Biomimetic nanoengineered scaffold for enhanced full-thickness cutaneous wound healing

Zandi, Nooshin; Dolatyar, Banafsheh; Lotfi, Reza; Shallageh, Yousef; Shokrgozar, Mohammad Ali; Tamjid, Elnaz; Annabi, Nasim; Simchi, A.

doi:10.1016/j.actbio.2021.01.029

Cited by 95 publications

(52 citation statements)

References 83 publications

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“…Good biocompatibility is an important factor in tissue engineered scaffold [ 39 ]. In order to further evaluate the cytocompatibility of these samples, the samples were tested for cytotoxicity.…”

Section: Resultsmentioning

confidence: 99%

Polyvinyl Alcohol/Chitosan and Polyvinyl Alcohol/Ag@MOF Bilayer Hydrogel for Tissue Engineering Applications

et al. 2021

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In this paper, polyvinyl alcohol/Ag-Metal-organic framework (PVA/Ag@MOF) and polyvinyl alcohol/chitosan (PVA/CS) were used as the inner and outer layers to successfully prepare a bilayer composite hydrogel for tissue engineering scaffold. The performance of bilayer hydrogels was evaluated. The outer layer (PVA/CS) has a uniform pore size distribution, good water retention, biocompatibility and cell adhesion ability. The inner layer (PVA/Ag@MOF) has good antibacterial activity and poor biocompatibility. PVA, PVA/0.1%Ag@MOF, PVA/0.5%Ag@MOF, and PVA/1.0%Ag@MOF show anti-microbial activity in ascending order. However, its use as an inner layer avoids direct contact with cells and prevents infection. The cell viability of all samples was above 90%, indicating that the bilayer hydrogel was non-toxic to A549 cells. The bilayer hydrogel scaffold combines the advantages of the inner and outer layers. In summary, this new bilayer composite is an ideal lung scaffold for tissue engineering.

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Section: Resultsmentioning

confidence: 99%

Polyvinyl Alcohol/Chitosan and Polyvinyl Alcohol/Ag@MOF Bilayer Hydrogel for Tissue Engineering Applications

et al. 2021

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“…Improving mechanical properties In situ polymerization [59], electrospinning technology [60], casting and coordination interaction [61][62][63][64] Drug release Three-tier structure [65] and embedding [66] Cross-linked and direct interaction [26,49,58,[67][68][69][70] Antibacterial effect [39] Interfering with DNA replication and RNA production Destroy cell membranes Interference with cellular respiration Change enzyme conformation and inactivate enzyme activity Increased adhesion…”

Section: Effective Mechanismmentioning

confidence: 99%

“…Collagen-based hydrogel Forms microenvironment similar to extracellular mechanisms Spontaneous migration of fibroblasts [73], antibacterial [26,58,67], and improve mechanical properties [61] Gelatin-based hydrogel Good biocompatibility, solubility Improved mechanical properties [59], adhesion [71], antibacterial [68], drug release [65], and regeneration [71] Fibrin-based hydrogel Good adhesion, biocompatibility Increase mechanical strength [62,63] and regeneration [62] Chitosan-based hydrogel Good hemostatic properties Increase mechanical strength [72], adhesion [60], antibacterial [74], and drug release [66] Cellulose-based hydrogel Most distributed, content Increase the scope of application [75], antibacterial [69,75], drug release [69], and regeneration [49] Hyaluronic acid-based hydrogel Good hydrophilicity, biocompatibility Increase mechanical strength [64] and regeneration [76] Polyethylene glycol-based hydrogel High molecular polymer Promote cell proliferation [77], antibacterial [77], and drug release [70] Journal of Nanomaterials release of epidermal growth factor (EGF) and the ability to stop bleeding to stimulate complete skin regeneration [66]. Lin produced a multifunctional three-layer wound dressing (sandwich dressing).…”

Section: Type Advantage Applicationmentioning

confidence: 99%

Application of Nanomaterial in Hydrogels Related to Wound Healing

Liu

Song

Liu

et al. 2022

Journal of Nanomaterials

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Traditional dressings used for wound repair, such as gauze, have shortcomings; for example, they cannot provide a suitable microenvironment for wound recovery. Therefore, it is necessary to find a better dressing to overcome shortcomings. Hydrogel provides a suitable wet environment, has good biocompatibility, and has a strong swelling rate to absorb exudate. Nanomaterial in hydrogels has been used to improve their performance and overcome the shortcomings of current hydrogel dressings. Hydrogel dressing can also be loaded with nanodrug particles to exert a better therapeutic effect than conventional drugs and to make the dressing more practical. This article reviews the application of nanotechnology in hydrogels related to wound healing and discusses the application prospects of nanohydrogels. After searching for hydrogel articles related to wound healing, we found that nanomaterial can not only enhance the mechanical strength, antibacterial properties, and adhesion of hydrogels but also achieve sustained drug release. From the perspective of clinical application, these characteristics are significant for wound healing. The combination of nanomaterial and hydrogel is an ideal dressing with broad application prospects for wound healing in the future.

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“…However, multiple factors can cause serious skin injuries, leading to wound infection, uncontrolled bleeding, and serious complications [1][2][3]. Thus, the development of novel wound dressings with multifunctional properties, including hemostasis, low-hemolysis, long-term antibacterial activity, and wound healing, is vitally important [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Bioinspired Design of Sericin/Chitosan/Ag@MOF/GO Hydrogels for Efficiently Combating Resistant Bacteria, Rapid Hemostasis, and Wound Healing

Zhang

Wang

et al. 2021

Polymers

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Due to the spread of drug-resistant bacteria in hospitals, the development of antibacterial dressings has become a strategy to control wound infections caused by bacteria. Here, we reported a green strategy for in situ biomimetic syntheses of silver nanoparticles@organic frameworks/graphene oxide (Ag@MOF–GO) in sericin/chitosan/polyvinyl alcohol hydrogel. Ag@MOF–GO was synthesized in situ from the redox properties of tyrosine residues in silk sericin without additional chemicals, similar to a biomineralization process. The sericin/chitosan/Ag@MOF–GO dressing possessed a high porosity, good water retention, and a swelling ratio. The hemolysis rate of the composite was 3.9% and the cell viability rate was 131.2%, which indicated the hydrogel possessed good biocompatibility. The composite also showed excellent lasting antibacterial properties against drug-sensitive and drug-resistant pathogenic bacteria. The composite possessed excellent hemostatic activity. The coagulation effect of the composite may be related to its effect on the red blood cells and platelets, but it has nothing to do with the activation of coagulation factors. An in vitro cell migration assay confirmed and an in vivo evaluation of mice indicated that the composite could accelerate wound healing and re-epithelialization. In summary, the composite material is an ideal dressing for accelerating hemostasis, preventing bacterial infection, and promoting wound healing.

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Biomimetic nanoengineered scaffold for enhanced full-thickness cutaneous wound healing

Cited by 95 publications

References 83 publications

Polyvinyl Alcohol/Chitosan and Polyvinyl Alcohol/Ag@MOF Bilayer Hydrogel for Tissue Engineering Applications

Polyvinyl Alcohol/Chitosan and Polyvinyl Alcohol/Ag@MOF Bilayer Hydrogel for Tissue Engineering Applications

Application of Nanomaterial in Hydrogels Related to Wound Healing

Bioinspired Design of Sericin/Chitosan/Ag@MOF/GO Hydrogels for Efficiently Combating Resistant Bacteria, Rapid Hemostasis, and Wound Healing

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