Bioorthogonal nanozymes: an emerging strategy for disease therapy

Zhang, Zheao; Fan, Kelong

doi:10.1039/d2nr05920g

Cited by 20 publications

(9 citation statements)

References 87 publications

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“…Incorporating click chemistry reaction sites on the surface of the nanozyme to achieve bioconjugation and construct asymmetric structures provides an elegant means to modulate remaining substrate interactions. [ 296 ] By leveraging these strategies, researchers can continue to refine the performance of Co‐based nanozymes and unlock their full potential in sensing and detection applications. [ 297 ]…”

Section: Discussionmentioning

confidence: 99%

Co‐based Nanozymatic Profiling: Advances Spanning Chemistry, Biomedical, and Environmental Sciences

Li,

Cai,

Jiang

et al. 2023

Advanced Materials

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Nanozymes, next‐generation enzyme‐mimicking nanomaterials, have entered an era of rational design; among them, Co‐based nanozymes have emerged as captivating players over times. Co‐based nanozymes were developed and have garnered significant attention over the past five years. Their extraordinary properties, including regulatable enzymatic activity, stability, and multifunctionality stemming from magnetic properties, photothermal conversion effects, cavitation effects, and relaxation efficiency, have made Co‐based nanozymes a rising star. This review presents the first comprehensive profiling of the Co‐based nanozymes in the chemistry, biology, and environmental sciences. The review begins by scrutinizing the various synthetic methods employed for Co‐based nanozyme fabrication, such as template and sol‐gel methods, highlighting their distinctive merits from a chemical standpoint. Furthermore, we provide a detailed exploration of their wide‐ranging applications in biosensing and biomedical therapeutics, as well as their contributions to environmental monitoring and remediation. Notably, drawing inspiration from state‐of‐the‐art techniques such as omics, a comprehensive analysis of Co‐based nanozymes is undertaken, employing analogous statistical methodologies to provide valuable guidance. To conclude, we present a comprehensive outlook on the challenges and prospects for Co‐based nanozymes, spanning from microscopic physicochemical mechanisms to macroscopic clinical translational applications.This article is protected by copyright. All rights reserved

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Section: Discussionmentioning

confidence: 99%

Co‐based Nanozymatic Profiling: Advances Spanning Chemistry, Biomedical, and Environmental Sciences

Li,

Cai,

Jiang

et al. 2023

Advanced Materials

Self Cite

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“…A variety of nanoparticle scaffolds can be used to encapsulate TMCs, including silica nanoparticles (SiONPs), gold nanoparticles (AuNPs), metal‐organic frameworks (MOFs), polymeric nanoparticles, and resin nanoparticles ( Table 1 ). [ 59 ] Each of these scaffolds provides unique features for the resulting nanozyme. SiONPs are stable under physiological conditions and different pHs, but they possess low biocompatibility.…”

Section: Step 2: Choosing the Nanoscaffoldmentioning

confidence: 99%

Modular Fabrication of Bioorthogonal Nanozymes for Biomedical Applications

et al. 2023

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The incorporation of transition metal catalysts (TMCs) into nanoscaffolds generates nanocatalysts that replicate key aspects of enzymatic behavior. The TMCs can access bioorthogonal chemistry unavailable to living systems. These bioorthogonal nanozymes can be employed as in situ “factories” for generating bioactive molecules where needed. The generation of effective bioorthogonal nanozymes requires co‐engineering of the TMC and the nanometric scaffold. This review presents an overview of recent advances in the field of bioorthogonal nanozymes, focusing on modular design aspects of both nanomaterial and catalyst and how they synergistically work together for in situ uncaging of imaging and therapeutic agents.This article is protected by copyright. All rights reserved

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“…Such nanoparticles can be classified to the group of so-called bioorthogonal nanozymes, nanomaterials with enzyme-like properties. 7,53 The nanomaterial scaffolds not only solubilize the catalysts in water, but also protect them from deactivating components in living cells and minimize overall cytotoxicity. They allow substrate accumulation near the catalyst site by the "concentrator effect", 54 enhancing the reaction rate at low concentrations.…”

Section: Introductionmentioning

confidence: 99%

Amphiphilic polymeric nanoparticles enable homogenous rhodium-catalysed NH insertion reactions in living cells

et al. 2023

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Bioorthogonal nanozymes: an emerging strategy for disease therapy

Abstract: Transition metal catalysts (TMCs), capable of performing bioorthogonal reactions, have been engineered to trigger the formation of bioactive molecules in a controlled manner for biomedical applications. However, the widespread use...

Cited by 20 publications

References 87 publications

Co‐based Nanozymatic Profiling: Advances Spanning Chemistry, Biomedical, and Environmental Sciences

Co‐based Nanozymatic Profiling: Advances Spanning Chemistry, Biomedical, and Environmental Sciences

Modular Fabrication of Bioorthogonal Nanozymes for Biomedical Applications

Amphiphilic polymeric nanoparticles enable homogenous rhodium-catalysed NH insertion reactions in living cells

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