Biomonitoring of polycyclic aromatic hydrocarbons from coke oven emissions and reproductive toxicity in nonsmoking workers

Jeng, Hueiwang Anna; Pan, Chih-Hong; Lin, Wen‐Yi; Wu, Ming-Tsang; Taylor, Steven L.; Chang-Chien, Guo-Ping; Zhou, Guodong; Diawara, Norou

doi:10.1016/j.jhazmat.2012.11.008

Cited by 51 publications

(24 citation statements)

References 54 publications

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“…The later two studies performed among the same group of Taiwanese workers found that urinary 1-OHP does not significantly correlate with semen quality; however, PAHs with heavy molecular weight, e.g., benzo(g,h,i)perylene and benzo(k)fluoranthene, negatively correlate with morphology and motility of sperm cells (p = 0.02 and 0.002, p = 0.04 and 0.04, respectively) [39]. The second study by did not find any significant differences in sperm concentrations, vitality and DNA fragmentation between the topside oven workers (exposed) and the side oven workers (unexposed) [40]. Using only a single urine sample to predict metabolite concentrations over longer periods [53] may be a potential limitation of our study, but as far as we are aware, all the study participants had not changed their life styles or environments for several months prior to sample collection so their PAHs exposure may be relatively stable over time.…”

Section: Ijomeh 2013;26(5) 797mentioning

confidence: 78%

Association between a biomarker of exposure to polycyclic aromatic hydrocarbons and semen quality

Jurewicz¹,

Radwan²,

Sobala³

et al. 2013

International Journal of Occupational Medicine and Environmental Health

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Objectives: Growing evidence supports the reproductive and developmental toxicity of polycyclic aromatic hydrocarbons (PAHs) from prenatal and postnatal exposure, but the results of epidemiological studies regarding harmful effects of PAHs exposure on male reproductive system still remain limited and inconclusive. The aim of the present study was to investigate the relationship between 1-hydroxypyrene, a biomarker of polycyclic aromatic hydrocarbons exposure and semen quality. Materials and Methods:The study population consisted of 277 men attending an infertility clinic for diagnostic purposes and having normal semen concentration of 20-300 mln/ml or slight oligozoospermia (semen concentration: 15-20 mln/ml) (WHO 1999). All the men were healthy and under 45 years of age. All participants were interviewed and provided a semen sample. The interview included questions concerning demographics, socio-economic status, medical history related to past diseases which may have an impact on semen quality, lifestyle factors and occupational information. Concentrations of 1-hydroxypyrene (1-OHP) in the urine samples were analyzed using high performance liquid chromatography (HPLC). Results: A positive association was found between the level of 1-OHP in urine and sperm neck abnormalities as well as the percentage of static sperm cells (p = 0.001, p = 0.018, respectively). Additionally, exposure to PAHs measured by 1-OHP in urine decreased semen volume and the percentage of motile sperm cells (p = 0.014, p = 0.0001, respectively). Conclusions: Presented findings indicate that the environmental level of PAHs exposure adversely affects male semen quality. The future large-scale studies should incorporate different biomarkers to generate a more accurate and full assessment of the effects of PAHs exposure on male fertility.

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Section: Ijomeh 2013;26(5) 797mentioning

confidence: 78%

Association between a biomarker of exposure to polycyclic aromatic hydrocarbons and semen quality

Jurewicz¹,

Radwan²,

Sobala³

et al. 2013

International Journal of Occupational Medicine and Environmental Health

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“…Recently, epidemiological studies show significant associations between PAH exposures and poor human sperm quality and increased levels of bulky DNA adducts [35, 36]. …”

Section: Do Paternal Exposures To Environmental Toxins Promote Transgmentioning

confidence: 99%

A paternal environmental legacy: Evidence for epigenetic inheritance through the male germ line

et al. 2014

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Literature on maternal exposures and the risk of epigenetic changes or diseases in the offspring is growing. Paternal contributions are often not considered. However, some animal and epidemiologic studies on various contaminants, nutrition, and lifestyle-related conditions suggest a paternal influence on the offspring’s future health. The phenotypic outcomes may have been attributed to DNA damage or mutations, but increasing evidence shows that the inheritance of environmentally induced functional changes of the genome, and related disorders, are (also) driven by epigenetic components. In this essay we suggest the existence of epigenetic windows of susceptibility to environmental insults during sperm development. Changes in DNA methylation, histone modification, and non-coding RNAs are viable mechanistic candidates for a non-genetic transfer of paternal environmental information, from maturing germ cell to zygote. Inclusion of paternal factors in future research will ultimately improve the understanding of transgenerational epigenetic plasticity and health-related effects in future generations.

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“…To our knowledge, adverse birth outcomes in relation to coke emissions have not been evaluated in previous literature although coke oven emissions are classified as a known human carcinogen [16] and previous studies have associated occupational exposure to coke oven emissions with increased cancer incidence, decreased lung function, and decreased sperm quality [17]. Previous studies reported that there was no association between emergency department admissions for cardiovascular or respiratory disease and proximity to coke works in England [18], whereas general practice consultations for respiratory disorders was increased in areas closest to coke works in England [19].…”

Section: Introductionmentioning

confidence: 99%

Spatiotemporal association between birth outcomes and coke production and steel making facilities in Alabama, USA: a cross-sectional study

et al. 2014

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BackgroundPrevious research has shown exposure to air pollution increases the risk of adverse birth outcomes, although the effects of residential proximity to significant industrial point sources are less defined. The objective of the current study was to determine whether yearly reported releases from major industrial point sources are associated with adverse birth outcomes.MethodsMaternal residence from geocoded Alabama birth records between 1991 and 2010 were used to calculate distances from coke and steel production industries reporting emissions to the U.S. Environmental Protection Agency. Logistic regression models were built to determine associations between distance or yearly fugitive emissions (volatile organic compounds, polycyclic aromatic compounds, and metals) from reporting facilities and preterm birth or low birth weight, adjusting for covariates including maternal age, race, payment method, education level, year and parity.ResultsA small but significant association between preterm birth and residential proximity (≤5.0 km) to coke and steel production facilities remained after adjustment for covariates (OR 1.05 95% CI: 1.01,1.09). Above average emissions from these facilities of volatile organic compounds during the year of birth were associated with low birth weight (OR 1.17 95% CI: 1.06, 1.29), whereas metals emissions were associated with preterm birth (OR 1.07 95% CI: 1.01, 1.14).ConclusionsThe present investigation suggests fugitive emissions from industrial point sources may increase the risk of adverse birth outcomes in surrounding neighborhoods. Further research teasing apart the relationship between exposure to emissions and area-level deprivation in neighborhoods surrounding industrial facilities and their combined effects on birth outcomes is needed.Electronic supplementary materialThe online version of this article (doi:10.1186/1476-069X-13-85) contains supplementary material, which is available to authorized users.

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Biomonitoring of polycyclic aromatic hydrocarbons from coke oven emissions and reproductive toxicity in nonsmoking workers

Cited by 51 publications

References 54 publications

Association between a biomarker of exposure to polycyclic aromatic hydrocarbons and semen quality

Association between a biomarker of exposure to polycyclic aromatic hydrocarbons and semen quality

A paternal environmental legacy: Evidence for epigenetic inheritance through the male germ line

Spatiotemporal association between birth outcomes and coke production and steel making facilities in Alabama, USA: a cross-sectional study

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