Biomedical,clinical and environmental applications of platinum-based nanohybrids: An updated review

Yerpude, Sachin T.; Potbhare, Ajay K.; Bhilkar, P.R.; Alok, R.; Singh, Raghvendra Pratap; Abdala, Ahmed; Adhikari, Rameshwar; Sharma, Rohit; Chaudhary, Ratiram Gomaji

doi:10.1016/j.envres.2023.116148

Cited by 19 publications

(3 citation statements)

References 243 publications

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“…Nanomaterials are important class of materials for removing the toxic HMs from polluted water. [107][108][109] Basically, HMs are deadly toxic and harmful for human being and ecology too. Particularly, HMs like Mercury (Hg), Chromium (Cr), Cadmium (Cd), Arsenic (As), Thallium (Tl), Lead (Pb), Zinc (Zn), Nickel (Ni) are responsible for several panic diseases to human-being, animals and plants.…”

Section: Nanomaterials As Adsorbentsmentioning

confidence: 99%

Review on Agrobiowaste‐mediated Nanohybrids for Removal of Toxic Heavy Metals from Wastewater

Chaudhary,

Singh,

Daddemal‐Chaudhary

et al. 2024

ChemistrySelect

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Because of the growing population and the industrial revolution, a significant number of toxic materials including heavy metals (HMs) are being released into the environment, posing harm to humans, the environment, and other living organisms. When these HMs find their way into water sources, they cause water pollution and pose a threat to the ecosystem. As a result, there is an imperative need to eliminate these HMs from the water. Numerous techniques are being employed for water purification, but adsorption is the most economical and efficient method. The present article critically discussed the applications of different adsorbents including agricultural wastes, industrial wastes, biochar, chitosan, aerogel‐based adsorbents, geopolymer cement/concrete, carbon‐based nanomaterials (NMs), and polymer‐supported nanocomposites (NCs) for removal of HMs from wastewater. Removal capacity of some of the adsorbents are tabulated. Effects of dose of adsorbent, contact time, pH, temperature, initial ion concentration and ionic strength on the removal of HMs from water have been explored. Various adsorption isotherm and kinetic models have also been discussed, including the modeling using artificial neural networks.

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Section: Nanomaterials As Adsorbentsmentioning

confidence: 99%

Review on Agrobiowaste‐mediated Nanohybrids for Removal of Toxic Heavy Metals from Wastewater

Chaudhary,

Singh,

Daddemal‐Chaudhary

et al. 2024

ChemistrySelect

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“…Numerous studies have used metallic elements or compounds for cancer treatment. They are neither essential elements but noble metals to have no cytotoxicity nor are chemically active in the metabolism, [ 17–22 ] such as Au nanoparticles (NPs). Essential metal‐ion‐based nanomaterials can also function as anticancer nanomedicine therapy alone without being in ion form, such as modified Fe 3 O 4 NPs with magnetic–thermal conversion ability.…”

Section: Introductionmentioning

confidence: 99%

A Brief Review on Manipulation of Essential Metal Ions as Nanomedicine for Cancer Therapy

Weng,

Chen

2023

Advanced NanoBiomed Research

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In this review, the latest progress in essential metal‐ion‐based nanomedicines for tumor therapy is summarized, existing challenges are addressed, and possible directions are proposed for such therapeutic strategies. Essential metal ions are critical for the metabolic activity of organisms. Their abnormal spatial and temporal distribution in biological systems, particularly inside the cell, disrupts biochemical processes and leads to irreversible physicochemical damage to cells. Thus, they can function as the foundation of targeted cancer therapies for tumor inhibition and eradication. Over the last decade, numerous essential metal‐ion‐based cancer therapies have been developed to fight a wide spectrum of cancers with improved efficiency and minor drug resistance. Triggering biocatalysis, affecting protein metabolism, interfering with signal transduction, damaging DNA, and initiating biomineralization are the main mechanisms underlying these therapies. In this study, it is aimed to provide readers with general implications for future research for an increased interest in future clinical applications of these advanced cancer therapies.

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“…The concept of theranostics has been offered to overcome various limitations in drug delivery systems by concurrently combining monitoring and treatment of diseases 11,12 . Advancements in nanotechnology have enabled the creation of nanostructures, both two-dimensional (2D) and 3D, that incorporate diverse biomaterials [13][14][15][16][17] . Consequently, the NPs, having a size range of 1-100 nm represent a promising approach to address the systemic toxicity and limitations around drug delivery across the BBB 18 .…”

mentioning

confidence: 99%

Antiepileptic drug-loaded and multifunctional iron oxide@silica@gelatin nanoparticles for acid-triggered drug delivery

Ghane,

Khalili,

Khorasani

et al. 2024

Sci Rep

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The current study developed an innovative design for the production of smart multifunctional core-double shell superparamagnetic nanoparticles (NPs) with a focus on the development of a pH-responsive drug delivery system tailored for the controlled release of Phenytoin, accompanied by real-time monitoring capabilities. In this regard, the ultra-small superparamagnetic iron oxide@silica NPs (IO@Si MNPs) were synthesized and then coated with a layer of gelatin containing Phenytoin as an antiepileptic drug. The precise saturation magnetization value for the resultant NPs was established at 26 emu g-1. The polymeric shell showed a pH-sensitive behavior with the capacity to regulate the release of encapsulated drug under neutral pH conditions, simultaneously, releasing more amount of the drug in a simulated tumorous-epileptic acidic condition. The NPs showed an average size of 41.04 nm, which is in the desired size range facilitating entry through the blood–brain barrier. The values of drug loading and encapsulation efficiency were determined to be 2.01 and 10.05%, respectively. Moreover, kinetic studies revealed a Fickian diffusion process of Phenytoin release, and diffusional exponent values based on the Korsmeyer-Peppas equation were achieved at pH 7.4 and pH 6.3. The synthesized NPs did not show any cytotoxicity. Consequently, this new design offers a faster release of PHT at the site of a tumor in response to a change in pH, which is essential to prevent epileptic attacks.

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Biomedical,clinical and environmental applications of platinum-based nanohybrids: An updated review

Cited by 19 publications

References 243 publications

Review on Agrobiowaste‐mediated Nanohybrids for Removal of Toxic Heavy Metals from Wastewater

Review on Agrobiowaste‐mediated Nanohybrids for Removal of Toxic Heavy Metals from Wastewater

A Brief Review on Manipulation of Essential Metal Ions as Nanomedicine for Cancer Therapy

Antiepileptic drug-loaded and multifunctional iron oxide@silica@gelatin nanoparticles for acid-triggered drug delivery

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