Biomolecular and bioanalytical applications of infrared spectroscopy – A review

Beć, Krzysztof B.; Grabska, Justyna; Huck, Christian W.

doi:10.1016/j.aca.2020.04.015

Cited by 155 publications

(57 citation statements)

References 220 publications

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“…On the other hand, in several others areas it competes with better established techniques such as infrared (IR, i.e., mid-infrared, MIR; 4000-400 cm −1 ; 2500-25,000 nm) and Raman spectroscopy. The typical key areas are e.g., bioanalytical research and biomedical diagnosis, in which NIR spectroscopy has typically been shadowed by IR and Raman techniques [4][5][6][7][8], and where it still has room to progress in popularity. As the consequence of several reasons, with some exceptions, the full potential of NIR spectroscopy in bio-applications yet remains to be uncovered.…”

Section: Introductionmentioning

confidence: 99%

Near-Infrared Spectroscopy in Bio-Applications

2020

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Near-infrared (NIR) spectroscopy occupies a specific spot across the field of bioscience and related disciplines. Its characteristics and application potential differs from infrared (IR) or Raman spectroscopy. This vibrational spectroscopy technique elucidates molecular information from the examined sample by measuring absorption bands resulting from overtones and combination excitations. Recent decades brought significant progress in the instrumentation (e.g., miniaturized spectrometers) and spectral analysis methods (e.g., spectral image processing and analysis, quantum chemical calculation of NIR spectra), which made notable impact on its applicability. This review aims to present NIR spectroscopy as a matured technique, yet with great potential for further advances in several directions throughout broadly understood bio-applications. Its practical value is critically assessed and compared with competing techniques. Attention is given to link the bio-application potential of NIR spectroscopy with its fundamental characteristics and principal features of NIR spectra.

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Section: Introductionmentioning

confidence: 99%

Near-Infrared Spectroscopy in Bio-Applications

2020

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“…Some of the limitations of affinity-type refractometric optical biosensors can be overcome using vibrational spectroscopic techniques, such as infrared (IR) [105,106] and Raman spectroscopy (Figure 3) [10,107]. These techniques measure the nonlinear interactions of the atoms and molecules present in the sample with incident electromagnetic radiation.…”

Section: Label-free Spectroscopic Sensors With Digital and Optical Amplificationmentioning

confidence: 99%

Roadmap on Universal Photonic Biosensors for Real-Time Detection of Emerging Pathogens

et al. 2021

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The COVID-19 pandemic has made it abundantly clear that the state-of-the-art biosensors may not be adequate for providing a tool for rapid mass testing and population screening in response to newly emerging pathogens. The main limitations of the conventional techniques are their dependency on virus-specific receptors and reagents that need to be custom-developed for each recently-emerged pathogen, the time required for this development as well as for sample preparation and detection, the need for biological amplification, which can increase false positive outcomes, and the cost and size of the necessary equipment. Thus, new platform technologies that can be readily modified as soon as new pathogens are detected, sequenced, and characterized are needed to enable rapid deployment and mass distribution of biosensors. This need can be addressed by the development of adaptive, multiplexed, and affordable sensing technologies that can avoid the conventional biological amplification step, make use of the optical and/or electrical signal amplification, and shorten both the preliminary development and the point-of-care testing time frames. We provide a comparative review of the existing and emergent photonic biosensing techniques by matching them to the above criteria and capabilities of preventing the spread of the next global pandemic.

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“…The IR spectra show that the wavenumbers of the ν(C=O)- triazine groups vibrational wavenumbers leads to the formation of chelate complex. Symmetric and asymmetric stretching vibrations of COOgroup belong to the bands in the 1300-1700 cm -1 spectral region with C=O absorption bands observed in the 1600-1700 cm -1 range (Na 2 CefTria•3.5H 2 O: ν as (COO -)=1602 cm -1 and ν s (COO -)=1395 cm -1 ) [32][33][34]. In the experimental IR spectrum of the complex ν as (COO -)=1576 cm -1 and ν s (COO -)=1362 cm -1 .…”

Section: Ir Spectroscopymentioning

confidence: 99%

“…The more energetically favorable s-cys-s-cys conformer geometry was used as a ceftriaxone dianion involved in the complex formation. The geometry of the CefTria 2dianion in that conformation was optimized with B3LYP density functional theory as in an earlier study [32].…”

Section: Computational Studiesmentioning

confidence: 99%

Complex of Ca(II) with Ceftriaxone: Synthesis, Structure, Spectral and Antibacterial Properties

Novikova¹,

Tsyplenkova²,

Кузубов³

et al. 2021

J. Sib. Fed. Chem.

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The calcium complex of ceftriaxone was synthesized and characterized by elemental, atomic-emission analysis, TGA, IR spectroscopy and density functional theory calculations. The luminescence and antibacterial properties of the ceftriaxone disodium and calcium complex were investigated. Ca(II) complex was obtained in a crystalline form, cell parameters of the compound were determined. Ceftriaxone was coordinated to the calcium ion by the oxygen of the triazine cycle in the 6th position, the nitrogen of the amine group of the thiazole ring, and the oxygens of the lactam carbonyl and carboxylate groups. The complex of Ca(II) with ceftriaxone was screened for antibacterial activity against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa, and the results were compared with the activity of ceftriaxone disodium salt

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Biomolecular and bioanalytical applications of infrared spectroscopy – A review

Cited by 155 publications

References 220 publications

Near-Infrared Spectroscopy in Bio-Applications

Near-Infrared Spectroscopy in Bio-Applications

Roadmap on Universal Photonic Biosensors for Real-Time Detection of Emerging Pathogens

Complex of Ca(II) with Ceftriaxone: Synthesis, Structure, Spectral and Antibacterial Properties

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