Polyvinyl Alcohol/Chitosan and Polyvinyl Alcohol/Ag@MOF Bilayer Hydrogel for Tissue Engineering Applications

Abstract

In this paper, polyvinyl alcohol/Ag-Metal-organic framework (PVA/Ag@MOF) and polyvinyl alcohol/chitosan (PVA/CS) were used as the inner and outer layers to successfully prepare a bilayer composite hydrogel for tissue engineering scaffold. The performance of bilayer hydrogels was evaluated. The outer layer (PVA/CS) has a uniform pore size distribution, good water retention, biocompatibility and cell adhesion ability. The inner layer (PVA/Ag@MOF) has good antibacterial activity and poor biocompatibility. PVA, PVA/0.1%Ag@MOF, PVA/0.5%Ag@MOF, and PVA/1.0%Ag@MOF show anti-microbial activity in ascending order. However, its use as an inner layer avoids direct contact with cells and prevents infection. The cell viability of all samples was above 90%, indicating that the bilayer hydrogel was non-toxic to A549 cells. The bilayer hydrogel scaffold combines the advantages of the inner and outer layers. In summary, this new bilayer composite is an ideal lung scaffold for tissue engineering.

Fabrication of a PVA-Based Hydrogel Microneedle Patch

“…In addition, it showed appropriate cell viability even when compared with commercially available products. As a result of this, the cell viability of the PVA hydrogel and the Niacinamide hydrogel in PVA-based hydrogel is applicable to humans, observing that cell morphology was well formed in 80–100% …”

“…As a result of this, the cell viability of the PVA hydrogel and the Niacinamide hydrogel in PVA-based hydrogel is applicable to humans, observing that cell morphology was well formed in 80–100%. 19 …”

Multifunctional hydrogel containing platelet camouflaged ultra-small silver nanoparticles accelerates diabetic wound healing in Type 1 Diabetic rats

“…After reached 400℃, the usAgNPs could not be further degrade. [27] The infrared absorption peaks showed in IR spectrum (Fig. 2E) were summarized as follows: the observed peak at 1517 cm − 1 was attributed to C − N stretching, N − H stretching was observed at 1729 cm − 1 .…”

Metal–organic frameworks as a therapeutic strategy for lung diseases

“…However, Ag-MOFs are highly cytotoxic, so we designed a double hydrogel to avoid this limitation. Zhang et al 159 designed PVA/CS hydrogels as the outer layer and PVA/Ag-MOF hydrogels as the inner layer to solve the problem of high cytotoxicity of Ag-MOFs (Fig. 8).…”