BioMOF-Mn: An Antimicrobial Agent and an Efficient Nanocatalyst for Domino One-Pot Preparation of Xanthene Derivatives

Abstract

In this paper, a new Mn-based metal–organic framework [UoB-6] was obtained via a one-step ultrasonic irradiation method with the ligand (H2bdda: 4,4′-(1,4-phenylenebis­(azaneylylidene))­bis­(methaneylylidene))­dibenzoic acid. The structural integrity of the synthesized BioMOF-Mn was corroborated by FT-IR, EDX, ICP, XRD, TEM, DLS, FESEM, and BET-BJH analyses. The aerobic oxidative domino reaction of benzyl alcohols or aldehydes with dimedone derivatives was performed in the presence of the UoB-6 catalyst to produce xanthene derivatives in good yields. Hot filtration and Hg poisoning tests proved the heterogeneous nature of the catalyst. Novel synthesized xanthene-based bis-aldehydes were introduced as potent HDAC1 inhibitors according to molecular docking calculations. Finally, the inhibitory activities of Mn-MOF nanoparticles were evaluated on Escherichia coli and Candida albicans. The MIC, MBC, and MFC values were determined from 2048 to 4096 μg·mL–1 according to antimicrobial susceptibility testing methods. The inhibitory effects of antimicrobial agents can be exacerbated when loaded on BioMOFs.

Ag/GO/Fe3O4/γ-Fe2O3 Nanocomposite for Green-Light-Driven Photocatalytic Oxidation of 5-Hydroxymethylfurfural to 5-Hydroxymethyl-2-furancarboxylic Acid

“…Wide and increasing attention to these issues requires that the chemical industries revise their activity process to use new and more accessible energies as much as possible and, on the other hand, to reduce the harmful effects on the environment . This way, a combination of environmental, health, safety, and economic considerations will be involved in the production of chemical products. − Nowadays, polymers have attracted much attention due to their wide range of applications, including antibacterial composites, solar cells, sensors, supercapacitors, microwave absorbers, self-cleaning structures, self-healing materials, and photocatalysts . Photocatalytic processes have been utilized for years as an environmental solution in industrialized countries worldwide .…”

TiO2/g-C3N4/SO3H(IL): Unique Usage of Ionic Liquid-Based Sulfonic Acid as an Efficient Photocatalyst for Visible-Light-Driven Preparation of 5-HMF from Cellulose and Glucose

“…Heterogeneous acidic catalysts are endowed with several favorable attributes such as lower costs and ease of separation and recycling. Consequently, an array of heterogeneous catalysts, namely, zeolites, sulfonated carbon-based materials, metal oxides, polymers, − resins, fused salts, and metal–organic frameworks, − have been deployed to transform cellulose or related saccharides into HMF, as exemplified by SnCl 4 , AlCl 3 , AlCl 3 /HCl, CrCl 3 /B­(OH) 3 , MgCl 2 , and CrCl 2 . Although the aforementioned catalysts offered reasonable yields, they were plagued by several shortcomings such as severe reaction conditions, higher cost of enzymes, and their thermal instability, and production of acidic sludge as well as reactor corrosion, which limit their large-scale adoption in the industry. , Ultimately, in view of the abundance and inexpensive nature, focus has centered around the meaningful dehydration of cellulose and glucose to 5-HMF, which necessitated essential requirements to develop efficient and eco-friendly catalysts for deployment in relatively greener solvents.…”

From Metal Complexes to BioMOFs: An Experimental Proposal for Teaching Coordination Chemistry Concepts

“…Although there are a variety of proposals for inorganic chemistry experiments involving MOFs, − none of them are specifically focused on BioMOFs or MBioFs. This class of compounds has currently attracted considerable interest because it can be potentially applied to solve important problems such as antimicrobial resistance and disease treatment, for example. − Thus, it is relevant to arouse the interest of the students for this kind of material.…”