Biomedical Perspectives of Polyaniline Based Biosensors

Abstract

Electrically conducting polymers (ECPs) are finding applications in various fields of science owing to their fascinating characteristic properties such as binding molecules, tuning their properties, direct communication to produce a range of analytical signals and new analytical applications. Polyaniline (PANI) is one such ECP that has been extensively used and investigated over the last decade for direct electron transfer leading towards fabrication of mediator-less biosensors. In this review article, significant attention has been paid to the various polymerization techniques of polyaniline as a transducer material, and their use in enzymes/biomolecules immobilization methods to study their bio-catalytic properties as a biosensor for potential biomedical applications.

Conducting Polymers in the Fields of Energy, Environmental Remediation, and Chemical–Chiral Sensors

“…662 Biorecognition has been demonstrated incorporating oligonucleotides, enzymes, aptamer, or antigen/antibodies into specific polymers. 663 Undoubtedly, the main advantage presented by the biosensors is the specificity and very low detection limit, but there are many problems, such as durability, reproducibility, and the high costs of pure biomolecules employed in their construction, which makes it unusual to find the biosensors in the common market, and they are only available for very specific, but expensive, biochemical analysis. One exception is glucose biosensors, which are nowadays a commercially available product.…”

Bioactivation of Polyaniline for Biomedical Applications and Metal Oxide Composites

“…e efficiency of these devices was around 70% [8]. Hydrogels' properties have allowed them to be used in biomedical applications such as biosensors, drug delivery systems, contact lenses, catheters, and wound dressings [9]. One of the most popular applications is matrices for immobilizing and stabilizing enzymes [8,9].…”

Polyindole and polypyrrole as a sustainable platform for environmental remediation and sensor applications

“…Doping is the most used approach in electroanalysis due to reproducibility in the sensing of several targets. Unlike chemical sensors, a biosensor involves immobilization of biological recognition agents such as enzymes, oligonucleotides, aptamer, or antibodies/antigen into conducting polymers that recognize the presence of an analyte 264 . The Biorecognition technique can be categorized into five major classes based on the transducing mechanism: (i) optical-detection biosensors, (ii) resonant biosensors, (iii) thermal detection biosensors, (iv) electrochemical biosensors, and (v) ion-sensitive field-effect transistor-based biosensors 265 .…”