BIOnic Liquids: Imidazolium-based Ionic Liquids with Antimicrobial Activity

Postleb, Frank; Stefanik, Danuta; Seifert, Harald; Giernoth, Ralf

doi:10.5560/znb.2013-3150

Cited by 37 publications

(23 citation statements)

References 11 publications

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Section: Modified Amps and Amp Conjugatesmentioning

confidence: 99%

“…In a previous work, we investigated the influence of imidazolium cations on the activity of AMPs [ 72 , 73 ]. Based on observations that imidazolium cations, as part of so-called ionic liquids [ 73 , 129 ], exhibit antimicrobial activity, these compounds were covalently and non-covalently added to AMPs. AMPs used for coupling were sC18 [ 125 ] and the LL-37 peptide, which also belongs to the group of cathelicidins and is a two-amino acid truncated form of FALL-39 [ 13 , 130 ].…”

Section: Modified Amps and Amp Conjugatesmentioning

confidence: 99%

“…Notably, non-covalent mixtures were not as efficient as the covalently-bridged constructs. Furthermore, one short AMP-IL-conjugate, IL-KKA, was identified that also showed promising selectivity towards bacterial membranes compared to eukaryotic ones [ 72 , 73 ].…”

Section: Modified Amps and Amp Conjugatesmentioning

confidence: 99%

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Design and Application of Antimicrobial Peptide Conjugates

Reinhardt

Neundorf

2016

IJMS

129

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Antimicrobial peptides (AMPs) are an interesting class of antibiotics characterized by their unique antibiotic activity and lower propensity for developing resistance compared to common antibiotics. They belong to the class of membrane-active peptides and usually act selectively against bacteria, fungi and protozoans. AMPs, but also peptide conjugates containing AMPs, have come more and more into the focus of research during the last few years. Within this article, recent work on AMP conjugates is reviewed. Different aspects will be highlighted as a combination of AMPs with antibiotics or organometallic compounds aiming to increase antibacterial activity or target selectivity, conjugation with photosensitizers for improving photodynamic therapy (PDT) or the attachment to particles, to name only a few. Owing to the enormous resonance of antimicrobial conjugates in the literature so far, this research topic seems to be very attractive to different scientific fields, like medicine, biology, biochemistry or chemistry.

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Section: Modified Amps and Amp Conjugatesmentioning

confidence: 99%

Section: Modified Amps and Amp Conjugatesmentioning

confidence: 99%

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Design and Application of Antimicrobial Peptide Conjugates

Reinhardt

Neundorf

2016

IJMS

129

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“…[ 15–17 ] By contrast, the imidazolium‐containing ionic liquid (IL) ligands which essentially consist of an aromatic heterocycle containing two nitrogen atoms, with one in the cationic form, are perhaps the most widely studied in the biological field because of their unique physical and chemical properties. [ 18–20 ] Moreover, extensive biochemical and pharmacological studies have confirmed imidazole as effective compounds in treating various strains of microorganisms. [ 21–23 ] Their antibacterial and antifungal effects are attributed to cationic interactions with negatively charged parts of bacterial membranes.…”

Section: Introductionmentioning

confidence: 99%

Biological assays and theoretical density functional theory calculations of Rh(I), Ir(III), and Ru(II) complexes of chiral phosphinite ligand

Rafikova

Binbay

Meri̇ç

et al. 2020

Applied Organom Chemis

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Four metal complexes, IL‐OPPh2‐Ru‐p‐cymene (3), IL‐OPPh2‐Ru‐benzene (4), IL‐OPPh2‐Ir‐Cp* (5), IL‐OPPh2‐Rh‐COD (6), have been evaluated for in vitro antioxidant activity such as 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) radical scavenging and reducing power activity. Maximum scavenging activity (71.43%) was obtained with IL‐OPPh2‐Ru‐p‐cymene, whereas IL‐OPPh2‐Rh‐COD showed the highest reducing power ability. The complexes were also studied for their antimicrobial activity against three Gram‐positive and three Gram‐negative bacteria. In addition, DNA binding of the complexes was evaluated using calf thymus DNA. Both Ru(II) complexes exhibited good DNA‐binding activity while the other complexes did not have any activity. Furthermore, ab initio quantum calculations of four complexes were also carried out using density functional theory to better understand their chemical behaviors.

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“…With these special properties, ILs have been widely used in many applications, such as batteries, 24,25 catalysis, [26][27][28] drug delivery 29,30 and solvents [31][32][33] . A recent patent described a FO process to use ILs as draw solutions, but didn't mention the regeneration methods.…”

Section: Introductionmentioning

confidence: 99%

Using UCST Ionic Liquid as a Draw Solute in Forward Osmosis to Treat High-Salinity Water

Zhong

Feng

Chen

et al. 2015

Environ. Sci. Technol.

115

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Using UCST ionic liquid as a draw solute in forward osmosis to treat high-salinity water Just Accepted "Just Accepted" manuscripts have been peer-reviewed and accepted for publication. They are posted online prior to technical editing, formatting for publication and author proofing. The American Chemical Society provides "Just Accepted" as a free service to the research community to expedite the dissemination of scientific material as soon as possible after acceptance. "Just Accepted" manuscripts appear in full in PDF format accompanied by an HTML abstract. "Just Accepted" manuscripts have been fully peer reviewed, but should not be considered the official version of record. They are accessible to all readers and citable by the Digital Object Identifier (DOI®). "Just Accepted" is an optional service offered to authors. Therefore, the "Just Accepted" Web site may not include all articles that will be published in the journal. After a manuscript is technically edited and formatted, it will be removed from the "Just Accepted" Web site and published as an ASAP article. Note that technical editing may introduce minor changes to the manuscript text and/or graphics which could affect content, and all legal disclaimers and ethical guidelines that apply to the journal pertain. ACS cannot be held responsible for errors or consequences arising from the use of information contained in these "Just Accepted" manuscripts. KAUST Repository 1Using UCST ionic liquid as a draw solute in forward osmosis to treat high-salinity water IL-rich phase: the water-rich phase was the produced water that contained a low IL concentration, and the IL-rich phase could be used directly as the draw solution in the next cycle of the FO process. The thermal stability, thermal-responsive solubility and UV-vis absorption spectra of the IL were also studied in detail.

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BIOnic Liquids: Imidazolium-based Ionic Liquids with Antimicrobial Activity

Cited by 37 publications

References 11 publications

Design and Application of Antimicrobial Peptide Conjugates

Design and Application of Antimicrobial Peptide Conjugates

Biological assays and theoretical density functional theory calculations of Rh(I), Ir(III), and Ru(II) complexes of chiral phosphinite ligand

Using UCST Ionic Liquid as a Draw Solute in Forward Osmosis to Treat High-Salinity Water

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