-In this highly cornplex interdisciplinary area of biornedical polymers, progress is beginning to be nade in a variety of implants. Of probable major iinportance is that of S!I13.ll diameter blood vessel repair. The studies leading to the development of a S!I13.ll diameter vascular graft are discussed to show the interrelationship between polYJII7r surfac: and rulk ~hology, polymer-protein interaction, platelet adhes1.on, and llllplant mechan1.cal properties on the perfonnance of the implant in the body.A variety of polymeric implants have been tried for repair or replacement of darnaged or diseased tissues and organs. Initially these implants used polymeric rnaterials developed for other, non-biological applications. As a result, the implants, at best, worked in linuted situations, and at worst failed. During this last decade, we have seen a tremendous increase in research on the development of polymer rnaterials for biamedical applications. While some scientific progress has been nade, there has not been an accornpanying progr>ess in the clinical and surgical utilization of these biornedical inaterials. fuch of this has resulted from a lack of coupling between research in bicmediccil. rnaterials and the development studies related to the end-use applications. If we are to realize the potential in this area in which implant rnaterials are used to restore structure and function of the body, a variety of modified or new rna.terials, designed specifically for use in the body, are needed. However, this requires gaining an understanding of how polymer rnaterials and the biological system interact at the molecular level and the rnacroscopic (or implant) level.In this highly ccmplex interdisciplinary area, progr>ess is beginning to be rnade in a variety of implants. With the variety of excellent papers being presented in this section of the program, I will limit myself to discussing the development of a srnall diameter vascular gr>aft, and show the interrelationship between polymer surface and rulk rrorphology, polymer-protein interaction, implant mechanical properties, and polymer degr>adation on implant performance.The ultirnate goal of these studies is the development of satisfactory replacement rnaterials for damaged or obstructed veins or S!I13.ll diameter (less than 5 rrm) arteries. The need for such a prosthesis is not only in the area of peripheral vascular surgery where it is necessary for bypassing arterial obstruction, but also in aorta-coronary surgery where it is estimated 100,000 operations requiring srnall diarneter vessels will be perfarmed in 1977. Currently, the surgeon is forced to use autogenaus tissue such as the saphenous vein in these situations. This method has disadvantages in that satisfactory veins are not available in 10 to 25% of patients. Even in patients having satisfactory veins, one is limited in the size and quality available with removal of the veins requiring increased operating time. Therefore, the solving of this problern would be of significance to the surgeon and to the...