Biomonitoring for workplace exposure to copper and its compounds is currently not interpretable

Bevan, Ruth; Levy, Len

doi:10.1016/j.ijheh.2024.114358

Cited by 2 publications

References 51 publications

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Copper induces p53 unfolding in cancer cells, resulting in invasion and chemoresistance

von Grabowiecki,

Bell,

Richards

et al. 2024

Preprint

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Copper has been shown to play an important role in cancers, enhancing cell proliferation, remodelling the microenvironment and enhancing the function of oncogenes. Here we show that copper turns the tumour suppressor p53 protein into a pro-oncogenic protein. Mutations in the TP53 gene often lead to expression of various mutant p53 proteins. Mutant proteins often lose some or all wild type function and gain novel pro-tumourigenic functions, which can be partially attributed to protein unfolding. Here we show that copper accumulates in tumours, unfolds WTp53 and promotes chemoresistance. Unfolding of WT p53 results in interaction with mutant p53-specific interacting proteins TAp63 and Ago2 and promotes invasion. Interestingly, partially-functional p53 mutants that are frequently observed in lung cancers, are more affected by copper than WTp53. Our results suggest that small increases in copper impair WT p53 function and augment mutant p53 function, which could partially be restored by the chelator Trien.

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Copper induces p53 unfolding in cancer cells, resulting in invasion and chemoresistance

von Grabowiecki,

Bell,

Richards

et al. 2024

Preprint

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Copper ions: The invisible killer of cardiovascular disease (Review)

Wang,

Feng,

et al. 2024

Mol Med Rep

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Copper, a vital trace element, is indispensable for the maintenance of physiological functioning, particularly in the cardiac system. Unlike other forms of cell death such as iron death and apoptosis, copper-induced cell death has gained increasing recognition as a significant process influencing the development of cardiovascular diseases. The present review highlights the significance of maintaining copper homeostasis in addressing cardiovascular diseases. This review delves into the crucial roles of copper in physiology, including the metabolic pathways and its absorption, transport and excretion. It provides detailed insights into the mechanisms underlying cardiovascular diseases resulting from both excess and deficient copper levels. Additionally, it summarizes strategies for treating copper imbalances through approaches such as copper chelators and ion carriers while discussing their limitations and future prospects.

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Biomonitoring for workplace exposure to copper and its compounds is currently not interpretable

Cited by 2 publications

References 51 publications

Copper induces p53 unfolding in cancer cells, resulting in invasion and chemoresistance

Copper induces p53 unfolding in cancer cells, resulting in invasion and chemoresistance

Copper ions: The invisible killer of cardiovascular disease (Review)

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