Bioorganic Chemistry of Ceramide

Abstract

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Molecular species of ceramides from the ascomycete truffle Tuber indicum

“…The ceramides, cleavage products of sphingolipids, including gangliosides and cerebrosides, are involved in various signal transduction pathways (Brodesser et al, 2003). Many extracellular stresses, such as tumor necrosis factors-␣ and human immunodeficiency virus have been shown to activate sphingomyelinases that release ceramides which inhibit cell growth and induce apoptosis (Kolter and Sandhoff, 1999;Van Veldhoven et al, 1992).…”

Inhibitors of dihydroceramide desaturase 1: Therapeutic agents and pharmacological tools to decipher the role of dihydroceramides in cell biology

“…A C12-dihydroceramide analogue with a cyclopropane ring at C-5 and C-6 has been described (1, Figure 5) and shown to inhibit Des1 activity, although to a much lesser extent that GT11, in cultured keratinocytes (Brodesser and Kolter, 2011;Brodesser et al, 2003). On the other hand, two dhCer analogs with an allylic fluoride replacing 3-hydroxyl group have been reported (2, Figure 5) (Jonghe et al, 2000).…”

New Sphingolipids with a Previously Unreported 9‐Methyl‐C20‐sphingosine Moiety from a Marine Algous Endophytic Fungus Aspergillus niger EN‐13

“…They play an important role in recognition of pathogens, signal transduction, cell differentiation, and apoptosis of cancer cells. Many sphingolipids have been found to exhibit antihepatotoxic, antitumor, antifungal, antiviral, neuritogenic, and immunoregulatory activities [1][2][3][4] and have drawn more and more interest from chemical and medicinal researchers. Since the 1990s, marine derived fungi have been recognized as a rich source of novel bioactive metabolites because their environments differ from those of terrestrial fungi [5].…”