Biophotonic effect of diode laser irradiance on tensile strength of diabetic rats

Abstract

Low-energy laser irradiance at certain wavelengths is able to stimulate the tissue bio-reaction and enhance the healing process. Collagen deposition is one of the important aspects in healing process because it can increase the strength of the skin. This study was designed to examine the biophotonic effect of irradiance on collagen production of diabetic wound in rat model. The tensile strength of skin was employed as a parameter to describe the wound. Diabetic rat models were induced by streptozotocin via intravenous injection. Skin-breaking strength was measured using an Instron tensile test machine. The experimental animals were treated with 808-nm diode laser at two different powers-0.1 and 0.5 W/cm(2)-and 30, 60, and 120 s for each session. The tensile strength was optimized after treated with high-power diode laser. The photostimulation effect was revealed by accelerated healing process and enhanced tensile strength of wound. Laser photostimulation on tensile strength in diabetic wound suggests that such therapy facilitates collagen production in diabetic wound healing.

Efficacy of Biophysical Energies on Healing of Diabetic Skin Wounds in Cell Studies and Animal Experimental Models: A Systematic Review

“…The trials were conducted between 1984 and 2018. Overall, there were five trials on PEMF [19,20,21,22,23], three trials on US [24,25,26], four trials on ECSW [27,28,29,30], four trials on ES [31,32,33,34] and sixty-six trials on LLL [35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,…”

“…The photo energies reported for treating diabetic wounds encompass low-level laser energy [35,37,38,40,42,43,44,47,48,49,50,51,52,53,54,55,59,60,61,62,63,64,65,66,68,69,71,72,73,74,75,76,77,78,80,81,82,83,84,85,86,87,88,89,90,92,93,97,99,100], near-infrared [36], polychromatic light emitting diodes [39,41,45,67,70] and monochromatic infrared energy [79]. Some studies also compared different types of photo energy [46,56,57,58] (Table 5 and Table 6).…”

The Need for Increased Attention to Low‐Level Laser Therapy as Treatment for Wounds and Ulcers

“…The photostimulation effect was shown by the accelerated healing process and enhanced tensile strength of the wound. Lau et al concluded that LLLT facilitated collagen production in diabetic wound healing [24]. Sharifian et al assessed the influence of pulsed wave (PW) LLLT on healing of the diabetic wound in diabetic (STZ-D) rats.…”

Influence of gold nanoparticles on wound healing treatment in rat model: Photobiomodulation therapy

“…Light therapy known as photobiomodulation therapy (PBMT) uses low level light to stimulate cellular function and activate cellular respiratory chain to increase the metabolism process . A large number of positive results of PBMT on wound healing have been reported in vivo or in vitro studies . PBMT has capability to increase cellular migration, reduce cellular apoptosis, stimulate angiogenesis, restore microcirculation, and enhance quality of wound .…”