Biomimetic Creation of Surfaces on Porous Titanium for Biomedical Applications

Mediaswanti, Kun; Wen, Cuié; Ivanova, Elena P.; Malherbe, François; Berndt, C. C.; Pham, Vy; Wang, James

doi:10.4028/www.scientific.net/amr.896.259

Cited by 8 publications

(7 citation statements)

References 8 publications

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“…First, most metals possess much higher elastic modulus than bone that could lead to stress shielding. Thus, it is necessary to construct scaffolds with porous metals to reduce the chance of stress shielding as well as to increase the possibility of vascularization in the scaffold . Second, due to the lack of integration with host tissues, metallic scaffolds generally could not integrate biomolecules around.…”

Section: Traditional Scaffolds For Bone Tissue Engineeringmentioning

confidence: 99%

Bone Tissue Engineering via Carbon‐Based Nanomaterials

Peng

Zhao

Zhou

et al. 2020

Adv Healthcare Materials

142

106

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Bone tissue engineering (BTE) has received significant attention due to its enormous potential in treating critical‐sized bone defects and related diseases. Traditional materials such as metals, ceramics, and polymers have been widely applied as BTE scaffolds; however, their clinical applications have been rather limited due to various considerations. Recently, carbon‐based nanomaterials attract significant interests for their applications as BTE scaffolds due to their superior properties, including excellent mechanical strength, large surface area, tunable surface functionalities, high biocompatibility as well as abundant and inexpensive nature. In this article, recent studies and advancements on the use of carbon‐based nanomaterials with different dimensions such as graphene and its derivatives, carbon nanotubes, and carbon dots, for BTE are reviewed. Current challenges of carbon‐based nanomaterials for BTE and future trends in BTE scaffolds development are also highlighted and discussed.

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Section: Traditional Scaffolds For Bone Tissue Engineeringmentioning

confidence: 99%

Bone Tissue Engineering via Carbon‐Based Nanomaterials

Peng

Zhao

Zhou

et al. 2020

Adv Healthcare Materials

142

106

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“…[9] However, these materials may present several disadvantages, as in selected cases they exhibit insufficient osseointegration capacity and adverse reaction of the host tissues to the release of metallic ions. [15] Titanium has been in common use in orthopedics since the 1940s due to its unique, medically applicable properties such as high specific strength, low weight, and corrosion resistance, contributing to its biocompatibility. In consequence, leading to fibrous tissue ingrowth at implant interface, osseointegration disruption, implant mobility, and the development of an inflammatory response that leads to the necessity for revision surgery.…”

Section: Introductionmentioning

confidence: 99%

Porous Titanium Implants: A Review

2018

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Titanium and its alloys are commonly used in almost all disciplines of medicine because of their sufficient biocompatibility and meeting of mechanical requirements. However, dense metallic biomaterials represent only an interfacial connection with host tissue, may develop stress shielding which causes ingrowth of the fibrous tissue, and are prone to microbial adhesion and development of biomaterial associated infections. Therefore, development of a new, porous titanium biomaterial is proposed to improve an implant's interconnection with bone, provide better stabilization, and reduce the risk of the loss of the implant. In this review, recent findings in porous titanium biomaterials engineering are discussed, including the structural and strengthening aspects of titanium alloys. The porosity and design of porous structures, as well as the optimization process are also described. An extensive part of this section is dedicated to manufacturing processes. The next section of the review is devoted to osseointegration of porous implants and surface treatment processes, whose purpose are antibacterial activity or local drug delivery. Summarizing the article, some future predictions have been presented.

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“…An ideal bone scaffold should possess similar composition and architecture to human native bone. As such there are five essential characteristics to be fulfilled: (1) materials used and by-products should be non-toxic [1], (2) osteoconductive and osteoinductive by itself [2], [3], (3) resorbable/ degradable over time as new bone tissue forms [4], (4) interconnected pores with porosity (70-90%) and pore size (~200-500 μm) [5] and (5) sufficient mechanical strength to allow ease of handling [6].…”

Section: Introductionmentioning

confidence: 99%

“…Among various bioceramic materials, carbonated hydroxyapatite (CHA) ceramic has received considerable attention as scaffold material owing to its composition, which is more akin to the inorganic mineralized phase of human bone as compared to pure hydroxyapatite (HA). The amount of carbonate (CO3 2-) found in bone mineral is about 2-8 wt% [3], [7]. It is well documented that CO3 2plays an essential role in enhancing bone metabolic activity [8].…”

Section: Introductionmentioning

confidence: 99%

Influence of ternary divalent cations (Mg2+, Co2+, Sr2+) substitution on the physicochemical, mechanical and biological properties of carbonated hydroxyapatite scaffolds

B.I.

M.N.

et al. 2021

J Aust Ceram Soc

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Substitution of ionic either anion or cation in a controlled amount into carbonated hydroxyapatite (CHA) structure is one of the efficient and safest ways in enhancing the properties of the materials. However, most of the works studied only focused on the physical and mechanical properties of single ionic substitution. For the first time, the influence of simultaneous ternary substitutions of divalent cations into porous CHA scaffolds on the physicochemical, mechanical, degradation and in vitro biological properties are investigated in the present study. Three different compositions of porous scaffolds with binary and ternary divalent cations, namely, pure CHA (S11), CoSr CHA (S21) and MgCoSr CHA (S31) were fabricated using polyurethane (PU) foam replication technique. Despite a small amount of Mg 2+ , Co 2+ and Sr 2+ added, these divalent cations had successfully substituted into the Ca 2+ site and remained as single phase B-type CHA. The produced scaffolds demonstrated open, interconnected and uniform pores. Interestingly, simultaneous ternary divalent cations substitution into CHA structure had successfully enhanced the compressive strength of the sintered scaffolds, also promoted better cell attachment and activities than the binary dopedand pure CHA scaffolds. It is important to note that the right choice of divalent cation can be the determining factor in tuning the physicochemical, mechanical and biological properties of CHA scaffolds.

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Biomimetic Creation of Surfaces on Porous Titanium for Biomedical Applications

Cited by 8 publications

References 8 publications

Bone Tissue Engineering via Carbon‐Based Nanomaterials

Bone Tissue Engineering via Carbon‐Based Nanomaterials

Porous Titanium Implants: A Review

Influence of ternary divalent cations (Mg2+, Co2+, Sr2+) substitution on the physicochemical, mechanical and biological properties of carbonated hydroxyapatite scaffolds

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