Biopharmaceutical applications of nanogold

Alanazi, Fars K.; Radwan, A E; Alsarra, Ibrahim A.

doi:10.1016/j.jsps.2010.07.002

Cited by 143 publications

(83 citation statements)

References 111 publications

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“…Particles which have two or more dimensions in size range as 1-100 nm or one billionth part of a meter are defined as one nanoparticles (NPs) [1]. NPs have a unique chemical and physical properties as compared to their solid bulk materials because of their high surface area and electronic properties.…”

Section: Introductionmentioning

confidence: 99%

Comparative Analysis of Metal Nanoparticles Synthesized From Hibiscus Rosa Sinesis and Their Antibacterial Activity Estimation Against Nine Pathogenic Bacteria

Tyagi

Kumar

Tyagi

2017

Asian J Pharm Clin Res

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Objective: This study demonstrates a simple, cost-effective protocol for biosynthesis of stable silver nanoparticles (AgNPs) and gold nanoparticles (AuNPs) from Hibiscus rosa-sinesis and their comparison by applying antibacterial activities against nine pathogenic bacterial species.Methods: AgNPs and AuNPs were biosynthesized from H. rosa-sinesis. The antibacterial activities of biosynthesized AgNPs (bio-AgNPs) and biosynthesized AuNPs (bio-AuNPs) were evaluated against 9 pathogenic bacterial species Pseudomonas aeruginosa, Bacillus subtilis, Micrococcus luteus, Staphylococcus aureus, Staphylococcus epidermidis, Enterobacter aerogenes, Escherichia coli, Streptococcus pneumoniae, Aeromonas hydrophila by the agar disc diffusion method.Results: Biological synthesized AgNP/AuNPs were characterized by an ultraviolet-visible (UV-Vis) spectrophotometer, Fourier transform infrared spectroscopy (FTIR), and transmission electron microscopy (TEM). The existence of silver and gold ions in the extracts was conformed (primary confirmation) through UV-Vis and the maximum plasmon peak was observed at 402 and 530 nm of bio-AgNPs and bio-AuNPs, respectively. Bio-AgNPs were obtained in 13.01-28.14 nm size range, whereas bio-AuNPs were in 6.32-18.19 nm size range after analysis of TEM images. The results of FTIR spectra indicate that the bio-AuNPs were bound to amine groups and bio-AgNPs to carboxylate ion groups. The antibacterial activities of AgNP/AuNP, the zone of inhibition significantly increased with the increases of concentrations of bio-AgNPs in all pathogenic bacterial species except in the case of S. epidermidis at 50%, Streptococcus aerogenes and A. hydrophila at 70%, whereas in the case of bio-AuNPs antibacterial activities were displayed only against B. subtilis at 20% and 100% concentration. Conclusion:This study suggests that AgNPs exhibits outstanding antibacterial activity against pathogenic bacteria as compared to AuNPs synthesized from H. rosa-sinensis leaf extract and insights to their potential applicability as an alternative antibacterial agent in microbial and human health system to reduce the resistance ability of pathogenic bacteria.

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Section: Introductionmentioning

confidence: 99%

Comparative Analysis of Metal Nanoparticles Synthesized From Hibiscus Rosa Sinesis and Their Antibacterial Activity Estimation Against Nine Pathogenic Bacteria

Tyagi

Kumar

Tyagi

2017

Asian J Pharm Clin Res

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“…Another important aspect of GNPs is their ability to disperse uniformly and reach the targeted site along with the blood flow [23]. They have also found to be biocompatible [24] with their overall cytotoxicity within acceptable limits [25].…”

Section: Applications Of Gold Nanoparticles In the Field Of Medicinementioning

confidence: 99%

Review of Applications and Environmental Fate of Gold Nanoparticles

Palaniappan¹

2018

International Conference of Recent Trends in Environmental Science and Engineering

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-The unique properties of nanomaterials do enable them to contribute significantly to environmental protection; however at the same time, they also have a significant negative impact on the environment as well as on living organisms. Among the existing nanomaterials, gold nanoparticle (GNP) is quickly gaining grounds due to its wide ranging uses in the field of medicine, especially radiation therapy and targeted drug delivery. Apparently, the increased production, application and disposal of GNPs have led to an increased release of nanogold into the environment and there are very few studies that bring out the implications of such release. This study aims to review various applications of GNPs and their fate in the environment.

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“…Gold nanoparticles exhibit different shapes such as spherical, sub-octahedral, octahedral, decahedral, icosahedral multiple twined, multiple twined, irregular shape, tetrahedral, nanotriangles, nanoprisms, hexagonal platelets, and nanorods, which are shown in Figure 2. Among the various shapes triangular-shaped nanoparticles show attractive optical properties compared with the spherical-shaped nanoparticles [30,58,[63][64][65][66][67][68][69][70][71][72]. …”

Section: Metal Nanoparticle (Gold Nanoparticle)mentioning

confidence: 99%