Biomimetic CoO@AuPt nanozyme responsive to multiple tumor microenvironmental clues for augmenting chemodynamic therapy

Fu, Shiyan; Yang, Ruihao; Zhang, Lei; Liu, Weiwei; Du, Guangyuan; Cao, Yang; Xu, Zhigang; Cui, Hongjuan; Kang, Yuejun; Xue, Peng

doi:10.1016/j.biomaterials.2020.120279

Cited by 121 publications

(71 citation statements)

References 61 publications

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“…GSSH Glutathione disulfide, EPR enhanced permeation and retention, MW microwave, MRI magnetic resonance imaging, MTT microwave thermal therapy, FI fluorescence imaging. Adapted from a Ref [426],. b Ref [131].…”

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confidence: 99%

A Review on Metal- and Metal Oxide-Based Nanozymes: Properties, Mechanisms, and Applications

et al. 2021

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Since the ferromagnetic (Fe3O4) nanoparticles were firstly reported to exert enzyme-like activity in 2007, extensive research progress in nanozymes has been made with deep investigation of diverse nanozymes and rapid development of related nanotechnologies. As promising alternatives for natural enzymes, nanozymes have broadened the way toward clinical medicine, food safety, environmental monitoring, and chemical production. The past decade has witnessed the rapid development of metal- and metal oxide-based nanozymes owing to their remarkable physicochemical properties in parallel with low cost, high stability, and easy storage. It is widely known that the deep study of catalytic activities and mechanism sheds significant influence on the applications of nanozymes. This review digs into the characteristics and intrinsic properties of metal- and metal oxide-based nanozymes, especially emphasizing their catalytic mechanism and recent applications in biological analysis, relieving inflammation, antibacterial, and cancer therapy. We also conclude the present challenges and provide insights into the future research of nanozymes constituted of metal and metal oxide nanomaterials.

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confidence: 99%

A Review on Metal- and Metal Oxide-Based Nanozymes: Properties, Mechanisms, and Applications

et al. 2021

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“…This fluorescent emission peak corresponds to 2‐hydroxy terephthalic acid (TAOH) which is the oxidation product of TA by the hydroxyl radical. [ 54,55 ] In the meanwhile, we have tested the formation of the hydroxyl radical at different concentrations of hydrogen peroxide by using TA as a fluorescent probe. The results showed that with an increase in the hydrogen peroxide concentration, the corresponding fluorescence intensity increased, which also indicated the formation of •OH (Figure S11, Supporting Information).…”

Section: Resultsmentioning

confidence: 99%

Multienzyme‐Mimic Ultrafine Alloyed Nanoparticles in Metal Organic Frameworks for Enhanced Chemodynamic Therapy

Yang

Tao

Chen

et al. 2021

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Nanozyme‐based chemodynamic therapy (CDT) has emerged as an effective cancer treatment because of its low side effects and without the requirement of exogenous energy. The therapeutic effect of CDT highlights the pivotal importance of active sites, H2O2 supplement and the glutathione (GSH) depletion of a nanozyme. The construction of a single kind of catalyst with multiple functions for the enhanced CDT is still a big challenge. In this work, seven types of bimetallic nanoparticles are synthesized using a metal–organic framework (MOF) as a stable host instead of a Fenton or Fenton‐like ions supplier. Among them, Cu‐Pd@MIL‐101 with an alloy loading of 9.5 wt% modified by PEG (9.5% CPMP) is found to exhibit the highest peroxidase (POD) like activity combined with a superoxide dismutase (SOD) mimic activity and the function of GSH depletion. The in vivo results suggest that the stable and ultrafine nanoparticles possess favorable CDT effect for tumor and good biosafety as well as biocompatibility. This work has provided a credible strategy to construct nanozymes with an excellent activity and may pave a new way for the design of enhanced tumor CDT treatment.

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“…Based on the lower pH value of tumor than normal tissues, many kinds of pH‐sensitive drug release systems have been cultivated for responding to the acidity of tumor [5b, 12] . Moreover, current CDT systems usually rely significantly on the acidic conditions (pH 3.0–5.0), while the pH value (6.5–6.9) in tumor was usually not able to sustain the persistent drug release from carries and satisfactory Fenton reaction efficiency due to the gradual consumption of acidity [1c, 31] . When the acidity of tumor was gradually consumed, the release amount of drug and CDT efficacy was significantly suppressed for cancer therapy.…”

Section: Discussionmentioning

confidence: 99%

An Acidity‐Unlocked Magnetic Nanoplatform Enables Self‐Boosting ROS Generation through Upregulation of Lactate for Imaging‐Guided Highly Specific Chemodynamic Therapy

et al. 2021

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Chemodynamic therapy is an emerging tumor therapeutic strategy. However, the anticancer effects are greatly limited by the strong acidity requirements for effective Fenton‐like reaction, and the inevitably “off‐target” toxicity. Herein, we develop an acidity‐unlocked nanoplatform (FePt@FeOx@TAM‐PEG) that can accurately perform the high‐efficient and tumor‐specific catalysis for anticancer treatment, through dual pathway of cyclic amplification strategy. Notably, the pH‐responsive peculiarity of tamoxifen (TAM) drug allows for the catalytic activity of FePt@FeOx to be “turn‐on” in acidic tumor microenvironments, while keeping silence in neutral condition. Importantly, the released TAM within cancer cells is able to inhibit mitochondrial complex I, leading to the upregulated lactate content and thereby the accumulated intracellular H+, which can overcome the intrinsically insufficient acidity of tumor. Through the positive feedback loop, large amount of active FePt@FeOx nanocatalyzers are released and able to access to the endogenous H2O2, exerting the improved Fenton‐like reaction within the more acidic condition. Finally, such smart nanoplatform enables self‐boosting generation of reactive oxygen species (ROS) and induces strong intracellular oxidative stress, leading to the substantial anticancer outcomes in vivo, which may provide a new insight for tumor‐specific cascade catalytic therapy and reducing the “off‐target” toxicity to surrounding normal tissues.

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Biomimetic CoO@AuPt nanozyme responsive to multiple tumor microenvironmental clues for augmenting chemodynamic therapy

Cited by 121 publications

References 61 publications

A Review on Metal- and Metal Oxide-Based Nanozymes: Properties, Mechanisms, and Applications

A Review on Metal- and Metal Oxide-Based Nanozymes: Properties, Mechanisms, and Applications

Multienzyme‐Mimic Ultrafine Alloyed Nanoparticles in Metal Organic Frameworks for Enhanced Chemodynamic Therapy

An Acidity‐Unlocked Magnetic Nanoplatform Enables Self‐Boosting ROS Generation through Upregulation of Lactate for Imaging‐Guided Highly Specific Chemodynamic Therapy

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