Biomimetic synthesis of novel polyvinyl alcohol/hydroxyapatite composite microspheres for biomedical applications

Ke-min, Xue; Teng, Sheng; Niu, Niu; Wang, Peng

doi:10.1088/2053-1591/aadc7d

Cited by 12 publications

(9 citation statements)

References 35 publications

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“…Microspheres. The procedures of drug loading and release were performed according to the literature [18]. Briefly, the drug-loading experiment was carried out by dispersing 0.1 g of the microspheres into 20 mL of the PBS solution containing 5 mg/mL of VH.…”

Section: Drug Loading and In Vitro Release Of The Cs-sio 2 Hybridmentioning

confidence: 99%

Synthesis, Characterization, and In Vitro Drug Delivery of Chitosan-Silica Hybrid Microspheres for Bone Tissue Engineering

Niu

Teng

Zhou

et al. 2019

Journal of Nanomaterials

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Chitosan-silica (CS-SiO2) hybrid microspheres were prepared through the combined process of sol-gel and emulsification-crosslinking. Their composition, morphology, in vitro bioactivity, and drug release behavior were investigated. The results showed that, when 20 wt% SiO2 was incorporated, the as-prepared CS-SiO2 hybrid microspheres exhibited a regular spherical shape, a high dispersity, and a uniform microstructure. Their average particle diameter was determined to be about 24.0 μm. The in situ deposited inorganic phase of the hybrid microspheres was identified as amorphous SiO2, and its actual content was determined by the TG analysis. As compared with the pure chitosan microspheres, the CS-SiO2 hybrid microspheres displayed a greatly improved in vitro bioactivity. Vancomycin hydrochloride (VH) was selected as a model drug. It was demonstrated that the CS-SiO2 hybrid microspheres presented a good capacity for both loading and sustained release of VH. Moreover, the increase of the SiO2 content efficiently slowed down the drug release rate of the CS-SiO2 hybrid microspheres.

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Section: Drug Loading and In Vitro Release Of The Cs-sio 2 Hybridmentioning

confidence: 99%

Synthesis, Characterization, and In Vitro Drug Delivery of Chitosan-Silica Hybrid Microspheres for Bone Tissue Engineering

Niu

Teng

Zhou

et al. 2019

Journal of Nanomaterials

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“…12 Zhang HG et al 13 using glutamic acid as the modulator, prepared mesoporous hydroxyapatite nanoparticles with ribbon-like morphology. Researchers have also used various polymers such as polyvinyl alcohol (PVA), 14 polyacrylic acid (PAA), 15 polyethylene glycol (PEG), 16 etc. to control the morphology or to afford a pattern for the synthesis of hydroxyapatite nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Tailoring the morphological features of sol–gel synthesized mesoporous hydroxyapatite using fatty acids as an organic modifier

et al. 2019

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“…Hydroxyapatite was synthesized by the liquid-phase method using microwave radiation at pH~11 according to the scheme [ 33 , 34 , 35 , 36 ]: 10Ca(NO 3 ) 2 + 6(NH 4 ) 2 HPO 4 + 8NH 4 OH → Ca 10 (PO 4 ) 6 (OH) 2 + 20NH 4 NO 3 + 6H 2 O …”

Section: Methodsmentioning

confidence: 99%

“…The obtained precipitate was settled in the mother liquor. Then it was filtered under vacuum and dried at room temperature within 24 h [ 35 , 36 ].…”

Section: Methodsmentioning

confidence: 99%

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Cryo-Structured Materials Based on Polyvinyl Alcohol and Hydroxyapatite for Osteogenesis

Lytkina

Fedorishin

Kalachikova

et al. 2021

JFB

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The application of various materials in biomedical procedures has recently experienced rapid growth. One of the areas is the treatment of many of different types of bone-related diseases and disorders by using biodegradable polymer-ceramic composites. We have developed a material based on cryogel polyvinyl alcohol, mineralized with calcium phosphate. Composites were obtained by cyclic freezing-thawing, the synthesis of calcium phosphates was carried out in situ under the influence of microwave radiation with heating and stirring. The components of the composites were determined using the methods of IR-spectroscopy and scanning electron microscopy and electron probe microanalyzer, as well as their morphology and surface properties. The biological compatibility of the material was investigated in vivo for a Wistar rat. The assessment of the quality of bone formation between the cryogel-based implant and the damaged bone was carried out by computed tomography. An improvement in the consolidation of the bone defect is observed in the bone with the composite in comparison with the control bone.

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Biomimetic synthesis of novel polyvinyl alcohol/hydroxyapatite composite microspheres for biomedical applications

Cited by 12 publications

References 35 publications

Synthesis, Characterization, and In Vitro Drug Delivery of Chitosan-Silica Hybrid Microspheres for Bone Tissue Engineering

Synthesis, Characterization, and In Vitro Drug Delivery of Chitosan-Silica Hybrid Microspheres for Bone Tissue Engineering

Tailoring the morphological features of sol–gel synthesized mesoporous hydroxyapatite using fatty acids as an organic modifier

Cryo-Structured Materials Based on Polyvinyl Alcohol and Hydroxyapatite for Osteogenesis

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