Biophysical and Lipidomic Biomarkers of Cardiac Remodeling Post-Myocardial Infarction in Humans

Samouillan, Valérie; Samper, Ignacio Miguel Martinez de Lejarza; Amaro, Aleyda Benitez; Viladés, David; Dandurand, Jany; Casas, Josefina; Jorge, Esther; Gonzalo-Calvo, David de; Gallardo, Alberto; Lerma, Enrique; Guerra, José M.; Carreras, Francesc; Leta, Rubén; Cortes, Vicenta Llorente

doi:10.3390/biom10111471

Cited by 19 publications

(17 citation statements)

References 55 publications

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“…The blue cluster (cluster #1) was dominated by lipidomics, proteomics, genome-wide association, identification, and mass spectrometry, which were mainly related to the description of the research methods. Lipidomics has been used for research on CAD clinical endpoint events (33)(34)(35), left ventricular remodelling (36)(37)(38), and so on. The combined use of proteomics and metabolomics provides a way to better understand the mechanisms of CAD (39).…”

Section: Keyword Co-occurrencementioning

confidence: 99%

“…"risk, " "biomarkers, " "insulin resistance, " "atherosclerosis, " "obesity, " "inflammation, " "Oxidative stress, " "mass spectrometry, " "gut microbiota, " and so on are the main keywords of the current study (Table 6). Among them, we can see the research hotspots in recent years: (i) Research on aetiology and pathogenesis in this field, such as insulin resistance (33,73), atherosclerosis (36), inflammation (40), dysfunction (38); the studies on these factors have been described in the keyword co-occurrence section. (ii) Microbiota and metabolites.…”

Section: Hotspots and Frontiersmentioning

confidence: 99%

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Bibliometric and Visual Analysis on Metabolomics in Coronary Artery Disease Research

Wang

Liu

et al. 2022

Front. Cardiovasc. Med.

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BackgroundMetabolomics has immense research value in coronary artery disease and has drawn increasing attention over the past decades. Many articles have been published in this field, which may challenge researchers aiming to investigate all the available information. However, bibliometrics can provide deep insights into this research field.ObjectiveWe aimed to qualitatively and quantitatively study metabolomics and coronary artery disease research, visually analyse the development status, trends, research hotspots, and frontiers of this field, and provide a reference for research on coronary artery disease.MethodsArticles were acquired from the Web of Science Core Collection. VOSviewer and CiteSpace software were used to analyse publication growth, country/region, institution, journal distribution, author, reference, and keywords, and detected the keywords with strong citation burstness to identify emerging topics.ResultsA total of 1121 references were obtained, and the annual number of publications increased over the past 16 years. Metabolomics research has shown a gradual upward trend in coronary artery disease. The United States of America and China ranked at the top in terms of percentage of articles. The institution with the highest number of research publications in this field was Harvard University, followed by the University of California System and Brigham Women’s Hospital. The most frequently cited authors included Hazen SL, Tang WH, and Wang ZN. Ala-Korpela M was the most productive author, followed by Clish CB and Adamski J. The journal with the most publications in this field was Scientific Reports, followed by PLoS One and the Journal of Proteome Research. The keywords used at a high frequency were “risk,” “biomarkers,” “insulin resistance,” and “atherosclerosis.” Burst detection analysis of top keywords showed that “microbiota,” “tryptophan,” and “diabetes” are the current research frontiers in this field.ConclusionThis study provides useful information for acquiring knowledge on metabolomics and coronary artery diseases. Metabolomics research has shown a gradual upward trend in coronary artery disease studies over the past 16 years. Research on tryptophan metabolism regulated by intestinal flora will become an emerging academic trend in this field, which can offer guidance for more extensive and in-depth studies in the future.

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Section: Keyword Co-occurrencementioning

confidence: 99%

Section: Hotspots and Frontiersmentioning

confidence: 99%

Bibliometric and Visual Analysis on Metabolomics in Coronary Artery Disease Research

Wang

Liu

et al. 2022

Front. Cardiovasc. Med.

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“…Levels of unsaturated PC such as PC 34:2, 36:2, and 38:4 and PUFA in general were consistently higher in the RV versus LV of both WT and both Rbp1 –/– mice and also in LV and RV of Rbp1 –/– versus corresponding ventricle of WT mice. The right‐left differential composition was also observed in both healthy and injured human hearts 73 …”

Section: Discussionmentioning

confidence: 77%

“…The right-left differential composition was also observed in both healthy and injured human hearts. 73…”

Section: Carnitine and Lipid Biosynthetic Pathwaymentioning

confidence: 99%

Role of cellular retinol‐binding protein, type 1 and retinoid homeostasis in the adult mouse heart: A multi‐omic approach

et al. 2022

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The main active metabolite of Vitamin A, all‐trans retinoic acid (RA), is required for proper cellular function and tissue organization. Heart development has a well‐defined requirement for RA, but there is limited research on the role of RA in the adult heart. Homeostasis of RA includes regulation of membrane receptors, chaperones, enzymes, and nuclear receptors. Cellular retinol‐binding protein, type 1 (CRBP1), encoded by retinol‐binding protein, type 1 (Rbp1), regulates RA homeostasis by delivering vitamin A to enzymes for RA synthesis and protecting it from non‐specific oxidation. In this work, a multi‐omics approach was used to characterize the effect of CRBP1 loss using the Rbp1−/− mouse. Retinoid homeostasis was disrupted in Rbp1−/− mouse heart tissue, as seen by a 33% and 24% decrease in RA levels in the left and right ventricles, respectively, compared to wild‐type mice (WT). To further inform on the effect of disrupted RA homeostasis, we conducted high‐throughput targeted metabolomics. A total of 222 metabolite and metabolite combinations were analyzed, with 33 having differential abundance between Rbp1−/− and WT hearts. Additionally, we performed global proteome profiling to further characterize the impact of CRBP1 loss in adult mouse hearts. More than 2606 unique proteins were identified, with 340 proteins having differential expression between Rbp1−/− and WT hearts. Pathway analysis performed on metabolomic and proteomic data revealed pathways related to cellular metabolism and cardiac metabolism were the most disrupted in Rbp1−/− mice. Together, these studies characterize the effect of CRBP1 loss and reduced RA in the adult heart.

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“…The wide use of pharmacotherapy and revascularization has been associated with a rise of survival rate in patients with STEMI at the early stage of STEMI ( 7 , 8 ). Few studies focused on biochemical parameters to predict the prognosis of myocardial remodeling at the late stage ( 9 ), specifically in patients with STEMI 3–6 months after survival from the onset of the disease ( 10 , 11 ). In light of these findings, there is a need to identify biophysical parameters that reflect the pathological changes of STEMI for better prognosis ( 12 ).…”

Section: Introductionmentioning

confidence: 99%

Plasma Exosome miRNAs Profile in Patients With ST-Segment Elevation Myocardial Infarction

Guan

Zeng

Zhang

et al. 2022

Front. Cardiovasc. Med.

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BackgroundCirculating microRNAs (miRNAs) have been found to have different expressions in different phases of acute myocardial infarction. The profiles of plasma exosome miRNAs in patients with ST-segment elevation myocardial infarction (STEMI) at 3–6 months postinfarction are unknown.ObjectiveThe aim of this study was to assess the profiles of plasma exosome miRNAs in patients with STEMI in comparison with healthy volunteers and to select specific exosome miRNAs related to pathophysiological changes post-STEMI.MethodsPlasma and echocardiography parameters were collected from 30 patients 3–6 months after STEMI and 30 healthy volunteers. Plasma exosome miRNAs were assessed by using high-throughput sequence (Illumina HiSeq 2500) and profile of the plasma exosome miRNAs was established in 10 patients and 6 healthy volunteers. The specific exosome miRNAs related to heart diseases were selected according to the TargetScan database. The specificity of the selected exosome miRNAs was evaluated in additional 20 post-STEMI patients and 24 healthy volunteers by using quantitative PCR (qPCR). Left ventricular remodeling (LVR) was defined using the European Association of Cardiovascular Imaging criteria according to echocardiography examination. Correlations between expression of the specific miRNAs and echocardiography parameters of LVR were assessed using the Spearman correlation analysis.ResultsTwenty eight upregulated miRNAs and 49 downregulated miRNAs were found in patients 3–6 months after STEMI (p < 0.01) in comparison with the healthy volunteers. The two least expressed and heart-related exosome miRNAs were hsa-miR-181a-3p (0.64-fold, p < 0.01) and hsa-miR-874-3p (0.50-fold, p < 0.01), which were further confirmed by using qPCR and demonstrated significant specificity in another 20 patients with post-STEMI comparing to 24 healthy volunteers [area under the curve (AUC) = 0.68, p < 0.05; AUC = 0.74, p < 0.05]. The expression of hsa-miR-181a-3p was downregulated in patients with LV adverse remodeling in comparison with patients without LV adverse remodeling and healthy volunteers.ConclusionCirculating exosome miR-874-3p and miR-181a-3p were downregulated in patients with STEMI postinfarction. Exosome hsa-miR-181a-3p might play a potential role in the development of LVR in patients with post-STEMI.

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Biophysical and Lipidomic Biomarkers of Cardiac Remodeling Post-Myocardial Infarction in Humans

Cited by 19 publications

References 55 publications

Bibliometric and Visual Analysis on Metabolomics in Coronary Artery Disease Research

Bibliometric and Visual Analysis on Metabolomics in Coronary Artery Disease Research

Role of cellular retinol‐binding protein, type 1 and retinoid homeostasis in the adult mouse heart: A multi‐omic approach

Plasma Exosome miRNAs Profile in Patients With ST-Segment Elevation Myocardial Infarction

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