Nanoscale Fabrication, Optimization, Scale-Up and Biological Aspects of Pharmaceutical Nanotechnology 2018
DOI: 10.1016/b978-0-12-813629-4.00006-1
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Biopharmaceutics and pharmacokinetics of multifunctional nanoparticles

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Cited by 2 publications
(3 citation statements)
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“…On the other hand, intact amoxicillin nps may be internalized into the intestinal epithelium cells by passing the P‐gp efflux pump and then transported to the systemic circulation via the portal vein. It is informed that nanoparticles in the size range of 10–1,000 nm have the ability to pass through the intestinal mucosa by endocytosis mechanism (Pridgen, Alexis, & Farokhzad, ; Yadav, Dibi, & Mohammed, ).…”
Section: Discussionmentioning
confidence: 99%
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“…On the other hand, intact amoxicillin nps may be internalized into the intestinal epithelium cells by passing the P‐gp efflux pump and then transported to the systemic circulation via the portal vein. It is informed that nanoparticles in the size range of 10–1,000 nm have the ability to pass through the intestinal mucosa by endocytosis mechanism (Pridgen, Alexis, & Farokhzad, ; Yadav, Dibi, & Mohammed, ).…”
Section: Discussionmentioning
confidence: 99%
“…Nanoparticles can be potentially transported across the intestinal epithelium via transcellular (includes passive diffusion, active carrier, and endocytosis) or paracellular (mainly passive) pathways (Berardi & Bisharat, ; Shekhawat & Pokharkar, ). Particle size is one of the most important parameters that influence the transport of particles, and nanoparticles in the size range of 10–1,000 nm have the ability to pass through the intestinal mucosa by endocytosis mechanism (Yadav et al., ). Amoxicillin nps have negatively charged with a mean size of 500 nm, suitable for uptake within the gastrointestinal tract (Sarmento, Ribeiro, Veiga, Ferreira, & Neufeld, ).…”
Section: Discussionmentioning
confidence: 99%
“…Essas estruturas podem ser formadas por diversos tipos de materiais poliméricos. Partículas com origem de polímeros sintéticos: podem ser sintetizadas a partir de polímeros biodegradáveis ou não biodegradáveis, entre as mais comuns estão: os dendrímeros formadas por um núcleo polimérico altamente ramificado com um diâmetro menor a 15 nm, e que tem sido usados para melhorar a solubilidade de fármacos, porém há estudos que mostram altos níveis de toxicidade e hemólise[30]. Os micro ou nano géis são estruturas compostas por ligações tridimensionais entre a rede de cadeias poliméricas, possuem alta estabilidade e tem uma penetração transdérmica efetiva.…”
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