Biomimetic hydrogel for rapid and scar-free healing of skin wounds inspired by the healing process of oral mucosa

Kong, Xiaoying; Fu, Jun; Shao, Kai; Wang, Lili; Lan, Xuefang; Shi, Jinsheng

doi:10.1016/j.actbio.2019.10.011

Cited by 73 publications

(46 citation statements)

References 39 publications

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“…Growth factor therapies have the potential to overcome the shortcomings of current wound care problems 42 . Growth factors are critical factors that orchestrate the wound healing process 43 . During wound healing, interactions between ECM and surrounding cell-signaling molecules lead to the expression of growth factors and cytokines which ultimately lead to the formation of new tissues.…”

Section: Discussionmentioning

confidence: 99%

PEG grafted chitosan scaffold for dual growth factor delivery for enhanced wound healing

Vijayan

Sabareeswaran

Kumar

2019

Sci Rep

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Application of growth factors at wound site has improved the efficiency and quality of healing. Basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) induce proliferation of various cells in wound healing. Delivery of growth factor from controlled release systems protect it from degradation and also result in sustained delivery of it at the site of injury. The goal of the study was to develop a Polyethylene glycol (PEG) cross-linked cotton-like chitosan scaffold (CS-PEG-H) by freeze-drying method and chemically conjugate heparin to the scaffold to which the growth factors can be electrostatically bound and evaluate its wound healing properties in vitro and in vivo. The growth factor containing scaffolds induced increased proliferation of HaCaT cells, increased neovascularization and collagen formation seen by H and E and Masson’s trichrome staining. Immunohistochemistry was performed using the Ki67 marker which increased proliferation of cells in growth factor containing scaffold treated group. Frequent dressing changes are a major deterrent to proper wound healing. Our system was found to release both VEGF and bFGF in a continuous manner and attained stability after 7 days. Thus our system can maintain therapeutic levels of growth factor at the wound bed thereby avoiding the need for daily applications and frequent dressing changes. Thus, it can be a promising candidate for wound healing.

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Section: Discussionmentioning

confidence: 99%

PEG grafted chitosan scaffold for dual growth factor delivery for enhanced wound healing

Vijayan

Sabareeswaran

Kumar

2019

Sci Rep

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“…The samples were accurately weighed and subsequently dehydrated in a hot-oven for 5 h. The dehydrated fabrics of cotton were desiccated for 24 h to remove moisture and weighed again. The moisture contents of the PMN/GLY and LCH@PMN/GLY were calculated using a previously reported protocol [41][42][43][44].…”

Section: Synthesis Of Pmn/gly and Lch@pmn/gly Nanocomposites For Bandagingmentioning

confidence: 99%

In Vivo Observation of Lidocaine-Encapsulated Polymyxin/Glycol Nanoparticles Wound Dressing for the Treatment and Care of Abdominal Pain Incision in Intensive Care Unit

et al. 2021

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The developments of lidocaine chloride loaded nanoparticles are encouraging biomaterials, which could be used for wound healing applications for abdominal pain management. The current work presents the composition of wound dressings based on lidocaine chloride (LCH) (anesthetic drug)-loaded Polymyxin (PMN)/Glycol (GLY). The LCH nanocomposite (LCH@PMN/GLY) were fabricated by the LCH oxide solutions within the PMN/GLY matrix. The in uences of different experimental limitations on PMN/GLY nanoparticles formations were examined. The PMN/GLY and LCH@PMN/GLY nanoparticle sizes were evaluated by high resolution-scanning electron microscopy (HR-SEM). Additionally, the antibacterial e cacy of PMN/GLY and LCH@PMN/GLY was developed for gram-positive and negative microorganisms. Moreover, we examined in vivo healing of skin wounds formed in mouse models over 20 days. In contrast to the untreated wounds, rapid healing was perceived in the LCH@PMN/GLY-treated wound with less damage. These ndings indicate that LCH@PMN/GLY-based bandaging materials could be a potential innovative biomaterial for tissue repair and implantation and nursing care for wound healing applications for abdominal pain incision in intensive care unit (ICU) management in an animal model.

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“…Almost all wounds are polluted by bacteria to varying degrees from the air or tissues near the wounds. How to effectively provide a sterile environment for wounds has always been a problem worth exploring in the field of wound dressing research [1,2]. Traditional wound dressings are mainly made of cotton and yarn; the material s lack of antibacterial activity requires the need for it to be replaced frequently to keep the wound clean, which may cause secondary injury to the wound [3,4].…”

Section: Introductionmentioning

confidence: 99%

Preparation of Electrospun Gelatin Mat with Incorporated Zinc Oxide/Graphene Oxide and Its Antibacterial Activity

Chen

et al. 2020

Molecules

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Current wound dressings have poor antimicrobial activities and are difficult to degrade. Therefore, biodegradable and antibacterial dressings are urgently needed. In this article, we used the hydrothermal method and side-by-side electrospinning technology to prepare a gelatin mat with incorporated zinc oxide/graphene oxide (ZnO/GO) nanocomposites. The resultant fibers were characterized by field emission environment scanning electron microscopy (FESEM), energy-dispersive X-ray spectroscopy (EDX), X-ray diffractometry (XRD) and Fourier transform infrared spectroscopy (FTIR). Results indicated that the gelatin fibers had good morphology, and ZnO/GO nanocomposites were uniformly dispersed on the fibers. The loss of Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) viability were observed to more than 90% with the incorporation of ZnO/GO. The degradation process showed that the composite fibers completely degraded within 7 days and had good controllable degradation characteristics. This study demonstrated the potential applicability of ZnO/GO-gelatin mats with excellent antibacterial properties as wound dressing material.

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Biomimetic hydrogel for rapid and scar-free healing of skin wounds inspired by the healing process of oral mucosa

Cited by 73 publications

References 39 publications

PEG grafted chitosan scaffold for dual growth factor delivery for enhanced wound healing

PEG grafted chitosan scaffold for dual growth factor delivery for enhanced wound healing

In Vivo Observation of Lidocaine-Encapsulated Polymyxin/Glycol Nanoparticles Wound Dressing for the Treatment and Care of Abdominal Pain Incision in Intensive Care Unit

Preparation of Electrospun Gelatin Mat with Incorporated Zinc Oxide/Graphene Oxide and Its Antibacterial Activity

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