Biopharmaceutical applications of microbial polysaccharides as materials: A Review

Song, Yi-Ge; Li, Shuxin; Gong, Haimei; Yip, Ryan Chak Sang; Chen, Hao

doi:10.1016/j.ijbiomac.2023.124259

Cited by 28 publications

(7 citation statements)

References 354 publications

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“…Additionally, they can be used to develop efficient drug delivery systems (Ahmad et al, 2015;Wang et al 2023a). Microbial polysaccharides include biological actions that include cholesterol-lowering, antimicrobial properties (Song et al 2023). Based on their morphological location, microbial polysaccharides can be sorted into three groups: intracellular, cell wall, and extracellular polysaccharides (Ahmad et al, 2015).…”

Section: Microbial Polysaccharidesmentioning

confidence: 99%

Research progress on the polysaccharide extraction and antibacterial activity

Liang,

Su,

et al. 2024

Ann Microbiol

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Background Over time, the amount of germs resistant to antibacterial medications has been steadily rising because of their prolonged and indiscriminate use. The increase in drug resistance significantly threatens to human health and has become a globally recognized issue of concern. Therefore, identifying new antibacterial drugs is urgently needed. Forward Polysaccharides are natural macromolecular substances that exist in plants, microorganisms, and animals, They have an immense amount of use in the food and medical industries. Polysaccharides can be categorized as plant, animal, or microbial based on the sources of the polysaccharides. Conclusion Polysaccharides are natural compounds with antibacterial properties that exerts antibacterial activity by disrupting bacterial cell walls and cell membranes. They show potential as candidates for the creation and application of novel antibiotics. This article reviews the classification of polysaccharides, their isolation and purification, mechanisms of action, and antibacterial activity. The primary objective of this study is to lay down an empirical groundwork for examining the antibacterial properties of polysaccharides.

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Section: Microbial Polysaccharidesmentioning

confidence: 99%

Research progress on the polysaccharide extraction and antibacterial activity

Liang,

Su,

et al. 2024

Ann Microbiol

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“…EPSs derived from plants and animals are challenging to extract and purify from organic organisms. Moreover, seasonal variations impact the yield and production costs associated with plant- and animal-derived EPS, making large-scale production and utilization difficult [ 21 ]. EPSs produced by bacteria, however, have a short production cycle, which enables high production efficiency throughout the fermentation process.…”

Section: Introductionmentioning

confidence: 99%

“…EPSs produced by bacteria, however, have a short production cycle, which enables high production efficiency throughout the fermentation process. In addition, the easy purification process of microbial EPS addresses issues associated with plant and animal-derived EPS, making them advantageous for industrial application [ 21 - 23 ]. The traditional method of analyzing responses by changing one independent variable at a time is time-consuming and cost-intensive, and cannot be used to determine the interactions between independent variables [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Optimization of Culture Medium for the Production of an Exopolysaccharide (p-CY02) with Cryoprotective Activity by Pseudoalteromonas sp. RosPo-2 from the Antarctic Sea

Kang,

Kim,

Park

et al. 2024

J. Microbiol. Biotechnol.

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When cells are exposed to freezing temperatures, high concentrations of cryoprotective agents (CPA) prevent ice crystal formation, thus enhancing cell survival. However, high concentrations of CPAs can also cause cell toxicity. Exopolysaccharides (EPSs) from polar marine environments exhibit lower toxicity and display effects similar to traditional CPA. In this study, we sought to address these issues by i) selecting strains that produce EPS with novel cryoprotective activity, and ii) optimizing culture conditions for EPS production. Sixty-six bacteria producing mucous substances were isolated from the Ross Sea (Antarctic Ocean) using solid marine agar plates. Among them, Pseudoalteromonas sp. RosPo-2 was ultimately selected based on the rheological properties of the produced EPS (p-CY02). Cryoprotective activity experiments demonstrated that p-CY02 exhibited significantly cryoprotective activity at a concentration of 0.8% (w/v) on mammalian cells (HaCaT). This activity was further improved when combined with various concentrations of dimethyl sulfoxide (DMSO) compared to using DMSO alone. Moreover, the survival rate of HaCaT cells treated with 5% (v/v) DMSO and 0.8% (w/v) p-CY02 was measured at 87.9 ± 2.8% after freezing treatment. This suggests that p-CY02 may be developed as a more effective, less toxic, and novel non-permeating CPA. To enhance the production of EPS with cryoprotective activity, Response Surface Methodology (RSM) was implemented, resulting in a 1.64-fold increase in production of EPS with cryoprotective activity.

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“…Compared with other sources, microbial polysaccharides have advantages with respect to being economical, easy to handle, and having short production cycles [ 12 ]. In addition to these merits, microbial polysaccharides have been applied in the food and biomedical fields because of their physical properties and pharmaceutical-related actions [ 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

New Polyvinyl Alcohol/Succinoglycan-Based Hydrogels for pH-Responsive Drug Delivery

Jeong

Kim

et al. 2023

Polymers

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We fabricated new hydrogels using polyvinyl alcohol (PVA) and succinoglycan (SG) directly isolated and obtained from Sinorhizobium meliloti Rm 1021 via the freeze–thaw method. Both the composition of the hydrogels and the freeze–thaw cycles were optimized to maximize the swelling ratio for the preparation of the PVA/SG hydrogels. During the optimization process, the morphology and conformational change in the hydrogel were analyzed by scanning electron microscopy, rheological measurements, and compressive tests. An optimized hydrogel with a maximum swelling ratio of 17.28 g/g was obtained when the composition of PVA to SG was 50:50 (PVA/SG 50/50) and the total number of freeze–thaw cycles was five. The PVA/SG 50/50 hydrogel had the largest pore with 51.24% porosity and the highest cross-over point (28.17%) between the storage modulus (G′) and the loss modulus (G″). The PVA/SG 50/50 hydrogel showed improved thermal stability owing to its interaction with thermally stable SG chains. The improvement in the thermal stability was confirmed by thermogravimetric analysis and differential scanning calorimetry. In addition, the PVA/SG 50/50 hydrogel showed differential drug release according to the corresponding pH under acidic conditions of pH 1.2 and slightly basic conditions of pH 7.4. Furthermore, the cell viability test on the HEK-293 cell line for that hydrogel demonstrated that the PVA/SG 50/50 hydrogel was non-toxic and biocompatible. Therefore, this hydrogel could be a potential scaffold capable of pH-responsive drug delivery for chronic wound dressing applications.

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Biopharmaceutical applications of microbial polysaccharides as materials: A Review

Cited by 28 publications

References 354 publications

Research progress on the polysaccharide extraction and antibacterial activity

Research progress on the polysaccharide extraction and antibacterial activity

Optimization of Culture Medium for the Production of an Exopolysaccharide (p-CY02) with Cryoprotective Activity by Pseudoalteromonas sp. RosPo-2 from the Antarctic Sea

New Polyvinyl Alcohol/Succinoglycan-Based Hydrogels for pH-Responsive Drug Delivery

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