Biomimetic materials in tissue engineering

Patterson, Jennifer; Martino, Mikaël M.; Hubbell, Jeffrey A.

doi:10.1016/s1369-7021(10)70013-4

Cited by 271 publications

(185 citation statements)

References 95 publications

Supporting

Mentioning

184

Contrasting

Unclassified

Order By: Relevance

“…In spite of the potential variability in composition of natural biomaterials, protein derived scaffold materials, such as collagen, fibrin and glycosaminoglycan (Patterson et al 2010) often possess the chemical structures that can mimic native tissue, thereby aiding biocompatibility (Agrawal et al 2014a, b, c). For example, collagen type I (a key component of the ECM), can be reconstructed into a fibrillar matrix beneficial for cell attachment and has been formed into hydrogel sponges used for bone and tissue repair (Glowacki and Mizuno 2008).…”

Section: Introductionmentioning

confidence: 99%

Surface modified cellulose scaffolds for tissue engineering

et al. 2016

View full text Add to dashboard Cite

We report the ability of cellulose to support cells without the use of matrix ligands on the surface of the material, thus creating a two-component system for tissue engineering of cells and materials. Sheets of bacterial cellulose, grown from a culture medium containing Acetobacter organism were chemically modified with glycidyltrimethylammonium chloride or by oxidation with sodium hypochlorite in the presence of sodium bromide and 2,2,6,6-tetramethylpipiridine 1-oxyl radical to introduce a positive, or negative, charge, respectively. This modification process did not degrade the mechanical properties of the bulk material, but grafting of a positively charged moiety to the cellulose surface (cationic cellulose) increased cell attachment by 70% compared to unmodified cellulose, while negatively charged, oxidised cellulose films (anionic cellulose), showed low levels of cell attachment comparable to those seen for unmodified cellulose. Only a minimal level of cationic surface derivitisation (ca 3% degree of substitution) was required for increased cell attachment and no mediating proteins were required. Cell adhesion studies exhibited the same trends as the attachment studies, while the mean cell area and aspect ratio was highest on the cationic surfaces. Overall, we demonstrated the utility of positively charged bacterial cellulose in tissue engineering in the absence of proteins for cell attachment.

show abstract

Section: Introductionmentioning

confidence: 99%

Surface modified cellulose scaffolds for tissue engineering

et al. 2016

View full text Add to dashboard Cite

show abstract

“…The reason for this is that bone does not only function in a structural role, but is also a site for muscle anchoring and bone marrow production while playing a significant role in mineral homeostasis [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

In vitro osteoclast-like and osteoblast cells’ response to electrospun calcium phosphate biphasic candidate scaffolds for bone tissue engineering

Wepener

Richter

Papendorp

et al. 2012

J Mater Sci: Mater Med

View full text Add to dashboard Cite

Successful long term bone replacement and repair remain a challenge today. Nanotechnology has makes it possible to alter materials' characteristics and therefore possibly improve on the material itself. In this study, biphasic (hydroxyapatite/β-tricalcium phosphate (HA/β-TCP)) nanobioceramic scaffolds were prepared by the electrospinning technique in order to mimic the extracellular matrix (ECM). Scaffolds were characterised by scanning electron microscopy (SEM) and Attentuated Total Reflectance Fourier Transform Infrared (ATR-FTIR). Osteoblasts as well as monocytes that were differentiated into osteoclast-like cells, were cultured separately on the biphasic bioceramic scaffolds for up to 6 days and the proliferation, adhesion and cellular response were determined using lactate dehydrogenase (LDH) cytotoxicity assay, nucleus and cytoskeleton dynamics, analysis of the cell cycle progression, measurement of the mitochondrial membrane potential and the detection of phosphatidylserine expression. SEM analysis of the biphasic bioceramic scaffolds revealed n ano fi be rs spun i n a m e sh -like sc af fold . Re sul ts indi c ate th at th e bi ph asi c bio ce ram ic electrospun scaffolds are biocompatible and have no significant negative effects on either osteoblasts or osteoclast-like cells in vitro.

show abstract

“…Yosuke Amagai 1 , Kaoru Karasawa 1,2 , Jung Kyungsook 2 , Akira Matsuda 3 , Masanori Kojima 4 , Jun Watanabe 4 , Toyoji Hibi 5 , Hiroshi Matsuda 1,3 , and Akane Tanaka 1,2, * 1 Cooperative Major in Advanced Health Science; Graduate School of Bio-Applications and System Engineering; Laboratories of; 2 Comparative Animal Medicine and; 3 Veterinary Molecular Pathology and Therapeutics; Division of Animal Life Science; Tokyo University of Agriculture and Technology; Tokyo, Japan; 4 Nikkan Industries Co.; Ltd.; Tokyo, Japan; 5 Sakado plant; Tokyo, Japan T issue engineering is a rapidly advancing technology in the field of regenerative medicine. For the transplantation of cell sheets, a carrier must maintain the shape of a cell sheet from a culture dish to affected sites as well as release the sheet easily onto the lesion.…”

Section: Development Of a Novel Carrier Optimized For Cell Sheet Tranmentioning

confidence: 99%

“…1 Applications for cell sheet technology have been actively investigated in this field, as represented by preclinical or clinical studies of cell sheets derived from corneal cells, myocardial cells, and keratinocytes. [2][3][4][5][6] For the transplantation of cell sheets from a culture dish to the affected site, a carrier that can maintain its morphology without any shrinkage is necessary.…”

Section: Development Of a Novel Carrier Optimized For Cell Sheet Tranmentioning

confidence: 99%