Biomedical Materials for Regenerating Bone Tissue Utilizing Marine Invertebrate

Oh, Gun‐Woo; Jung, Won‐Kyo

doi:10.5657/kfas.2015.0001

Cited by 4 publications

(1 citation statement)

References 98 publications

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“…32,46 Calcium and phosphate have essential metabolic functions in bone and help maintain blood hemostasis. 47 There were no statistical differences in serum ALP, calcium, or phosphate levels between the BMP-2 (–) and BMP-2 (+) groups. Therefore, LSS loaded with BMP-2 did not have systemic influence.…”

Section: Discussionmentioning

confidence: 79%

Bone regeneration by bone morphogenetic protein-2 from porous beads with leaf-stacked structure for critical-sized femur defect model in dogs

Hong

Lee

et al. 2020

J Biomater Appl

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The objective of this study was to investigate whether porous beads with a leaf-stacked scaffold loaded with bone morphogenetic protein-2, with sustained release for up to four weeks, were beneficial to a dog model of critical long bone defects and capable of promoting bone regeneration without side effects. Critical long bone defects were created in the femoral diaphyses of 21 dogs. Each critical defect was fixed with an intramedullary pin and an universal locking plate. Leaf-stacked scaffold beads were implanted into the defect, which was covered with a membrane. Nineteen samples were evaluated 4, 8, and 12 weeks after surgery using simple radiographs, serum chemistry measurements, histological staining, and gene expression analysis. Sustained bone morphogenetic protein-2 release from the leafstacked scaffold continued for four weeks and consistently affected the expression of early and late osteogenesis factors. The results suggest that sustained bone morphogenetic protein-2 release is effective for bone regeneration, with minimal side effects.

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Section: Discussionmentioning

confidence: 79%

Bone regeneration by bone morphogenetic protein-2 from porous beads with leaf-stacked structure for critical-sized femur defect model in dogs

Hong

Lee

et al. 2020

J Biomater Appl

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Physicochemical Properties of Olive Flounder Paralichthys olivaceus, Red Seabream Pagrus major and Jacopever Sebastes schlegeli

Yoon¹,

Lee²,

Kang³

et al. 2015

Journal of Fisheries and Marine Sciences Education

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Olive flounder (Paralichthys olivaceus) including red seabream (Pagrus major) and jacopever (Sebastes schlegeli) were known to be suitable characteristics for preparing a processed food because of white meat fish containing low fat in muscle. In this study, the physicochemical properties of olive flounder (46-50 cm of length, 950-1,050 g of weight), red seabream (30-33 cm of length, 1,250-1,350 g of weight) and jacopever (20-23 cm of length, 550-650 g of weight) were studied to obtain a basic data for the development of a new processed food. Head, scale, bone and viscera of each samples were removed, and then grinding with homogenizer before experiment. Moisture content of red seabream is lower than that of olive flounder and jacopever, therefore, crude protein and crude lipid are higher content. Red seabream showed higher redness, yellowess and color difference value than those of olive flounder and jacopever except lightness. The major total amino acid in olive flounder, seabream and jacopever were glutamic acid, lysine and aspartic acid in order. Especially, the highest content of free amino acid was lysine for olive flounder and jacopever and alanine for red seabream. The highest content of mineral in olive flounder, seabream and jacopever was potassium (K) and then phosphorous (P) and sodium (Na) in order. The highest amount of fatty acid in olive flounder, red seabream and jacopever was polyenoic acid in which especially contained 6.8, 7.1 and 6.7% for EPA, and 15.2, 15.2 and 17.1% for DHA, respectively. From the result of sensory evaluation, there was no significant difference in color and odor, but not in taste and texture.

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Composition of Collagen Extracted from the Skin of Three Different Varieties of Fish

Son

Shin

Park

et al. 2022

JKFN

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Many studies have been conducted on the methods of collagen extraction from fish skin. However, the specific composition of the collagen has not been reported so far. This study aimed to identify components other than amino acids in collagen. Collagen was extracted from the skin of tilapia (Oreochroma niloticus), flounder (Paralichthys olivaceus), and red sea bream (Pagrus major) using a commonly used acid extraction method. Thereafter, the component composition of collagen was confirmed. The yield of collagen was 1.11% from tilapia, 1.79% from red sea bream, and 2.06% from flounder. The protein content of all three samples, tilapia (85.39%), red sea bream (87.48%), and flounder (92.06%) collagen was over 85%. Analysis of the amino acid composition revealed that, glycine accounted for the highest proportion in all the samples of fish skin and collagen. The imino acid content was highest in the tilapia skin (151.1 residues) and collagen (210.7 residues). The triglyceride content in the of collagen was less than 0.7% in tilapia (0.37%), sea bream (0.61%), and flounder (0.31%). The major fatty acids in collagen were palmitic acid, stearic acid, and nervonic acid. Calcium in the fish skin accounted for the highest proportion of the mineral composition at 23.96∼466.84 mg/100 g, and the collagen contained a large amount of sodium 189.28∼1,433.52 mg/100 g. The collagen contained galactose, glucose, and mannose, and the galactose and glucose levels were three times higher than those of fish skin. Our study confirmed that the collagen extracted from fish skin contained lipids and minerals even though it was purified.

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Biomedical Materials for Regenerating Bone Tissue Utilizing Marine Invertebrate

Cited by 4 publications

References 98 publications

Bone regeneration by bone morphogenetic protein-2 from porous beads with leaf-stacked structure for critical-sized femur defect model in dogs

Bone regeneration by bone morphogenetic protein-2 from porous beads with leaf-stacked structure for critical-sized femur defect model in dogs

Physicochemical Properties of Olive Flounder Paralichthys olivaceus, Red Seabream Pagrus major and Jacopever Sebastes schlegeli

Composition of Collagen Extracted from the Skin of Three Different Varieties of Fish

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