BioMicroelectromechanical systems: A novel approach for drug targeting in chronic diseases

Shanbhag, Pradnya Palekar; Patil, Ninadha S.

doi:10.1016/j.nhtm.2017.01.001

Cited by 4 publications

(1 citation statement)

References 15 publications

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“…Based on their transducer type, biosensors can be classified as: (i) electrochemical; (ii) optical; or (iii) physical [ 120 ]. The acronym MEMS, originated in the USA, refers to Microsystems Technology in Europe and Micro Machines in Japan [ 121 ] and namely encompasses the micrometer-scaled (sized from several micrometers to several millimeters) precision devices which combine mechanical and electrical components to accomplish tasks that are normally performed by macroscopic systems [ 122 , 123 ] ( Figure 2 ). MEMS are micromachining techniques in the integrated circuit industry; the main material for their manufacture is silicon [ 124 ].…”

Section: Impact Of Micro-technologies In Cancer Medicinementioning

confidence: 99%

Smart Sensors and Microtechnologies in the Precision Medicine Approach against Lung Cancer

et al. 2023

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Background and rationale. The therapeutic interventions against lung cancer are currently based on a fully personalized approach to the disease with considerable improvement of patients’ outcome. Alongside continuous scientific progresses and research investments, massive technologic efforts, innovative challenges, and consolidated achievements together with research investments are at the bases of the engineering and manufacturing revolution that allows a significant gain in clinical setting. Aim and methods. The scope of this review is thus to focus, rather than on the biologic traits, on the analysis of the precision sensors and novel generation materials, as semiconductors, which are below the clinical development of personalized diagnosis and treatment. In this perspective, a careful revision and analysis of the state of the art of the literature and experimental knowledge is presented. Results. Novel materials are being used in the development of personalized diagnosis and treatment for lung cancer. Among them, semiconductors are used to analyze volatile cancer compounds and allow early disease diagnosis. Moreover, they can be used to generate MEMS which have found an application in advanced imaging techniques as well as in drug delivery devices. Conclusions. Overall, these issues represent critical issues only partially known and generally underestimated by the clinical community. These novel micro-technology-based biosensing devices, based on the use of molecules at atomic concentrations, are crucial for clinical innovation since they have allowed the recent significant advances in cancer biology deciphering as well as in disease detection and therapy. There is an urgent need to create a stronger dialogue between technologists, basic researchers, and clinicians to address all scientific and manufacturing efforts towards a real improvement in patients’ outcome. Here, great attention is focused on their application against lung cancer, from their exploitations in translational research to their application in diagnosis and treatment development, to ensure early diagnosis and better clinical outcomes.

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Section: Impact Of Micro-technologies In Cancer Medicinementioning

confidence: 99%

Smart Sensors and Microtechnologies in the Precision Medicine Approach against Lung Cancer

et al. 2023

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Sensing the Future─Frontiers in Biosensors: Exploring Classifications, Principles, and Recent Advances

Manoharan Nair Sudha Kumari,

Thankappan Suryabai

2024

ACS Omega

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Biosensors are transforming healthcare by delivering swift, precise, and economical diagnostic solutions. These analytical instruments combine biological indicators with physical transducers to identify and quantify biomarkers, thereby improving illness detection, management, and patient surveillance. Biosensors are widely utilized in healthcare for the diagnosis of chronic and infectious diseases, tailored treatment, and real-time health monitoring. This thorough overview examines several categories of biosensors and their uses in the detection of numerous biomarkers, including glucose, proteins, nucleic acids, and infections. Biosensors are commonly classified based on the type of transducer employed or the specific biorecognition element utilized. This review introduces a novel classification based on substrate morphology, offering a comprehensive perspective on biosensor categorization. Considerable emphasis is placed on the advancement of point-of-care biosensors, facilitating decentralized diagnostics and alleviating the strain on centralized healthcare systems. Recent advancements in nanotechnology have significantly improved the sensitivity, selectivity, and downsizing of biosensors, rendering them more efficient and accessible. The study examines problems such as stability, reproducibility, and regulatory approval that must be addressed to enable the widespread implementation of biosensors in clinical environments. The study examines the amalgamation of biosensors with wearable devices and smartphones, emphasizing the prospects for ongoing health surveillance and individualized medical care. This viewpoint clarifies the distinct types of biosensors and their particular roles, together with recent developments in the "smart biosensor" sector, facilitated by artificial intelligence and the Internet of Medical Things (IoMT). This novel approach seeks to deliver a comprehensive evaluation of the present condition of biosensor technology in healthcare, recent developments, and prospective paths, emphasizing their significance in influencing the future of medical diagnostics and patient care.

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Microelectromechanical Systems (MEMS) for Biomedical Applications

Chircov

Grumezescu

2022

Micromachines

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The significant advancements within the electronics miniaturization field have shifted the scientific interest towards a new class of precision devices, namely microelectromechanical systems (MEMS). Specifically, MEMS refers to microscaled precision devices generally produced through micromachining techniques that combine mechanical and electrical components for fulfilling tasks normally carried out by macroscopic systems. Although their presence is found throughout all the aspects of daily life, recent years have witnessed countless research works involving the application of MEMS within the biomedical field, especially in drug synthesis and delivery, microsurgery, microtherapy, diagnostics and prevention, artificial organs, genome synthesis and sequencing, and cell manipulation and characterization. Their tremendous potential resides in the advantages offered by their reduced size, including ease of integration, lightweight, low power consumption, high resonance frequency, the possibility of integration with electrical or electronic circuits, reduced fabrication costs due to high mass production, and high accuracy, sensitivity, and throughput. In this context, this paper aims to provide an overview of MEMS technology by describing the main materials and fabrication techniques for manufacturing purposes and their most common biomedical applications, which have evolved in the past years.

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BioMicroelectromechanical systems: A novel approach for drug targeting in chronic diseases

Cited by 4 publications

References 15 publications

Smart Sensors and Microtechnologies in the Precision Medicine Approach against Lung Cancer

Smart Sensors and Microtechnologies in the Precision Medicine Approach against Lung Cancer

Sensing the Future─Frontiers in Biosensors: Exploring Classifications, Principles, and Recent Advances

Microelectromechanical Systems (MEMS) for Biomedical Applications

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