Fabrication of a PVA-Based Hydrogel Microneedle Patch

Oh, Na Gyeong; Hwang, Sang Youn; Na, Yang Ho

doi:10.1021/acsomega.2c01993

Cited by 41 publications

(26 citation statements)

References 24 publications

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“…The yield strength for the patch is 0.00030 N/mm 2 . The deformation force was found to be 4.2 N. This is in the range of what others have found with similar PVA microneedles [ 63 ].…”

Section: Resultssupporting

confidence: 70%

Direct Capture and Early Detection of Lyme Disease Spirochete in Skin with a Microneedle Patch

et al. 2022

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Borrelia burgdorferi sensu lato family of spirochetes causes Lyme disease (LD) in animals and humans. As geographic territory of ticks expands across the globe, surveillance measures are needed to measure transmission rates and provide early risk testing of suspected bites. The current standard testing of LD uses an indirect two-step serological assay that detects host immune reactivity. Early detection remains a challenge because the host antibody response develops several weeks after infection. A microneedle (MN) device was developed to sample interstitial fluid (ISF) and capture spirochetes directly from skin. After sampling, the MN patch is easily dissolved in water or TE buffer, and the presence of spirochete DNA is detected by PCR. Performance was tested by spiking porcine ear skin with inactivated Borrelia burgdorferi, and showed an approximate recovery of 80% of spirochetes. With further development, this simple direct PCR method could be a transformative approach for early detection of the causative agent of Lyme disease and enable rapid treatment to patients when infection is early, and numbers of systemic spirochetes are low.

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“…The yield strength for the patch is 0.00030 N/mm 2 . The deformation force was found to be 4.2 N. This is in the range of what others have found with similar PVA microneedles [ 63 ].…”

Section: Resultssupporting

confidence: 70%

Direct Capture and Early Detection of Lyme Disease Spirochete in Skin with a Microneedle Patch

et al. 2022

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“…It supported that PVA MNP was flexible rather than brittle. 40 Such a property was also endowed to the PVA-containing MNP-i samples, which resulted in the unfound fracture forces in Figure 2d−…”

Section: Resultsmentioning

confidence: 96%

Electrostatic-Interaction-Aided Microneedle Patch for Enhanced Glucose-Responsive Insulin Delivery and Three-Meal-Per-Day Blood-Glucose Regulation

Shen,

Yu,

Wang

et al. 2024

ACS Appl. Mater. Interfaces

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The phenylborate-ester-cross-linked hydrogel microneedle patch (MNP) was promising in the diabetic field for the glucose-responsive insulindelivering property and simple fabrication process. However, the unfit design of the charging microneedle network limited the improvement of blood-glucose regulating performances. In this work, insulin-loaded phenylborate-ester-crosslinked MNPs, with the polyzwitterion property, were constructed based on the modified ε-polylysine and poly(vinyl alcohol). The relationship between the charging nature of the MNP network and insulin release was verified by regulating the content of postprotonated positively charged amino groups. The elaborately designed MNP possessed improved glucose-responsive insulindelivering performance. The in vivo study revealed the satisfactory results on blood-glucose regulation by the optimized MNP under the mimic three-mealper-day mode. Moreover, the insulin bioactivity in the MNP could be maintained for 2 weeks under 25 °C. In summary, this work developed an effective strategy to improve the glucose-responsive phenylborateester-cross-linked MNP and enhance its potential for clinical transformation.

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“…Microneedle systems are minimally invasive and painless transdermal drug delivery devices that can be accommodated into adhesive hydrogel patches. [49][50][51][52] Hydrogel patches have been successfully combined with microneedle systems for effective drug delivery. 53 When designing such a hydrogel-forming microneedle, the length of the needles is an important parameter.…”

Section: Microneedlesmentioning

confidence: 99%

Engineering multifunctional adhesive hydrogel patches for biomedical applications

Chakraborty,

Alexander,

Luo

et al. 2023

Interdisciplinary Medicine

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Traditional patches, such as sticking plaster or acrylic adhesives used for over a hundred years, lack functionality. To address this issue of poor functionality, adhesive hydrogel patches have emerged as an efficient bioactive multifunctional alternative. Hydrogels are three‐dimensional, water‐swellable, and polymeric materials closely resembling the native tissue architecture. The physicochemical properties of hydrogels can be modified easily, allowing them to be suitable for various biomedical applications. Moreover, adhesive properties can be imparted to hydrogels through physicochemical manipulations, making them ideal candidates for supplementing or replacing traditional sticking plaster. As a result, sticky hydrogel patches are widely used for transdermal drug delivery and have even found commercial purposes. Beyond transdermal delivery, such hydrogel patches have also found applications in cardiac therapy, cancer research, and biosensing, among other applications. In this mini‐review, we critically discuss the challenges of fabricating multifunctional adhesive hydrogel patches. Furthermore, we introduce some of the chemical strategies involved with fabricating the patches. We also review their emerging biomedical applications. Finally, we explore their potential future in the flourishing field of tissue engineering and drug delivery.

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Fabrication of a PVA-Based Hydrogel Microneedle Patch

Cited by 41 publications

References 24 publications

Direct Capture and Early Detection of Lyme Disease Spirochete in Skin with a Microneedle Patch

Direct Capture and Early Detection of Lyme Disease Spirochete in Skin with a Microneedle Patch

Electrostatic-Interaction-Aided Microneedle Patch for Enhanced Glucose-Responsive Insulin Delivery and Three-Meal-Per-Day Blood-Glucose Regulation

Engineering multifunctional adhesive hydrogel patches for biomedical applications

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