Biomolecules as promising ligands in the synthesis of metal nanoclusters: Sensing, bioimaging and catalytic applications

Kailasa, Suresh Kumar; Borse, Shraddha; Koduru, Janardhan Reddy; Murthy, Z.V.P.

doi:10.1016/j.teac.2021.e00140

Cited by 73 publications

(33 citation statements)

References 95 publications

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“…3 Fluorescence spectrophotometry is a widely used analytical technique for the chemical/biosensing of target molecules in homogenous assays. However, a low signal-to-noise ratio arises due to the detection limitations of some commonly used fluorescence-based nanotechnologies such as metal complexes, 4 metal nanoclusters, 5 organic dyes, 6 quantum dots, 7 and semiconductor nanocrystals. 8 For example, ultrasmall nanostructure materials displayed short circulation half-time and toxicity in the biosystem, while the decay lifetime of organic dyes (<100 ns) and metal complexes (≈ 10 μs) are short, which cause interference with the detection mechanism.…”

Section: Introductionmentioning

confidence: 99%

Applications of upconversion nanoparticles in analytical and biomedical sciences: a review

Borse

Rafique

Murthy

et al. 2022

Analyst

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Section: Introductionmentioning

confidence: 99%

Applications of upconversion nanoparticles in analytical and biomedical sciences: a review

Borse

Rafique

Murthy

et al. 2022

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“…In addition to better biocompatibility, biomolecule-protected NCs allow a wider selection of ligands, whose structure and functions are generally preserved after the synthesis [43,44]. Besides the advantages afforded by their use as templating agents, biomolecules play a prominent role also in endowing metal NCs with specific recognition capability for certain biomarkers, generating versatile multifunctional hybrid platforms for bioimaging applications [45]. Actually, the design of stable bioimaging probes with real-time monitoring ability, effective targeting, and good biocompatibility is highly desirable and could significantly contribute to improve early diagnosis and treatment of diseases.…”

Section: Hybrid Nanocluster-based Imaging Probesmentioning

confidence: 99%

Photoluminescent nanocluster-based probes for bioimaging applications

Bergamaschi

Metrangolo

Dichiarante

2022

Photochem Photobiol Sci

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In the continuous search for versatile and better performing probes for optical bioimaging and biosensing applications, many research efforts have focused on the design and optimization of photoluminescent metal nanoclusters. They consist of a metal core composed by a small number of atoms (diameter < 2-3 nm), usually coated by a shell of stabilizing ligands of different nature, and are characterized by molecule-like quantization of electronic states, resulting in discrete and tunable optical transitions in the UV-Vis and NIR spectral regions. Recent advances in their size-selective synthesis and tailored surface functionalization have allowed the effective combination of nanoclusters and biologically relevant molecules into hybrid platforms, that hold a large potential for bioimaging purposes, as well as for the detection and tracking of specific markers of biological processes or diseases. Here, we will present an overview of the latest combined imaging or sensing nanocluster-based systems reported in the literature, classified according to the different families of coating ligands (namely, peptides, proteins, nucleic acids, and biocompatible polymers), highlighting for each of them the possible applications in the biomedical field.

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“…As a bridge between atom and nanoparticle, metal nanoclusters (metal NCs, mainly Au, Ag and Cu) which are composed of a few to hundreds of mental atoms and covered with organic ligands on the surface of the metal core, have been receiving extensive attention due to their important roles in the fields of catalysis, sensing, electrochemistry, energy transfer and biomedicine [ 1 , 2 , 3 , 4 , 5 ]. Among various applications, metal nanoclusters are widely used as sensors because of their sensitive responses to temperature, pH value, metal ions and small biological molecules [ 6 , 7 , 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Supramolecular Self-Assembly of Atomically Precise Silver Nanoclusters with Chiral Peptide for Temperature Sensing and Detection of Arginine

Wang

Sun

et al. 2022

Nanomaterials

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Metal nanoclusters (NCs) as a new type of fluorescent material have attracted great interest due to their good biocompatibilities and outstanding optical properties. However, most of the studies on metal NCs focus on the synthesis, atomic or molecular assembly, whereas metal NCs ability to self-assemble to higher-level hierarchical nanomaterials through supramolecular interactions has rarely been reported. Herein, we investigate atomic precise silver NCs (Ag9-NCs, [Ag9(mba)9], where H2mba = 2-mercaptobenzoic acid) and peptide DD-5 were used to induce self-assembly, which can trigger an aggregation-induced luminescence (AIE) effect of Ag9-NCs through non-covalent forces (H-bond, π–π stacking) and argentophilic interactions [Ag(I)–Ag(I)]. The large Stokes shift (~140 nm) and the microsecond fluorescence lifetime (6.1 μs) indicate that Ag9-NCs/DD-5 hydrogel is phosphor. At the same time, the chirality of the peptide was successfully transferred to the achiral Ag9-NCs because of the supramolecular self-assembly, and the Ag9-NCs/DD-5 hydrogel also has good circularly polarized luminescence (CPL) properties. In addition, Ag9-NCs/DD-5 luminescent hydrogel is selective and sensitive to the detection of small biological molecule arginine. This work shows that DD-5 successfully induces the self-assembly of Ag9-NCs to obtain high luminescent gel, which maybe become a candidate material in the fields of sensors and biological sciences.

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Biomolecules as promising ligands in the synthesis of metal nanoclusters: Sensing, bioimaging and catalytic applications

Cited by 73 publications

References 95 publications

Applications of upconversion nanoparticles in analytical and biomedical sciences: a review

Applications of upconversion nanoparticles in analytical and biomedical sciences: a review

Photoluminescent nanocluster-based probes for bioimaging applications

Supramolecular Self-Assembly of Atomically Precise Silver Nanoclusters with Chiral Peptide for Temperature Sensing and Detection of Arginine

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