Since the discovery of graphene, 2D materials have been widely applied to field-effect transistors (FETs) due to their great potential in optoelectronics, photodetectors, intelligent sensors, and neuromorphic devices. By integrating 2D transistor with triboelectric nanogenerator (TENG) into tribotronic transistor, the induced triboelectric potential can readily regulate the charge carrier transport characteristics in semiconductor channel. The emerging research field of tribotronics (mainly tribotronic transistors) has gained extensive attentions due to their significant applications on various sensation and human-machine interaction. Here, this review summarizes the recent development of 2D tribotronic transistors. Firstly, the electrical, optoelectronic, and piezoelectric properties of typical 2D materials are introduced. Then, the tribotronic tuning at the micro/nano-scale is raised with the methodologies of thermionic emission, triboelectricity tunneling, and atomic force microscope (AFM) probe scanning, which is of great significance to investigate the underlying mechanism of tribotronic effect. In addition, the macro-scale tribotronic regulation via TENG mechanical displacement are also discussed in detail to explore the applications of 2D tribotronic transistors in intelligent sensors, logic devices, memory devices, and artificial synapses. Finally, the challenges and perspectives for 2D tribotronic transistor are discussed.