BIOMEDICAL POTENTIAL OF THE SPORE-RECOMBINANT STRAIN <i>BACILLUS SUBTILIS</i> 2335/105 IN THE COMPOSITION OF SUBALIN®, AS A LIVING THERAPEUTIC SYSTEM FOR THE DELIVERY OF ALPHA-INTERFERON IN VIRAL LEUKEMIA: ASSESSMENT OF THE EFFECT ON IMMUNE CELLS AND ORGANS OF MICE IN THE EXPERIMENT OF VIRAL LEUKEMIA

Abstract

<jats:p>To maintain a healthy immune system in animals, especially under conditions unfavorable for viral leukemia, a promising delivery system of biologically active molecules is considered – Subalin, a live delivery system. As a result of research, it has been established that with intraperitoneal and intravenous administration to animals, Subalin is harmless to animals, even at doses many times higher than the therapeutic one. With the introduction of the drug Subalin in animals stimulated humoral and cellular immunity, as evidenced by morphofunctional reorganization of the lymphoid system (spleen, lymph nodes). With the simultaneous administration of Subaline with a virus-containing suspension, subtility therapy had a stabilizing effect on the macroorganism, restraining the development of viral carcinogenesis.</jats:p>