Biomonitoring of bisphenols A, F, S in human milk and probabilistic risk assessment for breastfed infants

Dualde, Pablo; Pardo, Olga; Corpas-Burgos, Francisca; Kuligowski, Julia; Gormáz, María; Vento, Máximo; Pastor, Agustı́n; Yusà, Vicent

doi:10.1016/j.scitotenv.2019.03.024

Cited by 78 publications

(35 citation statements)

References 49 publications

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“…The 10% ethanol was presumed to be the cause, and it may counteract the effects of BPA at a very low dose, such as 0.05 mg·kg −1 ·day −1 . According to a recent scientific report by Dualde et al (2019), the estimated daily intake of total BPA for breastfed infants amounted to a geometric mean of 0.04 μg/kg bw and a 95th percentile of 1.0 μg/kg bw. The doses we used in this study are much higher than the doses infants are exposed to.…”

Section: Discussionmentioning

confidence: 99%

“…BPA was shown to be detectable in the urine of almost all adults and children tested, the serum of pregnant women, as well as in cord blood and placental tissue (Berger et al, 2018; Huang et al, 2018; Lee et al, 2018; Zhang, Sun, & Kannan, 2013). Additionally, BPA can pass through the placenta to the fetus and via breast milk to neonates (Balakrishnan, Henare, Thorstensen, Ponnampalam, & Mitchell, 2010; Corbel et al, 2019; Dualde et al, 2019), and may have potential effects since gestational development (Nishikawa et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

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Neonatal exposure to bisphenol A advances pubertal development in female rats

Qiu

Sun

et al. 2020

Molecular Reproduction Devel

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Neonatal exposure to bisphenol A (BPA) is hypothesized to advance pubertal development. However, the effects of neonatal BPA exposure on pubertal development has not been described. In this study, female Sprague-Dawley rats were exposed to 0.05, 0.5, 5, or 10 mg·kg −1 ·day −1 BPA, or corn oil vehicle alone from postnatal day 1 (PND1) to PND10 via subcutaneous injection. We evaluated day of vaginal opening (DVO), ovarian morphology, serum hormone concentrations, and hypothalamic expression of Gnrh1 and Kiss1 in female rats at PND35. DVO was significantly advanced in rats exposed to 5 and 10 mg·kg −1 ·day −1 BPA. Serum hormone concentrations increased as BPA dose increased. Additionally, hypothalamic Gnrh1 and Kiss1 expression were increased with BPA exposure; rats exposed to 10 mg·kg −1 ·day −1 BPA had significantly upregulated hypothalamic Gnrh1 and Kiss1 expressions in terms of both messenger RNA and protein levels. Our results suggest that exposure to a 10 mg·kg −1 ·day −1 dose of BPA might advance pubertal development significantly. In addition, within the range of 0 to 10 mg·kg −1 ·day −1 , neonatal exposure to BPA may affect pubertal development in a dose-dependent manner.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Neonatal exposure to bisphenol A advances pubertal development in female rats

Qiu

Sun

et al. 2020

Molecular Reproduction Devel

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“…Results of both animal and human studies have revealed the toxic effects of bisphenols. Increased levels of bisphenols are found in human body fluids including in urine, serum, placental tissue, umbilical cord blood, and breast milk [60,78,84,97,124]. These chemicals affect animal and human organisms by interactions with estrogen, androgen, and aryl hydrocarbon receptors, and disrupt the function of the endocrine system, including altering the functions of sex hormones, insulin, leptin, adiponectin, or thyroxin.…”

Section: Discussionmentioning

confidence: 99%

“…Increased urinary BPA level has also been associated with decreased thyroid-stimulating hormone and increased levels of free triiodothyronine hormone in a Chinese population aged 40 years or older [58]. BPA, BPF, and BPS have also been detected in human breast milk samples from Spanish mothers [59,60] (Table 2).…”

Section: Endocrine Disruption and Reproductive Abnormalitiesmentioning

confidence: 99%

Bisphenols as a Legacy Pollutant, and Their Effects on Organ Vulnerability

Kim

Kumar

et al. 2019

IJERPH

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Bisphenols are widely used in the synthesis of polycarbonate plastics, epoxy resins, and thermal paper, which are used in manufacturing items of daily use. Packaged foods and drinks are the main sources of exposure to bisphenols. These chemicals affect humans and animals by disrupting the estrogen, androgen, progesterone, thyroid, and aryl hydrocarbon receptor functions. Bisphenols exert numerous harmful effects because of their interaction with receptors, reactive oxygen species (ROS) formation, lipid peroxidation, mitochondrial dysfunction, and cell signal alterations. Both cohort and case-control studies have determined an association between bisphenol exposure and increased risk of cardiovascular diseases, neurological disorders, reproductive abnormalities, obesity, and diabetes. Prenatal exposure to bisphenols results in developmental disorders in animals. These chemicals also affect the immune cells and play a significant role in initiating the inflammatory response. Exposure to bisphenols exhibit age, gender, and dose-dependent effects. Even at low concentrations, bisphenols exert toxicity, and hence deserve a critical assessment of their uses. Since bisphenols have a global influence on human health, the need to discover the underlying pathways involved in all disease conditions is essential. Furthermore, it is important to promote the use of alternatives for bisphenols, thereby restricting their uses.

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“…Increased urinary BPA level has also been associated with decreased thyroid-stimulating hormone and increased levels of free triiodothyronine hormone in a Chinese population aged 40 years or older [60]. BPA, BPF, and BPS have also been detected in human breast milk samples from Spanish mothers [61,62] (Table 2).…”

Section: Endocrine Disruption and Reproductive Abnormalitiesmentioning

confidence: 99%

Bisphenols as A Legacy Pollutant, and Their Effects on Organ Vulnerability

Kim¹,

Kumar²,

Kumar³

et al. 2019

Preprint

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Bisphenols are widely used in the synthesis of polycarbonate plastics, epoxy resins and thermal paper, which are used in manufacturing items of daily use. Packaged foods and drinks are the main sources of exposure to bisphenols. These chemicals affect humans and animals by disrupting the estrogen, androgen, progesterone, thyroid, and aryl hydrocarbon receptor functions. Bisphenols exert numerous harmful effects because of their interaction with receptors, ROS formation, lipid peroxidation, mitochondrial dysfunction, and cell signal alterations. Both cohort and case-control studies have determined an association between bisphenol exposure and increased risk of cardiovascular diseases, neurological disorders, reproductive abnormalities, obesity, and diabetes. Prenatal exposure to bisphenol results in developmental disorders in animals. These chemicals also affect the immune cells and play a significant role in initiating the inflammatory response. Exposure to bisphenols exhibit age, gender, and dose-dependent effects. Even at low concentrations, bisphenols exert toxicity, and hence deserve a critical assessment for their uses. Since bisphenols have a global influence on human health, the need to discover the underlying pathways involved in all disease conditions is essential. Furthermore, it is important to promote the use of alternatives for bisphenols, thereby restricting their uses.

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Biomonitoring of bisphenols A, F, S in human milk and probabilistic risk assessment for breastfed infants

Cited by 78 publications

References 49 publications

Neonatal exposure to bisphenol A advances pubertal development in female rats

Neonatal exposure to bisphenol A advances pubertal development in female rats

Bisphenols as a Legacy Pollutant, and Their Effects on Organ Vulnerability

Bisphenols as A Legacy Pollutant, and Their Effects on Organ Vulnerability

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