydrolyzed biowastes as feed material. Hydrolysates from onion peels (OP), potato peels, pea-shells (PS), apple pomace 2% total solids obtained with defined mixed hydrolytic cultures (MHC2) were inoculated with EGU45 and defined mixed bacterial cultures (5MC1), which produced PHA at the rate of 40-350 and 65-450 mg/L, respectively. Addition of CG (1%, v/v) to these hydrolysates resulted in 1.8-fold and 4.5-fold enhancement in PHA production from OP by EGU45 and 5MC1, respectively. Co-utilization of OP and PS (in 2:1 ratio) supplemented with CG (1%, v/v) by EGU45 resulted in 2-fold increase in PHA production in comparison to OP + CG. This co-metabolism of OP and PS also enabled PHA co-polymer production (1300 mg/L), having an enhanced HV content of 21.2% (w/w).

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Biomedical Applications of Polyhydroxyalkanoates

Cited by 131 publications

References 112 publications

Biosynthesis and characterization of a novel, biocompatible medium chain length polyhydroxyalkanoate by Pseudomonas mendocina CH50 using coconut oil as the carbon source

Biosynthesis and characterization of a novel, biocompatible medium chain length polyhydroxyalkanoate by Pseudomonas mendocina CH50 using coconut oil as the carbon source

Interference of Biodegradable Plastics in the Polypropylene Recycling Process

Co-utilization of Crude Glycerol and Biowastes for Producing Polyhydroxyalkanoates

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