Biomedicine Meets Fenton Chemistry

Abstract

Since the first connection between Fenton chemistry and biomedicine, numerous studies have been presented in this field. Comprehensive presentation of the guidance from Fenton chemistry and a summary of its representative applications in cancer therapy would help us understand and promote the further development of this field. This comprehensive review first supplies basic information regarding Fenton chemistry, including Fenton reactions and Fenton-like reactions. Subsequently, the current progress of Fenton chemistry is discussed, with some corresponding representative examples presented. Furthermore, the current strategies for further optimizing the performance of chemodynamic therapy guided by Fenton chemistry are highlighted. Most importantly, future perspectives on the combination of biomedicine with Fenton chemistry or a wider range of catalytic chemistry approaches are presented. We hope that this review will attract positive attention in the chemistry, materials science, and biomedicine fields and further tighten their connections.

Nanomedicines for combating multidrug resistance of cancer

“…Generally, Fenton reaction involves the reaction of ferrous ions (Fe 2+ ) with hydrogen peroxide (H 2 O 2 ), and then produces hydroxyl radicals (·OH) to destruct various cellular organelles, damage the DNA, and disrupt the vasculatures in tumor sites. Aside from Fe‐based NPs, nanocomposites based on several other metal elements such as Cu, Mn, Ag, and Co can also mediate Fenton‐like reactions to realize CDT (Tang et al, 2021). As H 2 O 2 , the substrate of CDT, is often present in tumor regions at higher levels than in normal tissues, CDT is considered as a highly specific therapeutic strategy with low systemic toxicity.…”

Design of ferrocenylseleno-dopamine derivatives to optimize the Fenton-like reaction efficiency and antitumor efficacy

“…It is well-established that the antitumoral activities of the ferrocene unit are activated mainly through the Fenton-like reaction with endogenous hydrogen peroxide in cancer cells to produce reactive cOH. 11,20,21 Therefore, the efficacy of cOH generation was measured to investigated the potential antitumor activity of ferrocene compound by adding F1-F4 to a mixture of H 2 O 2 and methylene blue (Table 2). In the studied compounds, F1 are inefficient compared to F2-F4 in cOH generation.…”

An All‐in‐One Organic Semiconductor for Targeted Photoxidation Catalysis in Hypoxic Tumor

“…Previous report showed that semiconductor could transfer electron from its conduction band to H 2 O 2 under irradiation, thus generating COH radicals. [21] If so,s ince H 2 O 2 is upregulated in hypoxic tumor, [22] the generated COH radicals in the decomposition of H 2 O 2 , which possess strong oxidation ability, [23] could cause huge oxidation damage to cancer cells.T he H 2 O 2 decomposition was assayed by DPD method. [24] However,a sobserved in Figure S11a-c )g eneration could be dictated by the interfacial electron transfer process (type Im echanisms) drove by photoexcitation.…”