Biomonitoring of genotoxic exposure among stainless steel welders

Knudsen, Lisbeth E.; Boisen, Thorkil; Christensen, Jytte Molin; Jelnes, Jens Erik; Jensen, Gunde Egeskov; Jensen, Jørn C.; Lundgren, Karsten; Lundsteen, Claes; Pedersen, Bo Vest; Wassermann, Karsten; Wilhardt, Peter; Wulf, Hans Christian; Zebitz, Ursula

doi:10.1016/0165-1218(92)90255-x

Cited by 57 publications

(26 citation statements)

References 33 publications

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“…In the literature, there are few in vitro studies regarding peripheral lymphocytes of welders (12)(13)(14), and this study will contribute to the literature. Because the genotoxicity was reported with the parameters of the sister chromatid exchange, the chromosome aberration, and the polymorphisms in these studies, this study is the first report for genotoxicity with the parameters of MN and RI in welders.…”

Section: Discussionmentioning

confidence: 99%

The in vitro determination of genotoxicity in peripheral lymphocytes of welders exposed to fumes from metal-arc welding

Şener¹,

Eroğlu

2013

Turk J Med Sci

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To foster the practical development of the constructed wetlands used for water quality enhancement in Turkey, 2 vertical subsurface flow pilot-scale constructed wetlands were implemented on the METU campus, Ankara, Turkey. Both of the wetlands were planted with Phragmites australis and operated identically at a flowrate of 3 m 3 .d −1 and a hydraulic loading rate (HLR) of 0.100 m.d −1 , intermittently. The main objective of the research was to quantify the effect of different substrates (gravel and blast furnace granulated slag) on the nutrient removal performance of the constructed wetlands in the prevailing climate of Ankara. According to the monitoring study (July 2002-January 2003), concentration based average removal efficiencies for the slag and gravel reed beds were as follows: TSS (64% and 62%), COD (49% and 40%), NH + 4 -N (88% and 58%), TN (41% and 44%), TP (63% and 9%) and PO 3− 4 -P (60% and 4%). In general, the treatment performance of the slag system was better than that of the gravel system.

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Section: Discussionmentioning

confidence: 99%

The in vitro determination of genotoxicity in peripheral lymphocytes of welders exposed to fumes from metal-arc welding

Şener¹,

Eroğlu

2013

Turk J Med Sci

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“…In addition, a significant correlation was found between the frequency of SCE and urinary chromium concentrations. Similarly, Knudsen et al [1992] described higher frequencies of chromosomal aberration (CA) and SCE in stainless steel welders, and Costa et al [1993] reported higher frequencies of DNAprotein crosslinks in a group of 21 welders than in a group of 26 controls. CA and SCE frequencies were significantly elevated in 42 welders engaged in manual arc and stainless steel welding [Jelmert and al., 1994]; however, tungsten inert arc welders had no increases in CA or SCE [Jelmert et al, 1995].…”

Section: Introductionmentioning

confidence: 99%

“…As indicated above, biological endpoints, such as DNA damage, can be monitored by analysis of CA and SCE [Jelmert et al, 1995], micronuclei in either buccal cells [Danadevi et al, 2004] or lymphocytes [Medeiros et al, 2003], DNA-protein crosslinks [Costa et al, 1993], or unscheduled DNA synthesis [Knudsen et al, 1992]. In addition, the alkaline Comet assay is a rapid and sensitive technique to assess DNA strand breaks and alkali-labile sites in individual cells.…”

Section: Introductionmentioning

confidence: 99%

Assessment of occupational exposure to welding fumes by inductively coupled plasma‐mass spectroscopy and by the alkaline Comet assay

Botta¹,

Iarmarcovai²,

Chaspoul³

et al. 2006

Environ and Mol Mutagen

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Welding fumes are classified as possibly carcinogenic to humans (Group 2B) by the International Agency for Research on Cancer. In the current study, blood and urine concentrations of aluminum (Al), cadmium (Cd), cobalt (Co), chromium (Cr), manganese (Mn), nickel (Ni), lead (Pb), and zinc (Zn) were monitored by inductively coupled plasma-mass spectrometry (ICP-MS) in 30 welders and in 22 controls. In addition, DNA damage was examined in the lymphocytes of these subjects by the alkaline Comet assay. Two biological samples were taken from the welders at the beginning (BW) and at the end (EW) of a work week. In controls, collection of samples was limited to BW. Blood concentrations of Cd, Co, Cr, Ni, and Pb were higher in the welders than in the control group while higher concentrations of Al, Cd, Co, Cr, Ni, and Pb were detected in welder urines.There was no significant difference in the metal concentrations for the BW and EW welder samples. Increased levels of DNA damage were found in lymphocytes from welders as compared to the controls, and 20/30 welders had higher levels of DNA lesions in the EW than in the BW samples. Age had a significant effect on DNA damage in the control group. Spearman's rank correlation analysis indicated that there were positive correlations between blood concentrations of Al, Co, Ni, and Pb and the levels of DNA damage. A negative correlation was found between DNA damage and Mn in blood, while there was a positive correlation between urinary Mn concentration and DNA damage. These data indicate that occupational exposure to welding fumes increases DNA damage in lymphocytes. Environ. Mol. Mutagen. 47:284-295, 2006. V V C 2006 Wiley-Liss, Inc.

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confidence: 99%

“…First, fumes from the welding of stainless steel (SS), but not mild steel (MS), contain hexavalent chromium (3)(4)(5). Second, the welding of stainless steel may lead to pulmonary absorption of hexavalent chromium (4)(5)(6)(7), and autopsy studies of former chromateexposed workers have shown high concentrations of hexavalent chromium in all examined organs (8,9). Third, animal experimental studies have demonstrated a mutagenic capability for hexavalent chromium in somatic cells and germ cells, and hexavalent chromium administered to a male rodent can impair the viability of embryos fathered by that male (1,(10)(11)(12).…”

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confidence: 99%