2021
DOI: 10.1177/22808000211005384
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Biomimetic oligopeptide formed enamel-like tissue and dentin tubule occlusion via mineralization for dentin hypersensitivity treatment

Abstract: Objective: Dentin hypersensitivity (DH) is a common oral disease with approximately 41.9% prevalence. Reconstruction of dental hard tissues is the preferred treatment for relieving DH. Here, we applied biomineralization method using oligopeptide simulating cementum protein 1 (CEMP1) to regenerate hard tissues on demineralized dentin. Methods: The self-assembly and biomineralization property of the oligopeptide were detected by scanning electron microscopy (SEM), circular dichroism spectroscopy, and transmissio… Show more

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Cited by 5 publications
(2 citation statements)
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“…The roles of templates in the biomimetic mineralization include controlling the shape and size of inorganic structures, chemo-selectivity for inorganic synthesis, inorganic localization, and higher-order assembly. 592 Natural templates such as teeth and bone are often used to mediate the mineralization process to form BMT-like structures, for example, teeth, 554,[594][595][596] demineralized bone, 597 wood, 555 cartilage, 598 and fish scales. 599 Liu et al 554 reported the preparation of continuously structured inorganic materials by crosslinking ionic oligomers.…”
Section: Template-assisted Mineralizationmentioning
confidence: 99%
“…The roles of templates in the biomimetic mineralization include controlling the shape and size of inorganic structures, chemo-selectivity for inorganic synthesis, inorganic localization, and higher-order assembly. 592 Natural templates such as teeth and bone are often used to mediate the mineralization process to form BMT-like structures, for example, teeth, 554,[594][595][596] demineralized bone, 597 wood, 555 cartilage, 598 and fish scales. 599 Liu et al 554 reported the preparation of continuously structured inorganic materials by crosslinking ionic oligomers.…”
Section: Template-assisted Mineralizationmentioning
confidence: 99%
“…If the P 11 -4 complex, formed through the self-assembly of the oligomeric β-sheet-forming peptides, exhibits a similar acicular shape, nanometric size, and crystallinity to natural enamel, it can be considered biomimetic. This biomimetic nature allows the P 11 -4 complex to closely resemble the mineral structure of enamel and potentially support the regeneration and remineralization of dental hard tissues [ 21 ].…”
Section: Self-assembling Peptide P 11 -4 For Ename...mentioning
confidence: 99%