Biomedizin in der Thoraxchirurgie: eine Standortbestimmung

Abstract

Biomedicine represents a new scientific field at the interface of human, molecular and cell biology and medicine. Comprising the diverse disciplines of stem cell research, tissue engineering and material sciences, biomedicine gives rise to new approaches in research and therapy for - to date - unmet medical issues. Biomedical research is currently conducted in many medical, especially surgical subspecialties, and a number of successful developments have already been brought to clinical application. Concerning thoracic surgery, biomedical approaches are pursued primarily for tissue and organ replacement of the upper airways, lung and thoracic wall. In spite of a comparatively small research foundation, five different concepts have been clinically implemented worldwide, due to a lack of established treatment options in the case of extensive disease of the greater airways. In this review, the clinical background and the tissue-specific basics of tracheobronchial biomedicine are presented.

Proliferation und Differenzierung von mesenchymalen Stromazellen auf biofunktionalisierten Copolymer-Trägern

“…Es vereint die positiven Eigenschaften der autologen Osteoinduktion, ohne dabei die Nachteile der operativ gewonnenen, autologen Transplantate nach sich zu ziehen (Holzapfel et al 2013). Um diese Geweberegeneration zu ermöglichen gibt es zellbasierte Therapien, gewebeinduzierende Faktoren und biokompatible Träger, die entweder einzeln oder in Kombination angewendet werden können (Holzapfel et al 2017;Leistner et al 2013).…”